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1.
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9 p, 710.9 KB |
Single-injection nerve blocks for total knee arthroplasty : femoral nerve block versus femoral triangle block versus adductor canal block-a randomized controlled double-blinded trial
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Salvadores de Arzuaga, Carlos Ignacio (Hospital Universitari Vall d'Hebron) ;
Miguel, Marcos (Hospital Universitari Vall d'Hebron) ;
Biarnés, Alfons (Hospital Universitari Vall d'Hebron) ;
García, Marcelo (Hospital Universitari Vall d'Hebron) ;
Naya, José (Hospital Universitari Vall d'Hebron) ;
Khoudeir, Andrea (Hospital Universitari Vall d'Hebron) ;
Minguell-Monyart, Joan (Hospital Universitari Vall d'Hebron) ;
Pujol, Oriol (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Introduction: Femoral nerve block (FNB) is a well-established analgesic technique for TKA. However, it associates quadriceps weakness. Therefore, femoral triangle block (FTB) and adductor canal block (ACB) were proposed as effective alternative motor-spearing techniques. [...]
2023 -  10.1007/s00402-023-04960-5
Archives of Orthopaedic and Trauma Surgery, Vol. 143 Núm. 11 (november 2023) , p. 6763-6771
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2.
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17 p, 7.3 MB |
T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo
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Núñez, Yáiza (Institut d'Investigació Biomèdica Sant Pau) ;
Garcia-León, Annabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Falgàs, Aïda (Institut d'Investigació Biomèdica Sant Pau) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Garrido, Ana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sierra, Jorge (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug resistance. [...]
2023 - 10.3390/pharmaceutics15030727
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 727
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3.
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8 p, 677.2 KB |
A systems perspective on water markets : barriers, bright spots, and building blocks for the next generation
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Garrick, Dustin (University of Waterloo. Water Institute and School of Environment, Resources, and Sustainability) ;
Balasubramanya, Soumya (World Bank. Environment, Natural Resources and Blue Economy Global Practice) ;
Beresford, Melissa (San Jose State University. Department of Anthropology) ;
Wutich, Amber (Arizona State University. School of Human Evolution and Social Change and Center for Global Health) ;
Gilson, Gina G (University of Oxford. School of Geography and the Environment) ;
Jorgensen, Isabel (University of Waterloo. Water Institute and School of Environment, Resources, and Sustainability) ;
Brozovic, Nicholas (University of Nebraska. Department of Agricultural Economics) ;
Cox, Michael (Dartmouth College. Department of Environmental Studies) ;
Dai, Xiaoping (Hohai University. College of Agricultural Science and Engineering) ;
Erfurth, Sophie (University of Oxford. School of Geography and the Environment) ;
Rimšaitė, Renata (University of Nebraska) ;
Svensson, Jesper (University of Oxford. School of Geography and the Environment) ;
Jones, Julia Talbot (Victoria University of Wellington. School of Government) ;
Unnikrishnan, Hita (The University of Sheffield) ;
Wight, Charles ;
Villamayor Tomás, Sergio (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Mendoza, Karla Vazquez (The Nature Conservancy)
2023 - 10.1088/1748-9326/acb227
Environmental research letters, Vol. 18, Issue 3 (February 2023) , art. 31001
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4.
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18 p, 1.7 MB |
The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons
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Rivas-Santisteban, Rafael (Universitat de Barcelona. Institut de Neurociències) ;
Raïch, Iu (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Franco, Rafael (Universitat de Barcelona. Facultat de Química) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia)
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer's disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. [...]
2023 - 10.3390/cells12020283
Cells, Vol. 12 (january 2023)
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5.
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14 p, 2.4 MB |
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
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Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ;
Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ;
Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ;
Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ;
Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ;
Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ;
Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ;
Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ;
Gad, Helge (The University of Sheffield) ;
Visnes, Torkild (SINTEF Industry (Noruega)) ;
Helleday, Thomas (The University of Sheffield) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490
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15 p, 3.9 MB |
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases
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Sala, Rita (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rioja-Blanco, Elisa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Álamo, Patricia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Alba-Castellón, Lorena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. [...]
2022 - 10.1080/10717544.2022.2069302
Drug Delivery, Vol. 29 Núm. 1 (2022) , p. 1384-1397
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7.
