UAB Digital Repository of Documents 3 records found  Search took 0.01 seconds. 
1.
12 p, 2.7 MB Selective delivery of T22-PE24-H6 to CXCR4 + diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model / Falgàs Comamala, Aïda (Institut d'Investigació Biomèdica Sant Pau) ; Pallarès, Víctor (Institut d'Investigació Biomèdica Sant Pau) ; Serna, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sierra, Jorge (Josep Carreras Leukaemia Research Institute (IJC)) ; Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alba Castellón, Lorena (Institut d'Investigació Biomèdica Sant Pau) ; Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ; Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ; Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
Background : Novel therapeutic strategies are urgently needed to reduce relapse rates and enhance survival in Diffuse Large B-Cell Lymphoma (DLBCL) patients. CXCR4-overexpressing cancer cells are good targets for therapy because of their association with dissemination and relapse in R-CHOP treated DLBCL patients. [...]
2020 - 10.7150/thno.43231
Theranostics, Vol. 10, Issue 12 (April 2020) , p. 5169-5180  
2.
18 p, 2.7 MB Immunization with the Gly 1127 -Cys 1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies / Bornachea, Olga (Institut d'Investigació Biomèdica Sant Pau) ; Benitez-Amaro, Aleyda (Institut d'Investigació Biomèdica Sant Pau) ; Vea, Angela (Institute of Biomedical Research of Barcelona (IIBB). Spanish National Research Council (CSIC), Barcelona, Spain) ; Nasarre, Laura (Institute of Biomedical Research of Barcelona (IIBB). Spanish National Research Council (CSIC), Barcelona, Spain) ; de Gonzalo-Calvo, David (Institut d'Investigació Biomèdica Sant Pau) ; Escola-Gil, Juan Carlos (Institut d'Investigació Biomèdica Sant Pau) ; Cedo, Lidia (Institut d'Investigació Biomèdica Sant Pau) ; Iborra, Antoni (SCAC, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain) ; Martínez-Martínez, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau) ; Camara, Juan Antonio (Preclinical Imaging Platform. Vall dHebron Institute of Research. Barcelona, Spain) ; Espinet, Carina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Borrell-Pages, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ; Castell, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Llorente-Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background : The LRP1 (CR9) domain and, in particular, the sequence Gly 1127 -Cys 1140 (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. [...]
2020 - 10.7150/thno.37305
Theranostics, Vol. 10 (february 2020) , p. 3263-3280  
3.
16 p, 2.9 MB In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia / Agulla, Jesús (Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Brea, David (Institut Germans Trias i Pujol) ; Campos, Francisco (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Sobrino, Tomás (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Argibay, Bárbara (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Al-Soufi, Wajih (4. Single Molecule Fluorescence Research Unit, Department of Physical Chemistry, Faculty of Science, University of Santiago de Compostela, E-27002 Lugo, Spain) ; Blanco, Miguel (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Castillo, José (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Ramos-Cabrer, Pedro (1. Department of Neurology, Neurovascular Area, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain) ; Universitat Autònoma de Barcelona
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the treatment of stroke, a leading cause of death and disability in developed countries. [...]
2013 - 10.7150/thno.7088
Theranostics, Vol. 4 (december 2013) , p. 90-105  

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