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29 p, 2.1 MB |
Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
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Navarro-Romero, Alba (Universitat Pompeu Fabra) ;
Galera-López, Lorena (Universitat Pompeu Fabra) ;
Ortiz-Romero, Paula (Universitat de Barcelona) ;
Llorente-Ovejero, Alberto (UPV Leioa) ;
de los Reyes-Ramírez, Lucía (Universitat Pompeu Fabra) ;
Bengoetxea de Tena, Iker (UPV Leioa) ;
Garcia-Elias, Anna (Universitat Pompeu Fabra) ;
Mas-Stachurska, Aleksandra (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Reixachs-Solé, Marina ;
Pastor, Antoni (Institut Hospital del Mar d'Investigacions Mèdiques) ;
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Maldonado, Rafael 1961- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Benito, Begoña (Hospital Universitari Vall d'Hebron) ;
Eyras, Eduardo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Puertas, Rafael (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Campuzano, Victoria (Universitat de Barcelona) ;
Ozaita, Andres (Universitat Pompeu Fabra) ;
Universitat Autònoma de Barcelona
Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. [...]
2022 -  10.7554/eLife.72560
eLife, Vol. 11 (october 2022)
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34 p, 3.4 MB |
Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection
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Kilinc, Murat (Departments of Neuroscience and Molecular Medicine) ;
Arora, Vineet (Departments of Neuroscience and Molecular Medicine) ;
Creson, Thomas K. (Departments of Neuroscience and Molecular Medicine) ;
Rojas, Camilo (Departments of Neuroscience and Molecular Medicine) ;
Le, Aliza A. (Department of Anatomy and Neurobiology. The University of California) ;
Lauterborn, Julie (Department of Anatomy and Neurobiology. The University of California) ;
Wilkinson, Brent (Zilkha Neurogenetic Institute. Keck School of Medicine. University of Southern California) ;
Hartel, Nicolas (Department of Chemical Engineering and Materials Science. University of Southern California) ;
Graham, Nicholas (Department of Chemical Engineering and Materials Science. University of Southern California) ;
Reich, Adrian (Bioinformatics and Statistics Core. The Scripps Research Institute) ;
Gou Alsina, Gemma (Universitat Autònoma de Barcelona) ;
Araki, Yoichi (Department of Neuroscience. Johns Hopkins University School of Medicine) ;
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau) ;
Coba, Marcelo P. (Zilkha Neurogenetic Institute. Keck School of Medicine. University of Southern California) ;
Lynch, Gary (Department of Anatomy and Neurobiology. The University of California) ;
Miller, Courtney A. (Departments of Neuroscience and Molecular Medicine) ;
Rumbaugh, Gumbaugh (Departments of Neuroscience and Molecular Medicine)
Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. [...]
2022 - 10.7554/eLife.75707
eLife, Vol. 11 (april 2022) , p. e75707
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3.
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25 p, 1.8 MB |
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
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Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron) ;
Suanzes, Paula (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. [...]
2022 - 10.7554/eLife.78294
eLife, Vol. 11 (may 2022)
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4.
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32 p, 13.6 MB |
The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane
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Lebecq, Alexis (Université de Lyon) ;
Doumane, Mehdi (Université de Lyon) ;
Fangain, Aurelie (Université de Lyon) ;
Bayle, Vincent (Université de Lyon) ;
Leong, Jia Xuan (University of Tübingen) ;
Rozier, Frédérique (Université de Lyon) ;
Marques-Bueno, Mar (Centre de Recerca en Agrigenòmica) ;
Armengot, Laia (Centre de Recerca en Agrigenòmica) ;
Boisseau, Romain (University of Montana. Division of Biological Science) ;
Simon, Mathilde Laetitia (Université de Lyon) ;
Franz-Wachtel, Mirita (University of Tübingen. Department of Quantitative Proteomics) ;
Macek, Boris (University of Tübingen. Department of Quantitative Proteomics) ;
Üstün, Suayib (Ruhr-University Bochum) ;
Jaillais, Yvon (Université de Lyon) ;
Caillaud, Marie-Cécile (Université de Lyon)
Membrane lipids, and especially phosphoinositides, are differentially enriched within the eukaryotic endomembrane system. This generates a landmark code by modulating the proper-ties of each membrane. [...]
2022 - 10.7554/eLife.73837
eLife, Vol. 11 (August 2022) , art. e73837
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5.
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19 p, 964.7 KB |
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness
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Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Desjobert, Cécile (Unité de Service et de Recherche) ;
Ponger, Loic (Sorbone University) ;
Lamant, Laurence (Université Toulouse III Paul Sabatier) ;
Bustos, Matias (Saint John's Cancer Institute) ;
Torres Ferreira, Jorge (Portuguese Oncology Institute of Porto) ;
Henrique, Rui (University of Porto) ;
Jeronimo, Carmen (University of Porto) ;
Lanfrancone, Luisa (Instituto Europeo di Oncologia) ;
Delmas, Audrey (Université Toulouse III Paul Sabatier) ;
Favre, Gilles (Université Toulouse III Paul Sabatier) ;
Daunay, Antoine (Fondation Jean Dausset-CEPH) ;
Busato, Florence (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Hoon, Dave S. B. (Saint John's Cancer Institute) ;
Tost, Jorg (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Etievant, Chantal (Unité de Service et de Recherche) ;
Riond, Joëlle (Université Toulouse III Paul Sabatier) ;
Arimondo, Paola Barbara (Institut Pasteur)
Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness, metastatic evolution, and patients' outcomes. [...]
