A novel bio-functional material based on mammalian cell aggresomes - Search Results

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A novel bio-functional material based on mammalian cell aggresomes / Rodríguez-Carmona, Escarlata (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ruiz Cánovas, Eugènia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Abasolo, Ibane (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Schwartz Jr, Simó (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical and biotechnological interest, the physiological roles of these protein clusters and the functional status of the embedded proteins remain basically unexplored. [...]
2015 - DOI (Digital Object Identifier)

10.1007/s00253-015-6684-0
Applied microbiology and biotechnology, Vol. 99 Issue 17, p. 7079-7088 (Setembre 2015)

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