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1.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 -  10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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2.
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13 p, 2.4 MB |
Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker
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Izquierdo-Garcia, José Luis (Universidad Complutense de Madrid) ;
Comella-del-Barrio, Patricia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Fuentes, Maria Angeles (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Adela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra-Vidal, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Casas, Xavier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Herzmann, Christian (Research Center Borstel. Center for Clinical Studies, Germany) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Despite efforts to improve tuberculosis (TB) detection, limitations in access, quality and timeliness of diagnostic services in low- and middle-income countries are challenging for current TB diagnostics. [...]
2020 - 10.1038/s41598-020-78999-4
Scientific reports, Vol. 10 (december 2020)
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3.
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11 p, 1.8 MB |
Diagnostic benefits of adding EspC, EspF and Rv2348-B to the QuantiFERON Gold In-tube antigen combination
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Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Blauenfeldt, Thomas (Statens Serum Institut) ;
García-García, Esther (Universitat Autònoma de Barcelona) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalvá, Adrian (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, J. (Hospital Universitari Vall d'Hebron) ;
Jiménez, M. A. (Hospital Universitari Vall d'Hebron) ;
Centeno Clemente, Carmen Angela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel D. (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat Aymerich, Cristina (Utrecht University) ;
Andersen, Peter Lawætz (Statens Serum Institut) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Ruhwald, Morten (Statens Serum Institut) ;
Domínguez, Jose (Universitat Autònoma de Barcelona)
Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. [...]
2020 - 10.1038/s41598-020-70204-w
Scientific reports, Vol. 10 (august 2020)
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4.
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11 p, 1.7 MB |
Use of IP-10 detection in dried plasma spots for latent tuberculosis infection diagnosis in contacts via mail
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Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez, María A. (Hospital Universitari Vall d'Hebron) ;
Ruiz Manzano, J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, Jose (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Díaz, Yoel D. (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Molina-Pinargote, Israel (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruhwald, Morten (Statens Serum Institut (Copenhagen, Dinamarca). Department of Infectious Disease Immunology) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to test the use of IP-10 detection in dried plasma from contact studies individuals (contacts of smear positive patients), by comparing it with IP-10 and IFN-γ detection in direct plasma, to establish IP-10 detection in DPS as a useful assay for LTBI diagnosis. [...]
2019 - 10.1038/s41598-019-40778-1
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3943
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5.
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11 p, 1.2 MB |
Study of CD27 and CCR4 markers on specific CD4+ T-cells as immune tools for active and latent tuberculosis management
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Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vila, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María A. (Hospital Universitari Vall d'Hebron) ;
Centeno, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israael (Serveis Clínics. Unitat Clínica de Tractament Directament Observat de la Tuberculosi) ;
González-Díaz, Yoel D. (Serveis Clínics. Unitat Clínica de Tractament Directament Observat de la Tuberculosi) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Luque-Chacón, Lydia (Hospital de Sant Joan Despí Moisès Broggi) ;
Sabriá, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The immunological characterization of different cell markers has opened the possibility of considering them as immune tools for tuberculosis (TB) management, as they could correlate with TB latency/disease status and outcome. [...]
2019 - 10.3389/fimmu.2018.03094
Frontiers in immunology, Vol. 9 (Jan. 2019) , art. 3094
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6.
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125 p, 6.8 MB |
Características clínicas, etiológicas y pronóstico de los pacientes con neumonía adquirida en la comunidad (NAC) y sepsis grave al ingreso
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Montull Veiga, Beatriz ;
Menéndez Villanueva, Rosario, dir. ;
Ruiz Manzano, J., dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
La neumonía adquirida en la comunidad (NAC) es un tipo infección respiratoria con elevada tasa de complicaciones y mortalidad sobre todo en los casos que asocian sepsis grave, siendo un problema grave de salud a nivel mundial. [...]
Community adquired pneumonia (CAP) is a respiratory infection with higher rate of complications and increased mortality, especially in those cases associated with severe sepsis which is a serious health problem worldwide. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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7.
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168 p, 16.9 MB |
La ultrasonografia endobronquial en l'estudi del mediastí neoplàsic
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Serra Mitjà, Pere ;
Andreo García, Felipe, dir. ;
Sanz Santos, J. Luis 1969-, (José Luis) dir. ;
Ruiz Manzano, J., dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
La present Tesi Doctoral es basa en tres articles que avaluen la idoneïtat de la ultrasonografia endobronquial amb punció aspirativa transbronquial (USEB-PATB) en l'estudi del mediastí neoplàsic, tant d'origen pulmonar com extra-pulmonar. [...]
The present doctoral thesis is based on three articles that evaluate the accuracy of endobronchial ultrasonography with transbronchial needle aspiration in the study of the mediastinum, both pulmonary and extra-pulmonary origin. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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8.
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9.
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7 p, 1.1 MB |
PyroTyping, a novel pyrosequencing-based assay for Mycobacterium tuberculosis genotyping
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Molina-Moya, Barbara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Sierra, N. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, S. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Haba, L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Samper, S. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Ruiz Manzano, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arnold, C. (Genomic Services and Development Unit, Public Health England) ;
Domínguez, J.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
We developed a novel method, PyroTyping, for discrimination of Mycobacterium tuberculosis isolates combining pyrosequencing and IS6110 polymorphism. A total of 100 isolates were analysed with IS6110-restriction fragment length polymorphism (RFLP), spoligotyping, mycobacterial interspersed repetitive units - variable number tandem repeats (MIRU-VNTR), and PyroTyping. [...]
2017 - 10.1038/s41598-017-06760-5
Scientific reports, Vol. 7 Núm. 6777 (july 2017) , p. 1-7
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10.
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23 p, 4.5 MB |
Novel approach to continuous adventitious respiratory sound analysis for the assessment of bronchodilator response
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Lozano García, Manuel (Institut de Bioenginyeria de Catalunya) ;
Fiz, José Antonio (Institut de Bioenginyeria de Catalunya) ;
Martínez Rivera, Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Torrents, Aurora (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jané Campos, Raimon (Institut de Bioenginyeria de Catalunya)
Background. A thorough analysis of continuous adventitious sounds (CAS) can provide distinct and complementary information about bronchodilator response (BDR), beyond that provided by spirometry. Nevertheless, previous approaches to CAS analysis were limited by certain methodology issues. [...]
2017
PloS one, february 2017, p. 1-23
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