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3.5 MB Mecanismes moleculars que participen en la regulació de la Sex Hormone-Binding Globulin : factors nutricionals i fibrosi hepàtica / Brianso-Llort, Laura ; Martínez Selva, David, dir. ; Hernández Pascual, Cristina, dir. ; Simó Canonge, Rafael, dir. ; Meseguer Navarro, Ana, dir.
La globulina transportadora d'hormones sexuals (SHBG) és una glicoproteïna homodimèrica sèrica produïda pel fetge que uneix amb gran afinitat i especificitat als esteroides sexuals i en regula la seva biodisponibilitat. [...]
La globulina transportadora de hormonas sexuales (SHBG) es una glicoproteína homodimérica sérica producida por el hígado que une con gran afinidad y especificidad a esteroides sexuales regulando su biodisponibilidad. [...]
Sex Hormone-Binding Globulin (SHBG) is a glycoprotein secreted by the liver into the blood where it binds and transports sex steroids with high affinity and specificity and regulates its bioavailability. [...]

2022  
2.
12 p, 11.3 MB Diabetes Protects from Prostate Cancer by Downregulating Androgen Receptor : New Insights from LNCaP Cells and PAC120 Mouse Model / Barbosa-Desongles, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Torres, Inés (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Munell Casadesus, Francina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Poupon, Marie-France (Institut Curie) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez Selva, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Type 2 diabetes has been associated with decreased risk of prostate cancer in observational studies, and this inverse association has been recently confirmed in several large cohort studies. However the mechanisms involved in this protective effect remain to be elucidated. [...]
2013 - 10.1371/journal.pone.0074179
PloS one, Vol. 8 (september 2013)  
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8 p, 629.6 KB Thyroid Hormone Upregulates Zinc-α-glycoprotein Production in the Liver but Not in Adipose Tissue / Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sáez-López, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Selva, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona. Departament de Medicina
Overproduction of zinc-α-glycoprotein by adipose tissue is crucial in accounting for the lipolysis occurring in cancer cachexia of certain malignant tumors. The main aim of this study was to explore whether thyroid hormone could enhance zinc-α-glycoprotein production in adipose tissue. [...]
2014 - 10.1371/journal.pone.0085753
PloS one, Vol. 9 (january 2014)  
4.
14 p, 1.9 MB Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor : a new Contribution to the French Paradox / Saez-Lopez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brianso-Llort, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torres-Torrenteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hammond, Geoffrey L. (Cellular & University of British Columbia) ; Martínez Selva, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production. [...]
2017 - 10.1038/s41598-017-12509-x
Scientific reports, Vol. 7 (september 2017)  
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1 p, 658.7 KB Author Correction : Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox / Saez-Lopez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brianso-Llort, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torres-Torronteras, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hammond, Geoffrey L. (University of British Columbia. Cellular & Physiological Sciences) ; Martínez Selva, David (Hospital Universitari Vall d'Hebron. Institut de Recerca)
2018 - 10.1038/s41598-018-23159-y
Scientific reports, Vol. 8 (march 2018)  
6.
6 p, 431.4 KB Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity / Ramon-Krauel, Marta (Institut de Recerca Sant Joan de Déu) ; Leal-Witt, María Jesús (Institut de Recerca Sant Joan de Déu) ; Osorio-Conles, Óscar (Institut de Recerca Sant Joan de Déu) ; Amat-Bou, Montse (Institut de Recerca Sant Joan de Déu) ; Lerin, Carles (Institut de Recerca Sant Joan de Déu) ; Martínez Selva, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. [...]
2021 - 10.1186/s40348-021-00113-z
Molecular and Cellular Pediatrics, Vol. 8 (march 2021)  
7.
11 p, 1.9 MB Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone-Binding Globulin / Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barbosa-Desongles, Anna ; Lecube, Albert ; Hernández, Cristina ; Martínez Selva, David ; Universitat Autònoma de Barcelona
Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. [...]
2012 - 10.2337/db11-0727
Diabetes, Vol. 61 (january 2012) , p. 372-382  
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211 p, 6.5 MB Mecanismos moleculares que regulan la expresión de la shbg: implicaciones en la obesidad / Sáez López, Cristina ; Martínez Selva, David, dir. ; Hernández, Cristina, dir. ; Simó Canonge, Rafael, dir. ; Comella i Carnicé, Joan Xavier, 1963-, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
La proteína transportadora de esteroides sexuales (SHBG) se sintetiza en el hígado humano y es secretada a la sangre, donde une con gran afinidad andrógenos y estrógenos, regulando su biodisponibilidad y accesibilidad a nivel de tejido. [...]
Sex Hormone-Binding Globulin (SHBG) is synthesized by human liver and secreted into the blood, where it binds with high affinity androgens and estrogens, regulating their bioavailability and accesibility at tissue level. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
9.
40 p, 261.5 KB Accions alternatives de la proteïna transportadora d'esteroids sexuals (SHBG/ABP) a l'espermatogènesi i al càncer de pròstata / Martínez Selva, David ; Munell Casadesus, Francina, dir. ; Reventós i Puigjaner, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
La finalitat d'aquesta tesi ha estat la d'estudiar les funcions alternatives de la proteïna transportadora d'esteroids sexuals (SHBG/ABP) a l'espermatogènesi i al càncer de pròstata. 1) A l'espermatogènesi s'ha treballat amb dos models diferents, un és el ratolí transgènic que sobreexpressa la SHBG/ABP de rata i l'altre el ratolí transgènic que sobreexpressa la SHBG/ABP humana. [...]
The aim of this thesis is to study the alternative funcions of the sex hormone-binding globulin / androgen-binding protein (SHBG/ABP) during the espermatogenesis and prostate cancer. 1) In the study of the espermatogenesis we have used two different models: the transgenic mice overexpressing the rat SHBG/ABP, and the transgenic mice overexpressing the human SHBG/ABP. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2002
3 documents

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