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15 p, 739.8 KB |
Advances in diagnostic tools for respiratory tract infections : from tuberculosis to COVID-19 - changing paradigms?
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Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonçalves-Carvalho, Filipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Respiratory tract infections (RTIs) are one of the most common reasons for seeking healthcare, but are amongst the most challenging diseases in terms of clinical decision-making. Proper and timely diagnosis is critical in order to optimise management and prevent further emergence of antimicrobial resistance by misuse or overuse of antibiotics. [...]
2022 -  10.1183/23120541.00113-2022
ERJ Open Research, Vol. 8 (september 2022)
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8 p, 120.0 KB |
Microbiologia [100771]
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Julián Gómez, Esther ;
Herrero Abadía, Paula ;
Lacoma De la Torre, Alicia ;
Universitat Autònoma de Barcelona.
Facultat de Biociències
Es tracta d'una assignatura obligatòria del grau de Biologia, que introdueix als/a les estudiants en el món microbià, donant una visió general dels microorganismes, en connexió amb la resta d'éssers vius i amb els diferents ambients en els quals viuen els microorganismes. [...]
This is a compulsory subject of the degree of Biology, which introduces students to the microbial world, giving a general vision of microorganisms, in connection with other living beings and the different environments in which microorganisms live. [...]
Se trata de una asignatura obligatoria del grado de Biología, que introduce a los estudiantes en el mundo microbiano, dando una visión general de los microorganismos, en conexión con el resto de seres vivos y con los diferentes ambientes en los que viven los microorganismos. [...]
2023-24
Grau en Biologia [812]
3 documents
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3.
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11 p, 1.5 MB |
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
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Wheatley, Rachel M. (University of Oxford, Department of Biology) ;
Caballero, Julio Diaz (University of Oxford, Department of Biology) ;
van der Schalk, Thomas E. (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
De Winter, Fien H. R. (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Shaw, Liam P. (University of Oxford, Department of Biology) ;
Kapel, Natalia (University of Oxford, Department of Biology) ;
Recanatini, Claudia (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Kluytmans, Jan (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Esser, Mark (Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Oliver, Antonio (Institut d'Investigació Sanitària Illes Balears, Hospital Universitari Son Espases) ;
Kumar-Singh, Samir (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Craig MacLean, R. (University of Oxford, Department of Biology)
Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. [...]
2022 - 10.1038/s41467-022-34101-2
Nature communications, Vol. 13 (november 2022)
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4.
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14 p, 899.9 KB |
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
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Safont, G. (Universitat Autònoma de Barcelona) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Stojanovic, Zorac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Cano, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona) ;
Molina-Moya, Bárbara (Universitat Autònoma de Barcelona) ;
Solis, Alan Jhurior (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arméstar, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz-Fernández, Sergio (Universitat Autònoma de Barcelona) ;
Cendón Esteve, Arnau (Universitat Autònoma de Barcelona) ;
Sokalchuk, Liliya (Universitat Autònoma de Barcelona) ;
Tolosa, Guillermo (Diagnostic and Research in Immunodeficiencies Jeffrey Modell Center. Cytometry and Cellular Culture Area. La Frontera University) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Universitat Autònoma de Barcelona)
The measurement of specific T-cell responses can be a useful tool for COVID-19 diagnostics and clinical management. In this study, we evaluated the IFN-γ T-cell response against the main SARS-CoV-2 antigens (spike, nucleocapsid and membrane) in acute and convalescent individuals classified according to severity, and in vaccinated and unvaccinated controls. [...]
2022 - 10.3390/jcm11175103
Journal of clinical medicine, Vol. 11 Núm. 17 (september 2022) , p. 5103
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5.
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12 p, 1.6 MB |
Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and Stratifying Staphylococcus aureus Infections
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Montagut, Enrique-J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Acosta, Gerardo (Institut de Química Avançada de Catalunya) ;
Albericio, Fernando (University of KwaZulu-Natal) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht, Utrecht University) ;
Salvador, Juan-Pablo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
An immunochemical strategy to detect and quantify AIP-IV, the quorum sensing (QS) signaling molecule produced by Staphylococcus aureus agr type IV, is reported here for the first time. Theoretical calculations and molecular modeling studies have assisted on the design and synthesis of a suitable peptide hapten (AIPIVS), allowing to obtain high avidity and specific antibodies toward this peptide despite its low molecular weight. [...]
