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135 p, 1.9 MB |
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias : An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
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Lewczuk, Piotr (University Hospital of Białystok) ;
Riederer, Peter (University Hospital Würzburg) ;
O'Bryant, Sid E. (University of North Texas Health Science Center) ;
Verbeek, Marcel M. (Radboud Alzheimer center) ;
Dubois, Bruno (Salpêtrièrie Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Jellinger, Kurt A. (Institute of Clinical Neurobiology) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Ramirez, Alfredo (University of Cologne) ;
Parnetti, Lucilla (University of Perugia) ;
Jack Jr, Clifford R. (Mayo Clinic) ;
Teunissen, Charlotte E. (VU University Medical Center Amsterdam) ;
Hampel, Harald (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Jessen, Frank (German Center for Neurodegenerative Disorders (DZNE)) ;
Glodzik, Lidia (NYU Langone Medical Center) ;
de Leon, Mony J. (NYU Langone Medical Center) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Jansen, Willemijn J. (Maastricht University) ;
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Andreasson, Ulf (The Sahlgrenska Academy at the University of Gothenburg) ;
Otto, Markus (University of Ulm) ;
Mollenhauer, Brit (Kassel and University Medical Center Göttingen) ;
Wiltfang, Jens (University of Aveiro) ;
Turner, Martin R. (University of Oxford) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Handels, Ron (Karolinska Institutet (Estocolm, Suècia)) ;
Thompson, Alexander G. (University of Oxford) ;
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia)) ;
Ermann, Natalia (Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Karaca, Ilker (University of Bonn) ;
Wagner, Holger (University of Bonn) ;
Oeckl, Patrick (University of Ulm) ;
van Waalwijk van Doorn, Linda (Radboud Alzheimer center) ;
Bjerke, Maria (University of Antwerp) ;
Kapogiannis, Dimitrios (National Institute on Aging/National Institutes of Health (NIA/NIH)) ;
Kuiperij, H.Bea (Radboud Alzheimer center) ;
Farotti, Lucia (University of Perugia) ;
Li, Yi (NYU Langone Medical Center) ;
Gordon, Brian A. (Washington University School of Medicine) ;
Epelbaum, Stéphane (Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A)) ;
Vos, Stephanie J.B. (Maastricht University) ;
Klijn, Catharina J.M. (Radboud Alzheimer Center) ;
Van Nostrand, William E. (Stony Brook University) ;
Minguillon, Carolina (Fundació Pasqual Maragall) ;
Schmitz, Matthias (University Medical School) ;
Gallo, Carla (Universidad Peruana Cayetano Heredia) ;
Lopez Mato, Andrea (Maimonides University) ;
Thibaut, Florence (University Hospital Cochin-Site Tarnier 89 rue d'Assas) ;
Lista, Simone (heimer (IM2A). Hôpital Pitié-Salpêtrière) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Kornhuber, Johannes (Universitätsklinikum Erlangen) ;
Universitat Autònoma de Barcelona
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. [...]
2018 -  10.1080/15622975.2017.1375556
World Journal of Biological Psychiatry, Vol. 19 Núm. 4 (19 2018) , p. 244-328
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9 p, 745.8 KB |
The EMIF-AD Multimodal Biomarker Discovery study : Design, methods and cohort characteristics
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Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (Katholieke Universiteit Leuven) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Engelborghs, Sebastiaan (University of Antwerp) ;
Frisoni, Giovanni (IRCCS Instituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Fundació Pasqual Maragall) ;
Wallin, Anders (Institute of Neuroscience and Physiology) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Baird, Alison (University of Oxford) ;
Dobson, Richard (NIHR University College London Hospitals) ;
Legido-Quigley, Cristina (King's College London) ;
Sleegers, Kristel (University of Antwerp) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Bertram, Lars (University of Oslo) ;
Ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Barkhof, Frederik (Amsterdam UMC. University Medical Center) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Lovestone, Simon (University of Oxford) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study. [...]
