UAB Digital Repository of Documents 96 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
1.
17 p, 1.6 MB Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3 / Abrie, J. Albert (Stellenbosch University. Department of Biochemistry) ; Molero Merinero, Cristina (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Strauss, Erick (Stellenbosch University. Department of Biochemistry) ; Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme of Hemiascomycetous yeast. [...]
2015 - 10.1038/srep15774
Scientific Reports, Vol. 5 (October 2015) , art. 15774  
2.
12 p, 1.3 MB Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells / Patiño Padial, Tania (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Soriano Martín, Jorge (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Barrios, L. (Leonardo) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Nogués, C. (Carme) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
The use of micro- and nanodevices as multifunctional systems for biomedical applications has experienced an exponential growth during the past decades. Although a large number of studies have focused on the design and fabrication of new micro- and nanosystems capable of developing multiple functions, a deeper understanding of their interaction with cells is required. [...]
2015 - 10.1038/srep11371
Scientific Reports, Vol. 5 (June 2015) , art. 11371  
3.
15 p, 620.2 KB Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency / Córdoba, Sarai (Centre de Recerca en Agrigenòmica) ; Balcells Ortega, Ingrid (Centre de Recerca en Agrigenòmica) ; Castelló, Anna (Centre de Recerca en Agrigenòmica) ; Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria) ; Noguera Jiménez, José Luis (Institut de Recerca i Tecnologia Agroalimentàries) ; Timoneda i Heredia, Oriol (Centre de Recerca en Agrigenòmica) ; Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ; Universitat Autònoma de Barcelona. Departament de Genètica Animal
2015 0) and low (L, EBV 0) prolificacy phenotypes. For each sample, mRNA and small RNA libraries were RNA-sequenced, identifying 141 genes and 10 miRNAs differentially expressed between H and L groups. We selected four miRNAs based on their role in reproduction, and five genes displaying the highest differences and a positive mapping into known reproductive QTLs for RT-qPCR validation on the whole extreme population. Significant differences were validated for genes: PTGS2 (p = 0.03; H/L ratio = 3.50), PTHLH (p = 0.03; H/L ratio = 3.69), MMP8 (p = 0.01; H/L ratio = 4.41) and SCNN1G (p = 0.04; H/L ratio = 3.42). Although selected miRNAs showed similar expression levels between H and L groups, significant correlation was found between the expression level of ssc-miR-133a (p 0.01) and sscmiR-92a (p 0.01) and validated genes. These results provide a better understanding of the genetic architecture of prolificacy-related traits and embryo implantation failure in pigs. - 10.1038/srep14416
Scientific Reports, Vol. 5 (October 2015) , art. 14416  
4.
7 p, 508.5 KB Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk / Figlioli, Gisella (University of Pisa. Department of Biology) ; Chen, Bowang (German Cancer Research Center (DKFZ). Molecular Genetic Epidemiology (Germany)) ; Elisei, Rossella (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ; Romei, Cristina (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ; Campo, Chiara (University of Pisa. Department of Biology (Italy)) ; Cipollini, Monica (University of Pisa. Department of Biology (Italy)) ; Cristaudo, Alfonso (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ; Bambi, Franco (Blood Centre, Azienda Ospedaliero Universitaria A. Meyer (Italy)) ; Paolicchi, Elisa (University of Pisa. Department of Biology (Italy)) ; Hoffmann, Per (University of Basel. Department of Biomedicine (Switzerland)) ; Herms, Stefan (University of Basel. Department of Biomedicine (Switzerland)) ; Kalemba, Michał (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ; Kula, Dorota (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ; Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Velázquez Henar, María Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Jarząb, Barbara (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ; Landi, Stefano (University of Pisa. Department of Biology (Italy)) ; Hemminki, Kari (Lund University. Center for Primary Health Care Research, Clinical Research Center (Sweden)) ; Gemignani, Federica (University of Pisa. Department of Biology (Italy)) ; Försti, Asta (Lund University. Center for Primary Health Care Research, Clinical Research Center (Sweden))
A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22. [...]
2015 - 10.1038/srep08922
Scientific Reports, Vol. 5 (March 2015) , art. 8922  
5.
7 p, 990.3 KB Rapid genome resequencing of an atoxigenic strain of Aspergillus carbonarius / Cabañes Sáenz, Francisco Javier (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Sanseverino, Walter (Sequentia Biotech SL) ; Castellà Gómez, Gemma (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Bragulat Arara, Mª Rosa (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Cigliano, Riccardo Aiese (Sequentia Biotech SL) ; Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica)
In microorganisms, Ion Torrent sequencing technology has been proved to be useful in whole-genome sequencing of bacterial genomes (5 Mbp). In our study, for the first time we used this technology to perform a resequencing approach in a whole fungal genome (36 Mbp), a non-ochratoxin A producing strain of Aspergillus carbonarius. [...]
