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11.
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12 p, 1.6 MB |
Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and Stratifying Staphylococcus aureus Infections
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Montagut, Enrique-J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Acosta, Gerardo (Institut de Química Avançada de Catalunya) ;
Albericio, Fernando (University of KwaZulu-Natal) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht, Utrecht University) ;
Salvador, Juan-Pablo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
An immunochemical strategy to detect and quantify AIP-IV, the quorum sensing (QS) signaling molecule produced by Staphylococcus aureus agr type IV, is reported here for the first time. Theoretical calculations and molecular modeling studies have assisted on the design and synthesis of a suitable peptide hapten (AIPIVS), allowing to obtain high avidity and specific antibodies toward this peptide despite its low molecular weight. [...]
2022 -  10.1021/acsinfecdis.1c00670
ACS infectious diseases, Vol. 8 (02 2022) , p. 645-656
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12.
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15 p, 2.0 MB |
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. [...]
2022 - 10.1038/s41598-022-07018-5
Scientific reports, Vol. 12 (March 2022) , art. 3374
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13.
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9 p, 3.2 MB |
Exploring the evolution and epidemiology of European CC1-MRSA-IV : tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone
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Earls, Megan R. (University of Dublin) ;
Steinig, Eike J. (Australian Institute of Tropical Health and Medicine) ;
Monecke, Stefan (InfectoGnostics Research Campus Jena) ;
Samaniego Castruita, José Alfredo (Copenhagen University Hospital) ;
Simbeck, Alexandra (University Hospital Regensburg) ;
Schneider-Brachert, Wulf (University Hospital Regensburg) ;
Vremerǎ, Teodora (University of Medicine and Pharmacy "Grigore T Popa") ;
Dorneanu, Olivia S. (University of Medicine and Pharmacy "Grigore T Popa") ;
Loncaric, Igor (University of Veterinary Medicine Vienna) ;
Bes, Michèle (Institut des Agents Infectieux) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Wernery, Ulrich (Central Veterinary Research Laboratory) ;
Armengol-Porta, Marc (Dresden Municipal Hospital) ;
Blomfeldt, Anita (Akershus University Hospital) ;
Duchene, Sebastian (University of Melbourne) ;
Bartels, Mette D. (Copenhagen University Hospital) ;
Ehricht, Ralf (Friedrich-Schiller University) ;
Coleman, David C. (University of Dublin) ;
Universitat Autònoma de Barcelona
This study investigated the evolution and epidemiology of the community-associated and multidrug-resistant clone European CC1-MRSA-IV. Whole-genome sequences were obtained for 194 European CC1-MRSA-IV isolates (189 of human and 5 of animal origin) from 12 countries, and 10 meticillin-susceptible precursors (from North-Eastern Romania; all of human origin) of the clone. [...]
2021 - 10.1099/mgen.0.000601
Microbial Genomics, Vol. 7 (july 2021)
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14.
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11 p, 1.7 MB |
Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo-Garcia, José Luis (Basque Research and Technology Alliance) ;
Gautier, Jacqueline (Hôpital Saint-Damien (Haití)) ;
Doresca, Mariette Jean Coute (Hôpital Saint-Damien (Haití)) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Santiveri, Clara M. (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Abellana, Rosa (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. [...]
2021 - 10.1038/s41598-021-91545-0
Scientific reports, Vol. 11 (june 2021)
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15.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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16.
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17.
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7 p, 1.6 MB |
Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts
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Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernandez-Figueras, M. Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí, Mercè (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. [...]
2015 - 10.1186/s13287-015-0101-6
Stem cell research & therapy, Vol. 6 (may 2015)
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18.
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13 p, 503.0 KB |
Microbiological testing of adults hospitalised with community-acquired pneumonia : an international study
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Carugati, Manuela (Ospedale Maggiore Policlinico Milano) ;
Aliberti, Stefano (Università degli Studi di Milano) ;
Reyes, Luis Felipe (Universidad de La Sabana, Chia, Colombia) ;
Franco Sadud, Ricardo (University of Central Florida, USA) ;
Irfan, Muhammad (Aga Khan University, Karachi, Pakistan) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soni, Nilam J. (University of Texas Health San Antonio, USA) ;
Faverio, Paola (University of Milan Bicocca) ;
Gori, Andrea (Università degli Studi di Milano) ;
Blasi, Francesco (Università degli Studi di Milano) ;
Restrepo, Marcos I. (University of Texas Health San Antonio, USA)
This study aimed to describe real-life microbiological testing of adults hospitalised with community-acquired pneumonia (CAP) and to assess concordance with the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) and 2011 European Respiratory Society (ERS) CAP guidelines. [...]
2018 - 10.1183/23120541.00096-2018
ERJ Open Research, Vol. 4 (october 2018)
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19.
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13 p, 4.9 MB |
Head-to-head comparison of two engineered cardiac grafts for myocardial repair : From scaffold characterization to pre-clinical testing
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jorba, Ignasi (Universitat de Barcelona) ;
Segú-Vergés, Cristina (Anaxomics Biotech) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navajas, Daniel (Universitat de Barcelona) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. [...]
2018 - 10.1038/s41598-018-25115-2
Scientific reports, Vol. 8 (april 2018)
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20.
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1 p, 662.5 KB |
Author Correction : Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico
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Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
2018 - 10.1038/s41598-018-24808-y
Scientific reports, Vol. 8 (april 2018)
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