2018 - 10.1186/s13195-018-0396-5
Alzheimer's research & therapy, Vol. 10 Núm. 1 (june 2018) , p. 64
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13 p, 828.8 KB |
Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions
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Villatoro, Sergi (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-de-las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri-Ramírez, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón-Ibañez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Moya-Horno, Irene (Hospital General de Catalunya) ;
García-Peláez, Beatrtiz (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Malapelle, Umberto (University of Naples Federico II) ;
Balada-Bel, Ariadna (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Campos, Raquel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Remei (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Blasco, Ana (Hospital General Universitari de València) ;
Catalán, María J. (Grup Quirónsalud (Barcelona, Catalunya)) ;
González, Xavier (Hospital General de Catalunya) ;
Troncone, Giancarlo (University of Naples Federico II) ;
Karachaliou, Niki (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations and guide treatment decisions. [...]
2019 - 10.1002/1878-0261.12574
Molecular Oncology, Vol. 13 Núm. 12 (january 2019) , p. 2633-2645
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18 p, 2.0 MB |
Establishing In-House Cutoffs of CSF Alzheimer's Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort
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Orellana, Adelina (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
García-gonzález, Pablo (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Rosende-roca, Maitee (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Vargas, Liliana (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Esteban de Antonio, Ester (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Narvaiza, Leire (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pytel, Vanesa (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, Marta. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Background: Clinical diagnosis of Alzheimer's disease (AD) increasingly incorporates CSF biomarkers. However, due to the intrinsic variability of the immunodetection techniques used to measure these biomarkers, establishing in-house cutoffs defining the positivity/negativity of CSF biomarkers is recommended. [...]
2022 - 10.3390/ijms23136891
International journal of molecular sciences, Vol. 23 Núm. 13 (july 2022) , p. 6891
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15 p, 1.2 MB |
Kynurenic acid levels are increased in the CSF of Alzheimer's disease patients
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González-Sánchez, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Jiménez, Javier (Universidad de Alcalá) ;
Narváez García, Arantzazu (Universidad de Alcalá) ;
Antequera, Desiree (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Llamas-Velasco, Sara (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Herrero San-Martín, Alejandro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Molina Arjona, Jose Antonio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Lopez de Munain, Adolfo (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ;
Rodríguez-Núñez, Montserrat (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ;
Pérez-Martínez, David Andrés (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Villarejo-Galende, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Bartolome, Fernando (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Domínguez, Elena (Universidad de Alcalá) ;
Carro, Eva M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer's disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. [...]
2020 - 10.3390/biom10040571
Biomolecules, Vol. 10 Núm. 4 (april 2020) , p. 571
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14 p, 1.6 MB |
Characteristics of subjective cognitive decline associated with amyloid positivity
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Janssen, Olin (Maastricht University. School for Mental Health and Neuroscience) ;
Jansen, W.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Vos, S.J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Parnetti, Lucilla (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Gabryelewicz, T. (Department of Neurodegenerative Disorders. Mossakowski Medical Research Centre. Polish Academy of Sciences) ;
Fladby, T. (Department of Neurology. Akershus University Hospital) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villeneuve, S. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Hort, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Epelbaum, S. (Inserm Sorbonne Université. Inria. Aramis project-team. Paris Brain Institute - Institut du Cerveau (ICM)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel. (VUB) Brussels. and University of Antwerp) ;
van der Flier, W.M. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Landau, S. (Helen Wills Neuroscience Institute. University of California) ;
Popp, J. (Old Age Psychiatry. University Hospital of Lausanne) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Scheltens, P. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Rikkert, M.O. (Department of Geriatric Medicine. Radboud Alzheimer Center. Radboud University Medical Center) ;
