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1.
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11 p, 330.9 KB |
Asthma control conundrum in clinical practice - Data from a two-stage Delphi survey and literature review
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Canonica, G. Walter (Humanitas University) ;
Spanevello, Antonio (Università degli Studi dell'Insubria) ;
Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Blakey, John D (Curtin University) ;
Garcia, Gabriel (Hospital R Rossi) ;
Inoue, Hiromasa (Kagoshima University) ;
Dalcolmo, Margareth (Reference Center Hélio Fraga) ;
Yang, Dong (Fudan University) ;
Mokashi, Soniya (GlaxoSmithKline) ;
Kurne, Abhishek (Global Medical Affairs) ;
Butta, Aman Kapil (GSK Asia House) ;
Universitat Autònoma de Barcelona
Definitions and measures of asthma control used in clinical trials and practice often vary, as highlighted in the manuscript, "Is asthma control more than just an absence of symptoms? An expert consensus statement". [...]
2023 -  10.1016/j.dib.2023.109422
Data in brief, Vol. 50 (july 2023)
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2.
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4 p, 334.8 KB |
Asthma-COPD overlap is not a homogeneous disorder : Further supporting data
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Pérez-de-Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Cosio, Borja G. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Iglesias, Amanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de las Cuevas, Natividad (Hospital 12 de Octubre (Madrid)) ;
Soler-Cataluña, Juan Jose (Hospital Arnau de Vilanova (València)) ;
Izquierdo, Jose Luis (Hospital Universitario de Guadalajara) ;
López-Campos, Jose Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Calero, Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Torrego, Alfons (Institut d'Investigació Biomèdica Sant Pau) ;
Moragón, Eva Martínez (Hospital Universitari Doctor Peset (València)) ;
Soriano, Joan B. (Universidad Autónoma de Madrid) ;
Viña, Antolin Lopez (Hospital Puerta de Hierro (Madrid)) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. [...]
2017 - 10.1186/s12931-017-0667-x
Respiratory Research, Vol. 18 Núm. 1 (february 2017) , p. 183
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3.
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10 p, 1.8 MB |
A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
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Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid)) ;
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Torres, Juan Pablo (Queen's University) ;
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
García-Rivero, J. L. (Hospital de Laredo) ;
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid)) ;
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Cosio, Borja G (Clínica Quirón-Rotger) ;
Universitat Autònoma de Barcelona
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. [...]
2020 - 10.2147/COPD.S263430
International journal of COPD, Vol. 15 (2020) , p. 2091-2100
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4.
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12 p, 330.8 KB |
A new Therapeutic approach based on a reinterpretation of asthma control
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Pérez de Llano, Luis (Hospital Universitario de Lucus Augusti, EOXI Lugo) ;
Entrenas, Luis Manuel (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Carrascosa, M. Inés (Hospital de Urduliz Alfredo Espinosa) ;
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca)) ;
Almonacid, Carlos (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Abascal-Bolado, Beatriz (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Montoro, Francisco Javier (Hospital de Llíria, Valencia;) ;
Sogo, Ana Isabel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
The concept of asthma control is fundamental because it establishes a target for treatment, but despite the diversity of definitions, a high proportion of patients fail to achieve it. In this article, we highlight the shortcomings of the current concept of control by discussing aspects such as the differences between patient- and physician-perceived control and the limitations of the tools used to assess it. [...]
2023 - 10.23866/BRNRev:2023-M0089
BRN Review, Vol. 9 Núm. 2 (2023)
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5.
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9 p, 461.9 KB |
Is asthma control more than just an absence of symptoms? : An expert consensus statement
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Canonica, G. Walter (Humanitas University) ;
Spanevello, Antonio (Università degli Studi dell'Insubria. Dipartimento di Medicina e Chirurgia) ;
Pérez de Llano, Luis (Instituto de Investigación Sanitaria Santiago de Compostela) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Blakey, John D. (Curtin University of Technology) ;
Garcia, Gabriel (Hospital R. Rossi. Servicio de Neumología (Argentina)) ;
Inoue, Hiromasa (Kagoshima University. Department of Pulmonary Medicine) ;
Dalcolmo, Margareth (Fundação Oswaldo Cruz (Brazil)) ;
Yang, Dong (Fudan University. Zhongshan Hospital (China)) ;
Mokashi, Soniya (GSK Brentford (UK)) ;
Kurne, Abhishek (Global Medical Affairs (Singapore)) ;
Butta, Aman Kapil (GSK (Singapore)) ;
Universitat Autònoma de Barcelona
PURPOSE: Definitions and measures of asthma control used in clinical trials and in clinical practice vary considerably. There is also misalignment between patients and healthcare professionals (HCPs) in terms of understanding and managing asthma control. [...]
2022 - 10.1016/j.rmed.2022.106942
Respiratory Medicine, Vol. 202 (October 2022) , art. 106942
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6.