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9 p, 5.0 MB |
A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB Receptor via the Lipid Bilayer
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Casajuana-Martin, Nil (Universitat Autònoma de Barcelona) ;
Navarro Brugal, Gemma (Instituto de Salud Carlos III) ;
Gonzalez, Angel (Universitat Autònoma de Barcelona) ;
Llinas del Torrent, Claudia (Universitat Autònoma de Barcelona) ;
Gómez-Autet, Marc (Universitat Autònoma de Barcelona) ;
Quintana García, Aleix (Universitat Autònoma de Barcelona) ;
Franco, Rafael (Instituto de Salud Carlos III) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona)
Molecular dynamic (MD) simulations have become a common tool to study the pathway of ligand entry to the orthosteric binding site of G protein-coupled receptors. Here, we have combined MD simulations and site-directed mutagenesis to study the binding process of the potent JWH-133 agonist to the cannabinoid CB receptor (CBR). [...]
2022 - 10.1021/acs.jcim.2c00865
Journal of Chemical Information and Modeling, Vol. 62 (october 2022) , p. 5771-5779
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8.
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11 p, 1.4 MB |
Microchromosomes are building blocks of bird, reptile, and mammal chromosomes
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Waters, Paul D. (UNSW Sydney. School of Biotechnology and Biomolecular Science) ;
Patel, Hardip R. (Australian National University. The John Curtin School of Medical Research) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Lister, Nicholas C. (UNSW Sydney. School of Biotechnology and Biomolecular Science) ;
Simakov, Oleg (University of Vienna. Department of Neurosciences and Developmental Biology) ;
Ezaz, Tariq (University of Canberra. Institute for Applied Ecology) ;
Kaur, Parwinder (The University of Western Australia. UWA School of Agriculture and Environment) ;
Frere, Celine (University of the Sunshine Coast (Australia)) ;
Grutzner, Frank (University of Adelaide. School of Biological Sciences (Australia)) ;
Georges, Arthur (University of Canberra. Institute for Applied Ecology) ;
Marshall Graves, Jennifer A. (La Trobe University. School of Life Sciences (Australia))
Microchromosomes, once considered unimportant shreds of the chicken genome, are gene-rich elements with a high GC content and few transposable elements. Their origin has been debated for decades. We used cytological and whole-genome sequence comparisons, and chromosome conformation capture, to trace their origin and fate in genomes of reptiles, birds, and mammals. [...]
2021 - 10.1073/pnas.2112494118
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 45 (November 2021) , art. e2112494118
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19 p, 4.1 MB |
Metal-Organic Polyhedra as Building Blocks for Porous Extended Networks
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Khobotov Bakishev, Akim (Institut Català de Nanociència i Nanotecnologia) ;
Hernández López, Laura (Institut Català de Nanociència i Nanotecnologia) ;
von Baeckmann, Cornelia (Institut Català de Nanociència i Nanotecnologia) ;
Albalad, Jorge (Institut Català de Nanociència i Nanotecnologia) ;
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)
Metal-organic polyhedra (MOPs) are a subclass of coordination cages that can adsorb and host species in solution and are permanently porous in solid-state. These characteristics, together with the recent development of their orthogonal surface chemistry and the assembly of more stable cages, have awakened the latent potential of MOPs to be used as building blocks for the synthesis of extended porous networks. [...]
2022 - 10.1002/advs.202104753
Advanced science, Vol. 9, Issue 11 (April 2022) , art. 2104753
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10 p, 646.8 KB |
Synthesis of polycarboxylate rhodium(II) metal-organic polyhedra (MOPs) and their use as building blocks for highly connected metal-organic frameworks (MOFs)
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Grancha, Thais (Institut Català de Nanociència i Nanotecnologia) ;
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia) ;
Zarekarizi, Farnoosh (Tarbiat Modares University. Department of Chemistry) ;
Hernández López, Laura (Institut Català de Nanociència i Nanotecnologia) ;
Albalad, Jorge (Institut Català de Nanociència i Nanotecnologia) ;
Khobotov Bakishev, Akim (Institut Català de Nanociència i Nanotecnologia) ;
Guillerm, Vincent (Institut Català de Nanociència i Nanotecnologia) ;
Morsali, Ali (Tarbiat Modares University. Department of Chemistry) ;
Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró) ;
Gándara, Felipe (Instituto de Ciencia de Materiales de Madrid) ;
Imaz, Inhar (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)
Use of preformed metal-organic polyhedra (MOPs) as supermolecular building blocks (SBBs) for the synthesis of metal-organic frameworks (MOFs) remains underexplored due to lack of robust functionalized MOPs. [...]
2021 - 10.1002/anie.202013839
Angewandte Chemie (International ed. Internet), Vol. 60, issue 11 (March 2021) , p. 5729-5733
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