Snyder, P.J. (Kingston. The University of Rhode Island) ;
Rowe, C. (Department of Molecular Imaging & Therapy. Austin Health) ;
Chételat, G.. (Institut National de la Santé et de la Recherche Médicale (Inserm)) ;
Ruíz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chipi, E. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Wolfsgruber, S. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Heneka, M. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Boecker, H. (Functional Neuroimaging Group. Department of Radiology. University Hospital Bonn) ;
Peters, O. (Charité - Universitätsmedizin Berlin) ;
Jarholm, J. (Department of Neurology. Akershus University Hospital) ;
Rami, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tort-Merino, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Binette, A.P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Poirier, J. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Rosa-Neto, P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Cerman, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Dubois, B. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Teichmann, M. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau) ;
Ebenau, J. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Pocnet, C. (Old Age Psychiatry. University Hospital of Lausanne) ;
Eckerström, M. (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Thompson, L. (Kingston. The University of Rhode Island) ;
Villemagne, V. (Department of Psychiatry. University of Pittsburgh) ;
Buckley, R. (Brigham and Women's Hospital and Department of Neurology Massachusetts General Hospital. Harvard Medical School) ;
Burnham, S. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Delarue, M. (Institut National de la Sant. et de la Recherche M.dicale (Inserm)) ;
Freund-Levi, Yvonne (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet) ;
Wallin, Å.K. (Department of Clinical Sciences Malmö. Clinical Memory Research Unit. Lund University) ;
Ramakers, I. (Maastricht University. School for Mental Health and Neuroscience) ;
Tsolaki, Magda (Memory and Dementia Center. 3rd Department of Neurology. "G Papanicolau. " General Hospital. Aristotle University of Thessaloniki) ;
Soininen, H. (Institute of Clinical Medicine. Neurology. University of Eastern Finland) ;
Hampel, H. (GRC no 21. Alzheimer Precision Medicine (AMP). AP-HP. Pitié-Salpêtrière Hospital. Sorbonne University) ;
Spiru, L. (Geriatrics- Gerontology and Old Age Psychiatry. Alzheimer Unit. Ana Aslan International Foundation - Memory Center and Longevity Medicine) ;
Tijms, B. (Maastricht University. School for Mental Health and Neuroscience) ;
Ossenkoppele, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Verhey, F.R.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Jessen, F. (German Center For Neurodegenerative Diseases/Clinical Research. Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE). Zentrum für klinische Forschung/AG) ;
Visser, P.J. (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet)
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. [...]
2022 - 10.1002/alz.12512
Alzheimer's & Dementia, Vol. 18 Núm. 10 (october 2022) , p. 1832-1845
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19 p, 1.3 MB |
State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
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Hampel, Harald (Eisai Inc. Neurology Business Group) ;
Shaw, Leslie M. (Perelman School of Medicine. Department of Pathology and Laboratory Medicine. University of Pennsylvania) ;
Aisen, Paul (USC Alzheimer's Therapeutic Research Institute) ;
Chen, Christopher (Memory Aging and Cognition Centre. Departments of Pharmacology and Psychological Medicine. Yong Loo Lin School of Medicine. National University of Singapore) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Iwatsubo, Takeshi (Department of Neuropathology. Graduate School of Medicine. The University of Tokyo) ;
Iwata, Atsushi (Tokyo Metropolitan Geriatric Hospital) ;
Yamada, Masahito (Department of Neurology and Neurobiology of Aging. Kanazawa University Graduate School of Medical Science) ;
Ikeuchi, Takeshi (Department of Molecular Genetics. Brain Research Institute. Niigata University) ;
Jia, Jianping (Innovation Center for Neurological Disorders. Department of Neurology. Xuan Wu Hospital. Capital Medical University) ;
Wang, Huali (Dementia Care and Research Center. Peking University Institute of Mental Health (Sixth Hospital). Beijing Dementia Key Lab. National Clinical Research Center for Mental Disorders) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Peskind, Elaine (VA Northwest Mental Illness Research. Education and Clinical Center. VA Puget Sound Health Care System. Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital) ;
Cummings, Jeffrey (Chambers-Grundy Center for Transformative Neuroscience. Department of Brain Health. School of Integrated Health Sciences. University of Nevada Las Vegas (UNLV)) ;
Vergallo, Andrea (Eisai Inc. Neurology Business Group) ;
Universitat Autònoma de Barcelona
Recent advances in developing disease-modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health-care systems toward biomarker-guided early detection, diagnosis, and therapeutic decision-making. [...]
