Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis - Search Results

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Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis / Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ; Álvarez García, Mar (Centro de Biología Molecular Severo Ochoa) ; Marcelli, Bárbara (Centro de Biología Molecular Severo Ochoa) ; Andrés, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez, Miguel Ángel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Menéndez Arias, Luis (Centro de Biología Molecular Severo Ochoa)
HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. [...]
2015 - DOI (Digital Object Identifier)

10.1093/nar/gkv077
Nucleic acids research, Vol. 43 Núm. 4 (february 2015) , p. 2259

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