2022 - 10.7554/eLife.78587
eLife, Vol. 11 (september 2022) , p. e78587
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41 p, 3.5 MB |
The Jurassic rise of squamates as supported by lepidosaur disparity and evolutionary rates
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Bolet, Arnau (Institut Català de Paleontologia Miquel Crusafont) ;
Stubbs, Thomas (University of Bristol. School of Earth Sciences) ;
Herrara-Flores, Jorge (University of Bristol. School of Earth Sciences) ;
Michael Benton, Michael (University of Bristol. School of Earth Sciences)
The squamates (lizards, snakes, and relatives) today comprise more than 10,000 species, and yet their sister group, the Rhynchocephalia, is represented by a single species today, the tuatara. The explosion in squamate diversity has been tracked back to the Cretaceous Terrestrial Revolution, 100 million years ago (Ma), the time when flowering plants began their takeover of terrestrial ecosystems, associated with diversification of coevolving insects and insect-eating predators such as lizards, birds, and mammals. [...]
2022 - 10.7554/eLife.66511
eLife, Vol. 11 (May 2022) , art. e66511
2 documentos
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13 p, 822.8 KB |
Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals
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Young, Rodrigo M. (University College London. Institute of Ophthalmology) ;
Solis, Camila J. (Diagnosis Biotech) ;
Barriga-Fehrman, Andres (Diagnosis Biotech) ;
Abogabir, Carlos (Diagnosis Biotech) ;
Thadani, Alvaro R. (Diagnosis Biotech) ;
Labarca, Mariana (Diagnosis Biotech) ;
Bustamante, Eva (Grupo Oncológico Cooperativo Chileno de Investigación) ;
Tapia, Cecilia V (Clínica Dávila) ;
Sarda, Antonia G. (Clínica Dávila) ;
Sepulveda, Francisca (Clínica Dávila) ;
Pozas, Nadia (Clínica Dávila) ;
Cerpa, Leslie C. (University of Chile. Department of Basic and Clinical Oncology) ;
Lavanderos, María A. (University of Chile. Department of Basic and Clinical Oncology) ;
Varela, Nelson M. (University of Chile. Department of Basic and Clinical Oncology) ;
Santibañez, Alvaro (Universidad de Chile. Programa Disciplinario de Inmunología) ;
Sandino, Ana María (Universidad de Santiago de Chile. Departamento de Biología) ;
Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Dixon, Garth (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Quiñones, Luis A. (University of Chile. Department of Basic and Clinical Oncology)
The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination efforts. [...]
2021 - 10.7554/eLife.70333
eLife, Vol. 10 (June 2021) , art. e70333
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8.
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17 p, 9.0 MB |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
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Cantero-Recasens, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso-Marañón, Josune (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lobo-Jarne, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Mar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Malhotra, Vivek (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by increasing mucins' secretion. [...]
2022 - 10.7554/eLife.73926
eLife, Vol. 11 (february 2022)
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9.
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19 p, 1.2 MB |
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
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Liu, Junke (University of Science and Technology, Wuhan, China) ;
Zhang, Zongyong (University of Science and Technology, Wuhan, China) ;
Moreno-Delgado, David (Université de Montpellier, France) ;
Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Rovira, Xavier (Université de Montpellier, France) ;
Trapero, Ana (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ;
Goudet, Cyril (Université de Montpellier, France) ;
Llebaria, Amadeu (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ;
Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Yuan, Qilin (University of Science and Technology, Wuhan, China) ;
Rondard, Philippe (Université de Montpellier, France) ;
Huang, Siluo (University of Science and Technology, Wuhan, China) ;
Liu, Jianfeng (University of Science and Technology, Wuhan, China) ;
Pin, Jean-Philippe (Université de Montpellier, France) ;
Universitat Autònoma de Barcelona.
Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. [...]
2017 - 10.7554/eLife.26985
eLife, Vol. 6 (august 2017)
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33 p, 2.5 MB |
UP-DOWN cortical dynamics reflect state transitions in a bistable network
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Jercog, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roxin, Alex (Centre de Recerca Matemàtica) ;
Barthó, Peter (MTA TTK NAP B. Research Group of Sleep Oscillations) ;
Luczak, Artur (University of Lethbridge. Canadian Center for Behavioural Neuroscience) ;
Compte, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de la Rocha, Jaime (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
In the idling brain, neuronal circuits transition between periods of sustained firing (UP state) and quiescence (DOWN state), a pattern the mechanisms of which remain unclear. Here we analyzed spontaneous cortical population activity from anesthetized rats and found that UP and DOWN durations were highly variable and that population rates showed no significant decay during UP periods. [...]
2017 - 10.7554/eLife.22425
eLife, Vol. 6 (August 2017) , art. e22425
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