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13 p, 2.5 MB |
Graphene oxide nanosheets interact and interfere with SARS-CoV-2 surface proteins and cell receptors to inhibit infectivity
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Unal, Mehmet Altay (Ankara University. Stem Cell Institute (Turkey)) ;
Bayrakdar, Fatma (Ministry of Health General Directorate of Public Health. Microbiology References Laboratory (Turkey)) ;
Nazir, Hasan (Ankara University. Department of Chemistry (Turkey)) ;
Besbinar, Omur (Ankara University. Stem Cell Institute (Turkey)) ;
Gurcan, Cansu (Ankara University. Stem Cell Institute (Turkey)) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Arellano, Luis M. (Institut Català de Nanociència i Nanotecnologia) ;
Yalcin, Süleyman (Ministry of Health General Directorate of Public Health. Microbiology References Laboratory (Turkey)) ;
Panatli, Oguzhan (Ankara University. Department of Biomedical Engineering (Turkey)) ;
Celik, Dogantan (Ankara University. Stem Cell Institute (Turkey)) ;
Alkaya, Damla (Ankara University. Stem Cell Institute (Turkey)) ;
Agan, Aydan (Ankara University. Department of Biomedical Engineering (Turkey)) ;
Fusco, Laura (University of Padua. Department of Biomedical Sciences (Italy)) ;
Suzuk Yildiz, Serap (Ministry of Health General Directorate of Public Health. Microbiology References Laboratory (Turkey)) ;
Delogu, Lucia Gemma (University of Padua. Department of Biomedical Sciences (Italy)) ;
Akcali, Kamil Can (Ankara University. Stem Cell Institute (Turkey)) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Yilmazer, Acelya (Ankara University. Stem Cell Institute (Turkey))
Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID-19) acting both extracellularly and intracellularly to the host cells. Here, the aim is to explore graphene oxide (GO), the most studied 2D nanomaterial in biomedical applications, as a nanoscale platform for interaction with SARS-CoV-2. [...]
2021 -  10.1002/smll.202101483
Small, Vol. 17, Issue 25 (June 2021) , art. 2101483
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15 p, 4.6 MB |
Microfluidic in vitro platform for (nano)safety and (nano)drug efficiency screening
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Kohl, Yvonne (Fraunhofer Institute for Biomedical Engineering) ;
Biehl, Margit (Fraunhofer Institute for Biomedical Engineering) ;
Spring, Sarah (Fraunhofer Institute for Biomedical Engineering) ;
Hesler, Michelle (Fraunhofer Institute for Biomedical Engineering) ;
Ogourtsov, Vladimir (University College Cork. Tyndall National Institute) ;
Todorovic, Miomir (University College Cork. Tyndall National Institute) ;
Owen, Joshua (University of Leeds. Institute of Thermofluids) ;
Elje, Elisabeth (University of Oslo. Department of Molecular Medicine) ;
Kopecka, Kristina (Slovak Academy of Sciences. Biomedical Research Center) ;
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Dubaj, Tibor (Institute of Physical Chemistry and Chemical Physicsof SUT) ;
Rundén-Pran, Elise (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
William, Nicola (University of Leeds. School of Chemistry) ;
von Briesen, Hagen (Fraunhofer Institute for Biomedical Engineering) ;
Wagner, Sylvia (Fraunhofer Institute for Biomedical Engineering) ;
Kapur, Nikil (University of Leeds. Institute of Thermofluids) ;
Mariussen, Espen (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Nelson, Andrew (University of Leeds. School of Chemistry) ;
Gabelova, Alena (Slovak Academy of Sciences. Biomedical Research Center) ;
Dusinska, Maria (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Velten, Thomas (Fraunhofer Institute for Biomedical Engineering) ;
Knoll, Thorsten (Fraunhofer Institute for Biomedical Engineering)
Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal-free risk assessment of new chemicals and drugs. Microfluidic cell-based devices allow high-throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. [...]
2021 - 10.1002/smll.202006012
Small, Vol. 17, issue 15 (April 2021) , art. 2006012
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34 p, 1.2 MB |
Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin
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Díaz, Raquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Falgàs, Aïda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Under the unmet need of efficient tumor-targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22-mRTA-H6) is engineered to self-assemble as protein-only, CXCR4-targeted nanoparticles. [...]
2018 - 10.1002/smll.201800665
Small, Vol. 14, issue 26 (June 2018) , art. 1800665
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50 p, 4.9 MB |
Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing aAcute neurotoxicity : a pilot comparison to other nanomaterials
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Portioli, Corinne (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ;
Bussy, Cyrill (Lydia Becker Institute of Immunology and Inflammation) ;
Mazza, Mariarosa (The University of Manchester. Nanomedicine Lab.) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab.) ;
Prato, Maurizio (Ikerbasque) ;
Bianco, Alberto (CNRS. University of Strasbourg. Immunology, Immunopathology and Therapeutic Chemistry) ;
Bentivoglio, Marina (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Carbon-based nanomaterials (CNMs) are being explored for neurological applications. However, systematic in vivo studies investigating the effects of CNM nanocarriers in the brain and how brain cells respond to such nanomaterials are scarce. [...]
2020 - 10.1002/smll.202004029
Small, Vol. 16, issue 48 (Dec. 2020) , art. 2004029
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35 p, 2.0 MB |
Distortion-free sensing of neural activity using graphene transistors
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Garcia Cortadella, Ramon (Institut Català de Nanociència i Nanotecnologia) ;
Masvidal Codina, Eduard (Institut de Microelectrònica de Barcelona) ;
De la Cruz Sánchez, José M. (Institut Català de Nanociència i Nanotecnologia) ;
Schaefer, Nathan (Institut Català de Nanociència i Nanotecnologia) ;
Schwesig, Gerrit (Ludwig-Maximilians Universität München. Faculty of Medicine) ;
Jeschke, C. (Multi Channel Systems (MCS) GmbH) ;
Martínez-Aguilar, Javier (Institut de Microelectrònica de Barcelona) ;
Sánchez-Vives, María V (Institució Catalana de Recerca i Estudis Avançats) ;
Villa, Rosa (Institut de Microelectrònica de Barcelona) ;
Illa, Xavi (Institut de Microelectrònica de Barcelona) ;
Sirota, Anton (Ludwig-Maximilians Universität München. Faculty of Medicine) ;
Guimerà, Anton (Institut de Microelectrònica de Barcelona) ;
Garrido, Jose (Institut Català de Nanociència i Nanotecnologia)
Graphene solution-gated field-effect transistors (g-SGFETs) are promising sensing devices to transduce electrochemical potential signals in an electrolyte bath. However, distortion mechanisms in g-SGFET, which can affect signals of large amplitude or high frequency, have not been evaluated. [...]
2020 - 10.1002/smll.201906640
Small, Vol. 16, issue 16 (April 2020) , art. 1906640
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26 p, 681.2 KB |
Engineering protein nanoparticles out from components of the human microbiome
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López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Łoś, Marcin (University of Gdansk. Department of Bacterial Molecular Genetics (Poland)) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective binding to specific cell surface receptors and penetration into target cells require the use of targeting peptides. [...]
2020 - 10.1002/smll.202001885
Small, Vol. 16, Issue 30 (July 2020) , art. 2001885
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