2015 - 10.1038/srep09086
Scientific Reports, Vol. 5 (2015) , art. 9086  
6.
5 p, 681.8 KB A Magnetic Wormhole / Prat Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Física) ; Navau Ros, Carles (Universitat Autònoma de Barcelona. Departament de Física) ; Sánchez Moreno, Álvaro (Universitat Autònoma de Barcelona. Departament de Física)
Wormholes are fascinating cosmological objects that can connect two distant regions of the universe. Because of their intriguing nature, constructing a wormhole in a lab seems a formidable task. A theoretical proposal by Greenleaf et al. [...]
2015 - 10.1038/srep12488
Scientific Reports, Vol. 5 (August 2015) , art. 12488  
7.
7 p, 899.7 KB Common features in the unfolding and misfolding of PDZ domains and beyond : the modulatory effect of domain swapping and extra-elements / Murciano Calles, Javier (Universidad de Granada. Departamento de Química Física) ; Güell Bosch, Jofre (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Martínez, José C. (Universidad de Granada. Departamento de Química Física)
PDZ domains are protein-protein interaction modules sharing the same structural arrangement. To discern whether they display common features in their unfolding/misfolding behaviour we have analyzed in this work the unfolding thermodynamics, together with the misfolding kinetics, of the PDZ fold using three archetypical examples: the second and third PDZ domains of the PSD95 protein and the Erbin PDZ domain. [...]
2016 - 10.1038/srep19242
Scientific Reports, Vol. 6 (January 2016) , art. 19242  
8.
8 p, 597.8 KB Relaxation dynamics of glasses along a wide stability and temperature range / Rodríguez Tinoco, Cristian (Universitat Autònoma de Barcelona. Departament de Física) ; Ràfols Ribé, Joan (Universitat Autònoma de Barcelona. Departament de Física) ; González Silveira, Marta (Universitat Autònoma de Barcelona. Departament de Física) ; Rodríguez Viejo, Javier (Universitat Autònoma de Barcelona. Departament de Física)
While lots of measurements describe the relaxation dynamics of the liquid state, experimental data of the glass dynamics at high temperatures are much scarcer. We use ultrafast scanning calorimetry to expand the timescales of the glass to much shorter values than previously achieved. [...]
2016 - 10.1038/srep35607
Scientific Reports, Vol. 6 (October 2016) , art. 35607  
9.
11 p, 1.0 MB ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer / Cedó, Lidia (Institut d'Investigació Biomèdica Sant Pau) ; García León, Annabel (Institut d'Investigacions Biomèdiques Sant Pau) ; Baila Rueda, Lucía (Hospital Universitario Miguel Servet) ; Santos, David (Institut d'Investigacions Biomèdiques Sant Pau) ; Grijalva, Victor (University of California. Department of Medicine) ; Martínez Cignoni, Melanie Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Carbó, José María (Universitat de Barcelona) ; Metso, Jari (Minerva Foundation Institute for Medical Research) ; López Vilaró, Laura (Institut d'Investigacions Biomèdiques Sant Pau) ; Zorzano Olarte, Antonio (Institute for Research in Biomedicine) ; Valledor, Annabel F. (Universitat de Barcelona) ; Cenarro, Ana (Hospital Universitario Miguel Servet) ; Jauhiainen, Matti (Minerva Foundation Institute for Medical Research) ; Lerma Puertas, Enrique (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Fogelman, Alan M. (University of California. Department of Medicine) ; Reddy, Srinivasa T. (University of California. Department of Medicine) ; Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. [...]
2016 - 10.1038/srep36387
Scientific Reports, Vol. 6 (November 2016) , art. 36387  
10.
10 p, 740.3 KB Ultrastable glasses portray similar behaviour to ordinary glasses at high pressure / Rodríguez Tinoco, Cristian (Universitat Autònoma de Barcelona. Departament de Física) ; González Silveira, Marta (Universitat Autònoma de Barcelona. Departament de Física) ; Barrio, Maria (Universitat Politècnica de Catalunya) ; Lloveras, Pol (Universitat Politècnica de Catalunya) ; Tamarit, Josep Lluis (Universitat Politècnica de Catalunya) ; Garden, Jean-Luc (Université Grenoble Alpes) ; Rodríguez Viejo, Javier (Universitat Autònoma de Barcelona. Departament de Física)
Pressure experiments provide a unique opportunity to unravel new insights into glass-forming liquids by exploring its effect on the dynamics of viscous liquids and on the evolution of the glass transition temperature. [...]
2016 - 10.1038/srep34296
Scientific Reports, Vol. 6 (October 2016) , art. 34296  

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