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1.
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14 p, 1.9 MB |
Immunoescape of HIV-1 in Env-EL9 CD8 + T cell response restricted by HLA-B*14:02 in a Non progressor who lost twenty-seven years of HIV-1 control
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Moyano, Ana (Max Von Pettenkofer Institute and Gene Center) ;
Blanch-Lombarte, Oscar (Universitat Autònoma de Barcelona) ;
Tarancon-Diez, Laura (Hospital General Universitario Gregorio Marañón) ;
Pedreño-López, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arenas, Miguel (Instituto de Investigación Sanitaria Galicia Sur) ;
Alvaro, Tamara (Centro Nacional de Microbiología (Espanya)) ;
Casado, Concepcion (Centro Nacional de Microbiología (Espanya)) ;
Olivares, Isabel (Centro Nacional de Microbiología (Espanya)) ;
Vera, Mar (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Rodriguez, Carmen (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Del Romero, Jorge (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
López-Galíndez, Cecilio (Centro Nacional de Microbiología (Espanya)) ;
Ruiz-Mateos, Ezequiel (Instituto de Biomedicina de Sevilla) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pernas, María (Centro Nacional de Microbiología (Espanya))
Long-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease progression for prolonged periods. However, the LTNPs status is temporary, as viral load increases followed by decreases in CD4 + T-cell counts. [...]
2022 -  10.1186/s12977-022-00591-7
Retrovirology, Vol. 19 (march 2022)
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2.
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15 p, 4.1 MB |
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART
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Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ;
Pou, Christian (Karolinska Institutet (Estocolm, Suècia). Department of Cell and Molecular Biology) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ;
Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ;
Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)
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3.
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16 p, 1.9 MB |
The infectious synapse formed between mature dendritic cells and CD4 + T cells is independent of the presence of the HIV-1 envelope glycoprotein
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Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puigdomènech, Isabel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Since cell-mediated infection of human immunodeficiency virus type 1 (HIV-1) is more efficient than cell-free infection, cell-to-cell propagation plays a crucial role in the pathogenesis of HIV-1 infection. [...]
2013 - 10.1186/1742-4690-10-42
Retrovirology, Vol. 10 (april 2013) , p. 42
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4.
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11 p, 548.7 KB |
The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype
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Cunyat, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Svicher, Valentina (Department of Experimental Medicine. University of "Tor Vergata," Rome, Italy) ;
Pérez-Álvarez, Núria (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Curriu Martí, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Perno, Carlo Federico (Department of Experimental Medicine. University of "Tor Vergata," Rome, Italy) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Resistance to the fusion inhibitor enfuvirtide (ENF) is achieved by changes in the gp41 subunit of the HIV envelope glycoprotein (Env). Specific ENF-associated mutational pathways correlate with immunological recovery, even after virological failure, suggesting that the acquisition of ENF resistance alters gp41 pathogenicity. [...]
2012 - 10.1186/1742-4690-9-15
Retrovirology, Vol. 9 (february 2012) , p. 15
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5.
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5 p, 846.7 KB |
Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection
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Sironi, Manuela (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Biasin, Mara (University of Milan (Itàlia)) ;
Pontremoli, Chiara (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Cagliani, Rachele (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Saulle, Irma (University of Milan (Itàlia)) ;
Trabattoni, Daria (University of Milan (Itàlia)) ;
Vichi, Francesca (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Lo Caputo, Sergio (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Mazzotta, Francesco (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Aguilar-Jimenez, Wbeimar (Universidad de Antioquia) ;
Rugeles, María Teresa (Universidad de Antioquia) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Asociación Civil Impacta Salud y Educación (Lima, Perú)) ;
Brander, Christian (Universitat de Vic) ;
Clerici, Mario (Foundation ONLUS (Milà, Itàlia)) ;
Universitat Autònoma de Barcelona
Abstract. BACKGROUND: The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modulating HIV susceptibility. [...]
2015 - 10.1186/s12977-015-0206-0
Retrovirology, Vol. 12 Núm. 80 (september 2015)
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15 p, 3.1 MB |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erikson, Elina (University of Frankfurt (Alemanya)) ;
Fernandez Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rausell, Antonio (University of Lausanne (Suïssa)) ;
Ciuffi, Angela (University of Lausanne (Suïssa)) ;
Keppler, Oliver T. (University of Frankfurt (Alemanya)) ;
Telenti, Amalio (University of Lausanne (Suïssa)) ;
Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)
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13 p, 426.6 KB |
HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4
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Puigdomènech Iñiguez, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Massanella Luna, Marta, 1983- (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz Hernández, Raúl (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Curriu Martí, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bofill Soliguer, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Juan, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Julià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Cell-to-cell HIV transmission requires cellular contacts that may be in part mediated by the integrin leukocyte function antigen (LFA)-1 and its ligands intercellular adhesion molecule (ICAM)-1, -2 and -3. [...]
2008 - 10.1186/1742-4690-5-32
Retrovirology, Vol. 5, Núm. 32 (March 2008), p. 1-13
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6 p, 819.3 KB |
On the steps of cell-to-cell HIV transmission between CD4 T cells
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Puigdomènech Iñiguez, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Massanella Luna, Marta, 1983- (Institut Germans Trias i Pujol) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol) ;
Blanco, Julià (Institut Germans Trias i Pujol)
Although cell-to-cell HIV transmission was defined in early 90's, in the last five years, several groups have underscored the relevance of this mode of HIV spread between productively infected and uninfected CD4 T cells by defining the term virological synapse (VS). [...]
2009 - 10.1186/1742-4690-6-89
Retrovirology, Vol. 6, N. 89 (October 2009) , p. 1-6
5 documentos
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17 p, 1.3 MB |
Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy
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Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ;
Garriga, César (Centro Nacional de Epidemiología (Espanya)) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Anta, Lourdes (Hospital Carlos III (Madrid)) ;
Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ;
Pérez Elías, M. Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Mendoza, Carmen de (Hospital Carlos III (Madrid)) ;
Martínez, Miguel A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Menéndez-Arias, Luis (Centro de Biología Molecular Severo Ochoa) ;
Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - 10.1186/1742-4690-9-68
Retrovirology, Vol. 9, N. 68 (13 August 2012) , p. 1-17
2 documentos
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10.
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12 p, 786.4 KB |
Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture
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Martrus, Gloria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Andrés, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez, Miguel Ángel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Background: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication capacity, evolvability and pathogenesis. [...]
2013 - 10.1186/1742-4690-10-78
Retrovirology, Vol. 10, N. 78 (25 July 2013) , p. 1-12
6 documentos
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