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13 p, 4.1 MB Cytokine secretion requires phosphatidylcholine synthesis / Tian, Yong (St. Jude Children's Research Hospital. Department of Infectious Diseases) ; Pate, Caroline (St. Jude Children's Research Hospital. Department of Infectious Diseases) ; Garcia Andreolotti, Alberto (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Wang, Limin (St. Jude Children's Research Hospital. Department of Infectious Diseases) ; Tuomanen, Elaine (St. Jude Children's Research Hospital. Department of Infectious Diseases) ; Boyd, Kelli (St. Jude Children's Research Hospital. Animal Resource Center) ; Claro Izaguirre, Enrique (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Jackowski, Suzanne (St. Jude Children's Research Hospital. Department of Infectious Diseases)
Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway. Here, we demonstrate that CCTα-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex. [...]
2008 - 10.1083/jcb.200706152
The Journal of cell biology, Vol. 181, Num. 6 (June 2008) , p. 945-957  

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