Interleukin-10 enhances the intestinal epithelial barrier in the presence of corticosteroids through p38 MAPK activity in Caco-2 monolayers a possible mechanism for steroid responsiveness in ulcerative colitis - Resultats de la cerca

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Interleukin-10 enhances the intestinal epithelial barrier in the presence of corticosteroids through p38 MAPK activity in Caco-2 monolayers : a possible mechanism for steroid responsiveness in ulcerative colitis / Lorén Moreno, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cabré i Gelada, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ojanguren, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pedrosa Tapias, Elisabet (Institut Germans Trias i Pujol) ; Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ; Mañosa i Ciria, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Manyé Almero, Josep (Institut Germans Trias i Pujol)
Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease. [...]
2015 - DOI (Digital Object Identifier)

10.1371/journal.pone.0130921
PloS one, Vol. 10, No 6 (June 2015) , p. e0130921

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