2022 - 10.1002/alz.12372
Alzheimer's & Dementia, Vol. 18 Núm. 1 (january 2022) , p. 159-177
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12 p, 312.7 KB |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease : An international overview
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Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Arisi, Ivan (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ;
Amar, Elodie Bouaziz (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Beaume, Anne (CHU Poitiers) ;
Bedel, Aurelie (CHU Bordeaux) ;
Bellomo, Giovanni (University of Perugia) ;
Bigot-Corbel, Edith (CHU de Nantes) ;
Bjerke, Maria (University of Antwerp) ;
Blanc-Quintin, Marie-Céline (APHP Centre-Université de Paris, Cochin Hospital) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
Bousiges, Olivier (Hôpitaux Universitaires de Strasbourg) ;
Chapman, Miles D (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ;
DeMarco, Mari L. (University of British Columbia) ;
D'Onofrio, Mara (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ;
Dumurgier, Julien (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Dufour-Rainfray, Diane (CHU Tours) ;
Engelborghs, Sebastiaan (Center for Neurosciences and Department of Neurology) ;
Esselmann, Hermann (University Medical Center Goettingen (UMG) ;
Fogli, Anne (CHU Clermont-Ferrand) ;
Gabelle, Audrey (INSERM) ;
Galloni, Elisabetta (Dipartimento di Neuroscienze Divisione di Neurologia) ;
Gondolf, Clémentine (CHU Cote de Nacre Caen) ;
Grandhomme, Frédérique (CHU Cote de Nacre Caen) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hart, Melanie (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ;
Ikeuchi, Takeshi (Niigata University) ;
Jeromin, Andreas (Cohen Veterans Bioscience) ;
Kasuga, Kensaku (Niigata University) ;
Keshavan, Ashvini (UCL Institute of Neurology (Regne Unit)) ;
Khalil, Michael (Medical University of Graz) ;
Körtvelyessy, Peter (German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité-Universitäts medizin Berlin) ;
Kulczynska-Przybik, Agnieszka (Medical University of Bialystok) ;
Laplanche, Jean-Louis (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Lewczuk, Piotr (Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Li, Qiao-Xin (Florey Institute and The University of Melbourne) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Malaplate, Catherine (Biologie Moléculaire et Nutrition/ Université de Lorraine) ;
Marquié, Marta (Instituto de Salud Carlos III) ;
Masters, Colin L. (Florey Institute and The University of Melbourne) ;
Mroczko, Barbara (Medical University of Bialystok) ;
Nogueira, Léonor (CHU PURPAN) ;
Orellana, Adelina (Instituto de Salud Carlos III) ;
Otto, Markus (University of Ulm) ;
Oudart, Jean-Baptiste (Université de Reims Champagne-Ardenne) ;
Paquet, Claire (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Paoletti, Federico Paolini (University of Perugia) ;
Parnetti, Lucilla (University of Perugia) ;
Perret-Liaudet, Armand (Lyon University Hospital) ;
Peoc'h, Katell (Université de Paris GHU APHP Nord Beaujon Hospital) ;
Poesen, Koen (Leuven Brain Institute) ;
Puig-Pijoan, Albert (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Quadrio, Isabelle (Lyon University Hospital) ;
Quillard-Muraine, Muriel (Normandie Univ) ;
Rucheton, Benoit (AP-HP Sorbonne University) ;
Schraen, Susanna (Université de Lille) ;
Schott, Jonathan M. (UCL Institute of Neurology (Regne Unit)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Tumani, Hayrettin (University of Ulm) ;
Udeh-Momoh, Chinedu T (Imperial College London) ;
Vaudran, Lucie (Univ. Lille) ;
Verbeek, Marcel M (Radboud University Medical Center) ;
Verde, Federico ("Dino Ferrari" Center, Università degli Studi di Milano) ;
Vermunt, Lisa (Vrije Universiteit Amsterdam) ;
Vogelgsang, Jonathan (Harvard Medical School) ;
Wiltfang, Jens (University of Aveiro) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Lehmann, Sylvain (Université de Montpellier) ;
Universitat Autònoma de Barcelona
The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. [...]
2021 - 10.1002/alz.12545
Alzheimer's & Dementia, Vol. 18 (december 2021) , p. 1868-1879
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13 p, 1.9 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis
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Hegen, Harald (Medical University of Innsbruck) ;
Walde, Janette (University of Innsbruck) ;
Berek, Klaus (University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center (Israel)) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Clínica Mayo) ;
Teunissen, Charlotte E (Vrije Universiteit) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Clínica Mayo) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian ;
Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181
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