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15 p, 3.6 MB |
Unraveling the genetics of transformed splenic marginal zone lymphoma
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Grau, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
López, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navarro, Alba (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Frigola, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Nadeu, Ferran (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clot, Guillem (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bastidas-Mora, Gabriela (Hospital Clínic i Provincial de Barcelona) ;
Alcoceba, Miguel (Hospital Universitario de Salamanca) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blanes, Margarita (Hospital General Universitario de Elda) ;
Colomer, Dolors (Hospital Clínic i Provincial de Barcelona) ;
Costa, Dolors (Hospital Clínic i Provincial de Barcelona) ;
Domingo-Domenech, Eva (Institut d'Investigació Biomèdica de Bellvitge) ;
Enjuanes, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Escoda, Lourdes (Hospital Universitari Joan XXIII de Tarragona) ;
Forcada, Pilar (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Giné, Eva (Hospital Clínic i Provincial de Barcelona) ;
Lopez-Guerra, Mónica (Hospital Clínic i Provincial de Barcelona) ;
Ramón, Olga (Hospital General de Igualada) ;
Rivas-Delgado, Alfredo (Hospital Clínic i Provincial de Barcelona) ;
Folch, Laura Vicente (Consorci Sanitari de Terrassa) ;
Wotherspoon, Andrew (Royal Marsden NHS Foundation Trust, United Kingdom) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
López-Guillermo, Armando (Hospital Clínic i Provincial de Barcelona) ;
Matutes, Estella (Hospital Clínic i Provincial de Barcelona) ;
Bea, Sílvia (Hospital Clínic i Provincial de Barcelona)
The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL) transformation are not well defined. We studied 41 patients with SMZL that eventually underwent large B-cell lymphoma transformation. [...]
2023 -  10.1182/bloodadvances.2022009415
Blood advances, Vol. 7 Núm. 14 (july 2023) , p. 3695-3709
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10 p, 4.1 MB |
Clinico-biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation
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Bastidas-Mora, Gabriela (Hospital Clínic i Provincial de Barcelona) ;
Bea, Sílvia (Centro de Investigación Biomédica en Red de Cáncer) ;
Navarro, Alba (Centro de Investigación Biomédica en Red de Cáncer) ;
Gine, Eva (Centro de Investigación Biomédica en Red de Cáncer) ;
Costa, Dolors (Centro de Investigación Biomédica en Red de Cáncer) ;
Delgado, Julio (Centro de Investigación Biomédica en Red de Cáncer) ;
Baumann, Tycho (Hospital Universitario 12 de Octubre (Madrid)) ;
Magnano, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rivas-Delgado, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villamor, Neus (Centro de Investigación Biomédica en Red de Cáncer) ;
Colomer, Dolors (Centro de Investigación Biomédica en Red de Cáncer) ;
Lopez-Guerra, Mónica (Centro de Investigación Biomédica en Red de Cáncer) ;
Rozman, Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Balagué, Olga (Centro de Investigación Biomédica en Red de Cáncer) ;
Martínez, Daniel (Centro de Investigación Biomédica en Red de Cáncer) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Escoda, Lourdes (Hospital Universitari Joan XXIII de Tarragona) ;
Alcoceba, Miguel (Hospital Universitario de Salamanca) ;
Blanes, Margarita (Hospital General Universitario de Elda) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Campo, Elias (Centro de Investigación Biomédica en Red de Cáncer) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust) ;
López Guillermo, Armando (Centro de Investigación Biomédica en Red de Cáncer) ;
Matutes, Estella (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
We describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL-T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL-T in other centres. [...]
2022 - 10.1111/bjh.17815
British Journal of Haematology, Vol. 196 Núm. 1 (january 2022) , p. 146-155
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9 p, 1.7 MB |
KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust) ;
Hahne, Jens Claus (The Institute of Cancer Research) ;
Vlachogiannis, George (The Institute of Cancer Research) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust) ;
Lampis, Andrea (The Institute of Cancer Research) ;
Braconi, Chiara (The Institute of Cancer Research) ;
Kalaitzaki, Eleftheria (The Royal Marsden NHS Foundation Trust) ;
De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust) ;
Capdevila Castillón, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Glimelius, Bengt (University of Uppsala) ;
Tarazona, Noelia (Universitat de València) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust) ;
Lote, Hazel (The Institute of Cancer Research) ;
Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust) ;
Mentrasti, Giulia (The Institute of Cancer Research) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust) ;
Tait, Diana (The Royal Marsden NHS Foundation Trust) ;
Oates, Jacqueline (The Royal Marsden NHS Foundation Trust) ;
Valeri, Nicola (The Institute of Cancer Research) ;
Universitat Autònoma de Barcelona
There are limited data on circulating, cell-free, tumour (ct)DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd)PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX ± cetuximab in a randomised phase II trial. [...]