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7 p, 1.3 MB |
The Response to Biologics is Better in Patients with Severe Asthma Than in Patients with Asthma-COPD Overlap Syndrome
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Pérez de Llano, Luis (Pneumology Service. Hospital Lucus Augusti. EOXI Lugo. Cervo e Monforte) ;
Dacal Rivas, David (Hospital Universitario Lucus Augusti (Lugo)) ;
Malanda, Nuria Marina (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Gullón, José Antonio (Hospital Universitario Lucus Augusti (Lugo)) ;
Muñoz-Esquerre, Mariana (Institut d'Investigació Biomèdica de Bellvitge) ;
García-Moguel, Ismael (Allergy Service) ;
Díaz Campos, Rocío Magdalena (Hospital Universitario) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
Harbenau Mena, Alicia (Hospital de Mérida) ;
Cosio, Borja G (Institut d'Investigació Sanitària Illes Balears) ;
Padilla, Alicia (Hospital Costa del Sol (Marbella)) ;
Cisneros, Carolina (Hospital Universitario de la Princesa (Madrid))
Although biologics have demonstrated to be effective in T2-high asthma patients, there is little experience with these drugs in asthma-COPD overlap (ACO). The aim of this study was to compare the effectiveness of biologics in these two conditions. [...]
2022 - 10.2147/JAA.S338467
Journal of Asthma and Allergy, Vol. 15 (2022) , p. 363-369
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7.
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14 p, 3.8 MB |
dIvergEnt : How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies
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Palomares, Óscar (Universidad Complutense de Madrid) ;
Sánchez-Ramón, Silvia (Universidad Complutense de Madrid. Departamento de Microbiología y Parasitología) ;
Dávila, Ignacio (Instituto de Investigación Biomédica de Salamanca) ;
Prieto, Luis (Hospital Universitari Doctor Peset (València)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Lleonart, Marta (Novartis Farmacéutica (Espanya)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Nieto, Antonio (Hospital Universitari i Politècnic La Fe (València)) ;
Universitat Autònoma de Barcelona
Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. [...]
2017 - 10.3390/ijms18061328
International journal of molecular sciences, Vol. 18 (june 2017)
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8.
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11 p, 429.6 KB |
Effectiveness of Text Message Reminders on Adherence to Inhaled Therapy in Patients With Asthma : Prospective Multicenter Randomized Clinical Trial
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Almonacid, Carlos (University of Alcala de Henares. Instituto Ramón y Cajal de Investigación Sanitaria. Department of Respiratory Medicine) ;
Melero, Carlos (Hospital Universitario 12 de Octubre (Madrid)) ;
López Viña, Antolín (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Cisneros, Carolina (Hospital Universitario de la Princesa (Madrid)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
García-Rivero, Juan Luis (Laredo Hospital. Department of Respiratory Medicine) ;
Romero Falcón, Auxiliadora (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ramos, Jacinto (Hospital Universitario de Salamanca) ;
Bazús González, Teresa (Hospital Universitario Central de Asturias) ;
Andrés Prado, María (Hospital Universitario Fundación Jiménez Díaz) ;
Muriel, Alfonso (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Universitat Autònoma de Barcelona
Poor adherence to inhaled medication in asthma patients is of great concern. It is one of the main reasons for inadequate asthma control. The goal of the research was to determine if motivational messages using short message service (SMS, or text) improved adherence to inhaled medication in patients with asthma. [...]
2021 - 10.2196/12218
JMIR Formative Research, Vol. 5 (february 2021)
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9.
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9 p, 537.0 KB |
Efficacy and Safety of Reslizumab in Patients with Severe Asthma with Inadequate Response to Omalizumab : A Multicenter, Open-Label Pilot Study
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Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Cosio, Borja G. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Domingo, Christian (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Urrutia, Isabel (Hospital de Galdakao (Usansolo, Biscaia)) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Entrenas Costa, Luis M. (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Marina Malanda, Nuria (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Prieto Andrés, Luis (Hospital Universitari Doctor Peset (València)) ;
Alvarez-Gutiérrez, Francisco J. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Background: Patients with severe allergic and eosinophilic asthma could qualify for different biologic therapies. Objective: To evaluate the efficacy and safety of weight-based intravenous reslizumab dosing in patients who have previously failed therapy with omalizumab. [...]
2019 - 10.1016/j.jaip.2019.01.017
The Journal of allergy and clinical immunology. In practice, Vol. 7 Núm. 7 (september 2019) , p. 2277-2283.e2
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10.
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11 p, 1.3 MB |
Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap : a network approach
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Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Cosio, Borja G.. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Iglesias, Amanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de las Cuevas, Natividad (Hospital Universitario 12 de Octubre (Madrid)) ;
Soler-Cataluña, Juan Jose (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Izquierdo, Jose Luis (Hospital Universitario de Guadalajara) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Calero, Carmen (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Plaza, Vicente (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Torrego, Alfons (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martinez-Moragon, Eva (Hospital Universitari Doctor Peset (València)) ;
Soriano, Joan B.. (Instituto de Investigación Hospital Universitario de la Princesa) ;
Viña, Antolin Lopez (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona)
The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. [...]
2018 - 10.2147/COPD.S153694
International journal of COPD, Vol. 13 (february 2018) , p. 591-601
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