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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 -  10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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2.
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15 p, 1.9 MB |
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer
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Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Dittmar, Gunnar (Luxembourg Institute of Health) ;
Nazarov, Petr V. (Luxembourg Institute of Health) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) mortality is directly associated with the presence of poor prognostic factors. Molecular prognostic factors have been identified, but none are used in clinical practice due to lack of validation studies. [...]
2021 - 10.3390/cancers13205052
Cancers, Vol. 13 (october 2021)
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3.
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre de Regulació Genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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4.
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176 p, 8.8 MB |
Biomarcadores angiogénicos en endometriosis
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Melnychuk Mykhaylevska, Taisiia ;
Colás Ortega, Eva, dir. ;
Gil Moreno, Antonio, 1965-, dir.
ANTECEDENTS: L'endometriosi empitjora la qualitat de vida i causa dolor pelvià crònic, especialment en dones joves. El retard en el diagnòstic pot trigar de mitjana uns 7 anys a causa de la manca d'eines de diagnòstic precoç, cosa que negativament impacta en el benestar de les pacients i en la fertilitat, tenint a més, alts costos econòmics i socials. [...]
ANTECEDENTES: La endometriosis empeora la calidad de vida y causa dolor pélvico crónico, especialmente en mujeres jóvenes. El retraso en el diagnóstico puede tardar de media unos 7 años debido a la falta de herramientas de diagnóstico tempranas, lo que negativamente impacta en el bienestar de las pacientes y en la fertilidad, teniendo, además, altos costes económicos y sociales. [...]
BACKGROUND: Endometriosis causes impaired quality of life and chronic pelvic pain, especially in young women. The diagnosis delay is around 7 years due to the lack of diagnostic tools, which causes negative impact in patient's welfare and fertility, and has high economic and social costs. [...]
2022
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5.
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278 p, 23.0 MB |
Approach to personalized medicine in endometrial cancer for the control of recurrent disease
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López Gil, Carlos ;
Colás Ortega, Eva, dir. ;
Gil Moreno, Antonio, 1965-, dir. ;
Comella i Carnicé, Joan Xavier, 1963-, dir.
El càncer d'endometri (CE) és el segon càncer ginecològic més freqüent a tot el món. En general, la majoria de les pacients es diagnostiquen en les primeres etapes de la malaltia amb una taxa de supervivència global a 5 anys del 95%. [...]
El cáncer de endometrio (CE) es el segundo cáncer ginecológico más frecuente a nivel mundial. En general, la mayoría de las pacientes son diagnosticadas en etapas tempranas de la enfermedad con una tasa de supervivencia a los 5 años del 95 %. [...]
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. In general, most patients are diagnosed at early stages of the disease with an overall 5-years survival rate of 95%. [...]
2022
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6.
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17 p, 2.5 MB |
Cervical Fluids Are a Source of Protein Biomarkers for Early, Non-Invasive Endometrial Cancer Diagnosis
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Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lesur, Antoine (Luxembourg Institute of Health) ;
Dittmar, Gunnar (University of Luxembourge) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Abnormal uterine bleeding (AUB) is the main symptom of endometrial cancer (EC), but it is highly nonspecific. This represents a huge burden for women's health, since all women presenting with bleeding will undergo sequential invasive tests, avoidable in 90-95% of those women who do not have EC. [...]
2023 - 10.3390/cancers15030911
Cancers, Vol. 15 (january 2023)
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7.
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10 p, 887.3 KB |
Relevance of Molecular Profiling in Patients With Low-Grade Endometrial Cancer
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Vrede, Stephanie W. (Canisius-Wilhelmina Hospital) ;
Kasius, Jenneke (Amsterdam Medical Centers and Center of Gynecologic Oncology Amsterdam) ;
Bulten, Johan (Radboud University Medical Center) ;
Teerenstra, Steven (Radboud University Medial Center) ;
Huvila, Jutta (University of Turku) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Boll, Dorry (Catharina Hospital Eindhoven, the Netherlands) ;
Vos, Maria Caroline (Elisabeth-Tweesteden Hospital) ;
van Altena, Anne M. (Radboud University Medical Center) ;
Asberger, Jasmin (Medical Center-University of Freiburg) ;
Sweegers, Sanne (Radboud University Medical Center) ;
van Weelden, Willem Jan (Canisius-Wilhelmina Hospital) ;
van der Putten, Louis J. M. (Radboud University Medical Center) ;
Amant, Frederic (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Visser, Nicole C. M. (Stichting Laboratory for Pathology and Medical Microbiology) ;
Snijders, Marc P. L. M. (Canisius-Wilhelmina Hospital) ;
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Hospital) ;
Kruitwagen, Roy (Maastricht University Medical Center) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Weinberger, Vit (University Hospital in Brno and Masaryk University) ;
Reijnen, Casper (Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Is tumor molecular profile associated with outcomes among patients with low-grade endometrial cancer? In this retrospective multicenter cohort study of 393 patients, outcomes for patients with low-grade endometrial cancer were not associated with molecular subgroup. [...]
