1.
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17 p, 2.3 MB |
Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity : Potential Involvement of Germ-Line microRNAs
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Ribas-Aulinas, Francesc (Institut de Recerca Sant Joan de Déu) ;
Ribo, Sílvia (Institut de Recerca Sant Joan de Déu) ;
Casas Masnou, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mourin-Fernandez, Marta (Institut de Recerca Sant Joan de Déu) ;
Ramon-Krauel, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Diaz, Ruben (Institut de Recerca Sant Joan de Déu) ;
Lerin, Carles (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Kalko, Susana G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vavouri, Tanya (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jimenez-Chillaron, Josep C. (School of Medicine. University of Barcelona)
Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. [...]
2023 - 10.3390/nu15051241
Nutrients, Vol. 15 Núm. 5 (march 2023) , p. 1241
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2.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulen, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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3.
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40 p, 552.6 KB |
Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex
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Portero Tresserra, Marta (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Gracia-Rubio, Irene (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Cantacorps, Lídia (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Pozo, Oscar J (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya)) ;
Gómez-Gómez, Alejandro (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya)) ;
Pastor, Antoni (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya)) ;
López-Arnau, Raúl (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
De La Torre, Rafael (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya)) ;
Valverde, Olga (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida)
Childhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which may increase the vulnerability to alcohol consumption during adolescence. [...]
2018 - 10.1016/j.euroneuro.2018.02.003
European neuropsychopharmacology, Vol. 28 Núm. 4 (2018) , p. 499-512
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4.
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13 p, 6.3 MB |
Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta
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Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Solé Piñol, Montserrat (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Serrano, Judith (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Taddeucci, Alice (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Perez, Belen (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Manich, Gemma (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Jimenez, Marcel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
D'Ocon, Pilar (Universitat de València) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Aims: Transient receptor potential vanilloid 2 (TRPV2) channels are expressed in both smooth muscle and endothelial cells and participate in vascular mechanotransduction and sensing of high temperatures and lipids. [...]
2024 - 10.1016/j.lfs.2023.122286
Life Sciences, Vol. 336 (2024)
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5.
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25 p, 4.8 MB |
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities
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Kakularam, Kumar R. (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ;
Canyelles-Niño, Miquel (Universitat Autònoma de Barcelona. Departament de Química) ;
Chen, Xin (Charité-Universitätsmedizin Berlin. Department of Biochemistry) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kuhn, Hartmut (Charité-Universitätsmedizin Berlin. Department of Biochemistry)
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy murinized the specificity of the human enzyme. [...]
2023 - 10.3390/ijms241210046
International journal of molecular sciences, Vol. 24, Issue 12 (June 2023) , art. 10046
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6.
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19 p, 4.3 MB |
Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A
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Manubens-Gil, Linus (Southeast University (SEU)) ;
Pons-Espinal, Meritxell (Universitat de Barcelona. Institut de Biomedicina) ;
Gener, Thomas (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros-Yañez, Inmaculada (Universidad de Castilla-La Mancha) ;
Martínez de Lagrán, María (Center for Genomic Regulation) ;
Dierssen, Mara (Biomedical Research Networking Center for Rare Diseases (CIBERER))
In this study, we investigated the impact of Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) overexpression, a gene associated with Down syndrome, on hippocampal neuronal deficits in mice. [...]
2024 - 10.1093/cercor/bhad431
Cerebral cortex (New York, N.Y.), Vol. 34, Issue 1, (January 2024) , art. bhad431
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7.
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9 p, 8.0 MB |
Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse
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Rapöhn, Inka (University of Leipzig) ;
Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Weiner, Juliane (University of Leipzig Medical Center) ;
Pujol, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kehr, Stephanie (Leipzig University) ;
Chadt, Alexandra (German Center for Diabetes Research) ;
Al-Hasani, Hadi (German Center for Diabetes Research) ;
Burkhardt, Ralph (University Hospital Regensburg) ;
Klöting, Nora (University of Leipzig) ;
Stumvoll, Michael (University of Leipzig) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kovacs, Peter (German Center for Diabetes Research) ;
Heiker, John T. (University of Leipzig Medical Center) ;
Breitfeld, Jana (Leipzig Medical Center)
Adipose tissue inflammation and insulin resistance are hallmarks in the development of metabolic diseases resulting from overweight and obesity, such as type 2 diabetes and non-alcoholic fatty liver disease. [...]
2023 - 10.3389/fendo.2023.1146454
Frontiers in Endocrinology, Vol. 14 (April 2023) , art. 1146454
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8.
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16 p, 3.7 MB |
Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy
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Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Wasek, Brandi (Baylor Scott & White Research Institute) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Harmon, Clinton (Baylor Scott & White Research Institute) ;
Arning, Erland (Baylor Scott & White Research Institute) ;
Bottiglieri, Teodoro (Baylor Scott & White Research Institute) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau leads to neurodegeneration and cognitive impairment remain unknown. [...]
2020 - 10.3390/metabo10020069
Metabolites, Vol. 10 Núm. 2 (february 2020) , p. 69
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9.
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13 p, 707.1 KB |
Effect of chromosomal reorganizations on morphological covariation of the mouse mandible : Insights from a Robertsonian system of Mus musculus domesticus
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Martínez-Vargas, Jessica (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Muñoz Muñoz, Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Medarde González, Núria Estel (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
López-Fuster, María José (Universitat de Barcelona. Departament de Biologia Animal) ;
Ventura Queija, Jacinto (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Introduction: Morphological integration and modularity depend on genetic covariation between traits, which emerges from pleiotropic effects of single loci and genetic linkage between loci. Since chromosomal reorganizations alter meiotic recombination, they might modify groups of linked genes and entail the fixation of new alleles with new pleiotropic effects. [...]
2014 - 10.1186/s12983-014-0051-3
Frontiers in Zoology, Vol. 11 (July 2014) , art. 51
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10.
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19 p, 1.6 MB |
Bridging mouse and human anatomies; a knowledge-based approach to comparative anatomy for disease model phenotyping
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Ruberte, Jesús (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Schofield, Paul N. (University of Cambridge, UK) ;
Sundberg, John P. (Vanderbilt University Medical Center, Nashville, USA) ;
Rodríguez Baeza, Alfonso (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Carretero i Romay, Ana (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
McKerlie, Colin (University of Toronto, Canada)
The laboratory mouse is the foremost mammalian model used for studying human diseases and is closely anatomically related to humans. Whilst knowledge about human anatomy has been collected throughout the history of mankind, the first comprehensive study of the mouse anatomy was published less than 60 years ago. [...]
2023 - 10.1007/s00335-023-10005-4
Mammalian Genome, Vol. 34, Num. 3 (july 2023) , p. 389-407
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