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Articles, 1 registres trobats
Articles 1 registres trobats  
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11 p, 547.9 KB The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids / Negrete, Roger (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Grup de Neurofarmacologia Molecular) ; Hervera Abad, Arnau (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Grup de Neurofarmacologia Molecular) ; Leánez, Sergi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Grup de Neurofarmacologia Molecular) ; Martín-Campos, Jesús M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Grup de Bioquímica) ; Pol Rigau, Olga (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Grup de Neurofarmacologia Molecular)
Background: Cannabinoid 2 receptor (CB2R) agonists attenuate inflammatory pain but the precise mechanism implicated in these effects is not completely elucidated. We investigated if the peripheral nitric oxide-cGMP-protein kinase G (PKG)-ATP-sensitive K+ (KATP) channels signaling pathway triggered by the neuronal nitric oxide synthase (NOS1) and modulated by opioids, participates in the local antinociceptive effects produced by a CB2R agonist (JWH-015) during chronic inflammatory pain. [...]
2011 - 10.1371/journal.pone.0026688
PLoS One, Vol. 6, Issue 10 (October 2011) , p. e26688  

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