2022 - 10.1021/acsinfecdis.1c00670
ACS infectious diseases, Vol. 8 (02 2022) , p. 645-656
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6.
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15 p, 2.0 MB |
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. [...]
2022 - 10.1038/s41598-022-07018-5
Scientific reports, Vol. 12 (March 2022) , art. 3374
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9 p, 3.2 MB |
Exploring the evolution and epidemiology of European CC1-MRSA-IV : tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone
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Earls, Megan R. (University of Dublin) ;
Steinig, Eike J. (Australian Institute of Tropical Health and Medicine) ;
Monecke, Stefan (InfectoGnostics Research Campus Jena) ;
Samaniego Castruita, José Alfredo (Copenhagen University Hospital) ;
Simbeck, Alexandra (University Hospital Regensburg) ;
Schneider-Brachert, Wulf (University Hospital Regensburg) ;
Vremerǎ, Teodora (University of Medicine and Pharmacy "Grigore T Popa") ;
Dorneanu, Olivia S. (University of Medicine and Pharmacy "Grigore T Popa") ;
Loncaric, Igor (University of Veterinary Medicine Vienna) ;
Bes, Michèle (Institut des Agents Infectieux) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Wernery, Ulrich (Central Veterinary Research Laboratory) ;
Armengol-Porta, Marc (Dresden Municipal Hospital) ;
Blomfeldt, Anita (Akershus University Hospital) ;
Duchene, Sebastian (University of Melbourne) ;
Bartels, Mette D. (Copenhagen University Hospital) ;
Ehricht, Ralf (Friedrich-Schiller University) ;
Coleman, David C. (University of Dublin) ;
Universitat Autònoma de Barcelona
This study investigated the evolution and epidemiology of the community-associated and multidrug-resistant clone European CC1-MRSA-IV. Whole-genome sequences were obtained for 194 European CC1-MRSA-IV isolates (189 of human and 5 of animal origin) from 12 countries, and 10 meticillin-susceptible precursors (from North-Eastern Romania; all of human origin) of the clone. [...]
2021 - 10.1099/mgen.0.000601
Microbial Genomics, Vol. 7 (july 2021)
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8.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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9.
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1.2 MB |
Impact of Host Genetics and Biological Response Modifiers on Respiratory Tract Infections
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Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mateo, Lourdes (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Méndez, María Jesús (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Rodrigo Gonzalo de Líria, Carlos (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villar-Hernandez, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Host susceptibility to respiratory tract infections (RTI) is dependent on both genetic and acquired risk factors. Repeated bacterial and viral RTI, such as pneumonia from encapsulated microorganisms, respiratory tract infections related to respiratory syncytial virus or influenza, and even the development of bronchiectasis and asthma, are often reported as the first symptom of primary immunodeficiencies. [...]
2019 - 10.3389/fimmu.2019.01013
Frontiers in immunology, Vol. 10 (may 2019)
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10.
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14 p, 2.1 MB |
Dysfunctional accessory gene regulator (agr) as a prognostic factor in invasive Staphylococcus aureus infection : a systematic review and meta-analysis
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Lee, Soon Ok (Pusan National University Hospital, Republic of Korea) ;
Lee, Shinwon (Pusan National University Hospital, Republic of Korea) ;
Lee, Jeong Eun (Pusan National University Hospital, Republic of Korea) ;
Song, Kyoung-Ho (Seoul National University College of Medicine and Seoul National University Bundang Hospital, Republic of Korea) ;
Kang, Chang Kyung (Seoul National University College of Medicine and Seoul National University Hospital, Republic of Korea) ;
Wi, Yu Mi (Sungkyunkwan University School of Medicine, Republic of Korea) ;
San-Juan, Rafael (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
López-Cortés, Luis E. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jang, Hee-Chang (Chonnam National University Medical School. Department of Infectious Diseases, Republic of Korea) ;
Kim, Eu Suk (Seoul National University College of Medicine and Seoul National University Bundang Hospital, Republic of Korea) ;
Kim, Hong Bin (Seoul National University College of Medicine and Seoul National University Bundang Hospital, Republic of Korea) ;
Lee, Sun Hee (Pusan National University Hospital, Republic of Korea)
The accessory gene regulator (agr) locus of Staphylococcus aureus is a quorum-sensing virulence regulator. Although there are many studies concerning the effect of dysfunctional agr on the outcomes of S. [...]
2020 - 10.1038/s41598-020-77729-0
Scientific reports, Vol. 10 (november 2020)
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