2018 - 10.1038/s41598-018-19212-5
Scientific reports, Vol. 8 (january 2018)
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8 p, 196.5 KB |
Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer
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Sclafani, Francesco (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Brown, Gina (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Cunningham, David (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Wotherspoon, Andrew (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Mendes, Larissa Sena Teixeira (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Balyasnikova, Svetlana (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Evans, Jessica (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Peckitt, Clare (Clinical Research & Development, The Royal Marsden NHS Foundation Trust) ;
Begum, Ruwaida (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tait, Diana (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tabernero, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Glimelius, Bengt (Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, University of Uppsala) ;
Roselló, Susana (Department of Haematology and Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia) ;
Thomas, Janet (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Oates, Jacqui (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Chau, Ian (Department of Medicine, The Royal Marsden NHS Foundation Trust)
Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). [...]
2017 - 10.1038/bjc.2017.320
British Journal of Cancer, Vol. 117 (09 2017) , p. 1478-1485
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6 p, 1.4 MB |
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Lampis, Andrea (The Institute of Cancer Research. Department of Molecular Pathology) ;
Hahne, Jens Claus (The Institute of Cancer Research. Department of Molecular Pathology) ;
Ghidini, Michele (The Institute of Cancer Research. Department of Molecular Pathology) ;
Lote, Hazel (The Institute of Cancer Research. Department of Molecular Pathology) ;
Zito, Domenico (The Institute of Cancer Research. Department of Molecular Pathology) ;
Tabernero, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Glimelius, Bengt (University of Uppsala. Genetics and Pathology, Experimental and Clinical Oncology. Department of Immunology) ;
Cervantes, Andrés (University of Valencia. Biomedical Research Institute INCLIVA. Department of Haematology and Medical Oncology) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Wilson, Sanna Hulkki (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Peckitt, Clare (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Tait, Diana (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Oates, Jacqueline (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Braconi, Chiara (The Institute of Cancer Research. Department of Cancer Therapeutics) ;
Valeri, Nicola (The Institute of Cancer Research. Department of Molecular Pathology) ;
Universitat Autònoma de Barcelona
Analysis of a polymorphism in mature microRNA-608 (rs4919510) in rectal cancer patients enrolled in a randomized phase II clinical trial identified patient subpopulations who might benefit from the use of an intensified neo-adjuvant treatment strategy with Cetuximab. [...]
2016 - 10.1093/carcin/bgw073
Carcinogenesis, Vol. 37 (july 2016) , p. 852-857
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6 p, 225.1 KB |
Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer : results of the EXPERT-C trial
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Peckitt, C. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Lampis, Andrea (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Hahne, Jens Claus (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Braconi, Chiara (The Institute of Cancer Research. Division of Cancer Therapeutics (UK)) ;
Tabernero, Josep (Hospital Universitari Vall d'Hebron) ;
Glimelius, B. (University of Uppsala. Department of Immunology, Genetics and Pathology (Sweden)) ;
Cervantes, Andrés (Universitat de València. Departament d'Hematologia i Oncologia Mèdica) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
González De Castro, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Tait, D. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Oates, J. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Valeri, Nicola (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Universitat Autònoma de Barcelona
Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. A single-nucleotide polymorphism (rs61764370, T > G base substitution) in the let-7 complementary site 6 (LCS-6) of KRAS mRNA has been shown to predict prognosis in early-stage colorectal cancer (CRC) and benefit from anti-epidermal growth factor receptor monoclonal antibodies in metastatic CRC. [...]
2015 - 10.1093/annonc/mdv285
Annals of oncology, Vol. 26, Issue 9 (September 2015) , p. 1936-1941
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