2022 - 10.1001/jamanetworkopen.2022.47372
JAMA network open, Vol. 5 (december 2022)
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Shaping endometrial cancer diagnosis via the identification of protein biomarkers in gynecological fluids
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Coll de la Rubia, Eva ;
Gil-Moreno, Antonio, 1965-, dir. ;
Colás Ortega, Eva, dir. ;
Cabrera Díaz, Silvia, dir. ;
Comella i Carnicé, Joan Xavier, 1963-, dir.
El càncer d'endometri (CE) és el sisè tumor més comú en dones a tot el món, amb 417. 367 casos nous i 97. 370 morts el 2020. El diagnòstic precoç del CE s'associa amb el 95% de la taxa de supervivència als 5 anys, mentre que el diagnòstic avançat la redueix al 17%. [...]
El cáncer de endometrio (CE) es el sexto tumor más común en mujeres a nivel mundial, con 417. 367 nuevos casos y 97. 370 muertes en 2020. El diagnóstico temprano del CE se asocia con el 95% de la tasa de supervivencia a los 5 años, mientras que el diagnóstico avanzado la reduce hasta el 17%. [...]
Endometrial cancer (EC) is the sixth most common tumor in women worldwide, with 417,367 new cases and 97,370 deaths in 2020. Early diagnosis of EC is associated with 95% of 5-year survival rate, while advanced diagnosis drops the survival rate down to 17%. [...]
2022
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20 p, 10.3 MB |
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival
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Diéguez-Martínez, Nora (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Espinosa-Gil, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Yoldi Salinas, Guillermo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Megías-Roda, Elisabet (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bolinaga-Ayala, Idoia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Viñas-Casas, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Gorgisen, Gokhan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Domingo-Ortí, Inés (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Montoyo, Héctor (Ability Pharmaceuticals (Cerdanyola del Vallès)) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dolcet, Xavier (Universitat de Lleida) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Endometrial cancer (EC) is the most common type of gynecologic cancer in women of developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival of patients with high-risk EC tumors is poor, indicating a need for novel therapies. [...]
2022 - 10.1007/s00018-022-04541-6
Cellular and Molecular Life Sciences, Vol. 79 (2022) , p. 524
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16 p, 5.4 MB |
Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression
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Mota, Alba (Universidad Autónoma de Madrid. Departamento de Bioquímica) ;
Oltra, Sara S. (Centro de Investigación Biomédica en Red de Cáncer) ;
Selenica, Pier (Memorial Sloan Kettering Cancer Center) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casas-Arozamena, Carlos (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
López-Gil, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Diaz, Eva (MD Anderson International Foundation) ;
Gatius, Sonia (Hospital Arnau de Vilanova (València)) ;
Ruiz-Miro, María (Biobank (Lleida)) ;
Calvo, Ana (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Rojo-Sebastián, Alejandro (MD Anderson Cancer Center) ;
Hurtado Blanco, P (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Piñeiro, Health Research Institute of Santiago de Compostela ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center.) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Abal Posada, Miguel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Matias-Guiu, Xavier (Universitat de Lleida) ;
Weigelt, Britta (Memorial Sloan Kettering Cancer Center. Department of Pathology) ;
Moreno-Bueno, Gema (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Analyzing different tumor regions by next generation sequencing allows the assessment of intratumor genetic heterogeneity (ITGH), a phenomenon that has been studied widely in some tumor types but has been less well explored in endometrial carcinoma (EC). [...]
2022 - 10.1038/s41388-022-02221-0
Oncogene, Vol. 41 (february 2022) , p. 1835-1850
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