Dipòsit Digital de Documents de la UAB 41 registres trobats  1 - 10següentfinal  anar al registre: La cerca s'ha fet en 0.03 segons. 
1.
14 p, 7.4 MB Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors / Llinàs-Arias, Pere (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa)) ; Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ; Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ; Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ; Matsuba, Chikako (University of Southern California, Los Angeles, USA) ; Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ; Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ; Unzueta, Fernando (Universitat de Barcelona) ; Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ; Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ; Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ; Cortés, Javier (Universidad Europea de Madrid) ; DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lupien, Mathieu (University of Toronto) ; Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - 10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)  
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16 p, 3.4 MB Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution / Tomás Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; López-Martí, Paula (Barcelona Supercomputing Center) ; Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ; Ghevaert, Cedric (NHS Blood and Transplant) ; Cuatrecasas, Esther (Hospital Sant Joan de Déu) ; Costa, Dolors (Cancer Network Biomedical Research Center) ; Camós, Mireia (Instituto Carlos III) ; Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ; Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ; Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268  
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6 p, 909.0 KB The consequences of cohesin mutations in myeloid malignancies / Bhattacharya, Shubhra Ashish (Universitat Autònoma de Barcelona) ; Dias, Eve (Universitat Autònoma de Barcelona) ; Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. [...]
2023 - 10.3389/fmolb.2023.1319804
Frontiers in Molecular Biosciences, Vol. 10 (2023) , p. 1319804  
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6 p, 909.0 KB Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells / Siqueira, E (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Kim, Bo-Hyun (Department of Biochemistry and Microbiology. University of Victoria) ; Reser, Larry (Department of Chemistry. University of Virginia) ; Chow, Robert (Department of Biology. University of Victoria) ; Delaney, Kerry (Department of Biology. University of Victoria) ; Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ; Ross, Mark M. (Department of Chemistry. University of Virginia) ; Shabanowitz, Jeffrey (Department of Chemistry. University of Virginia) ; Hunt, Donald F. (Department of Pathology. University of Virginia) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ausiö, Juan (Department of Biochemistry and Microbiology. University of Victoria)
An immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions undergone during differentiation, with special emphasis on linker histones. [...]
2023 - 10.1080/15592294.2023.2276425
Epigenetics, Vol. 18 Núm. 1 (2023) , p. 2276425  
5.
33 p, 8.1 MB CEBPA phase separation links transcriptional activity and 3D chromatin hubs / Christou-Kent, Marie (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Cuartero, Sergi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Garcia-Cabau, Carla (Institute for Research in Biomedicine (IRB Barcelona)) ; Ruehle, Julia (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Naderi, Julian (Department of Genome Regulation. Max Planck Institute for Molecular Genetics) ; Erber, Julia (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Neguembor, Maria Victoria (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Plana-Carmona, Marcos (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Alcoverro Bertran, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; de Andrés-Aguayo, Luisa (Centre de Regulació Genòmica) ; Klonizakis, Antonios (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ; Julià Vilella, Eric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lynch, Cian (Altos Labs. Cambridge Institute of Science) ; Serrano, Manuel (Altos Labs. Cambridge Institute of Science) ; Hnisz, Denes (Department of Genome Regulation. Max Planck Institute for Molecular Genetics) ; Salvatella, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Graf, Thomas (Universitat Pompeu Fabra) ; Stik, Grégoire (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely understood. [...]
2023 - 10.1016/j.celrep.2023.112897
Cell reports, Vol. 42 Núm. 8 (29 2023) , p. 112897  
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29 p, 18.3 MB The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A / Mandemaker, Imke K. (Hubrecht Institute) ; Fessler, Evelyn (Gene Center and Department of Biochemistry. LMU Munich) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Kotthoff, Christiane (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ; Wegerer, Andreas (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ; Rouillon, Clément (Hubrecht Institute) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Jae, Lucas T. (Gene Center and Department of Biochemistry. LMU Munich) ; Mattiroli, Francesca (Hubrecht Institute) ; Ladurner, A.G. (Eisbach Bio GmbH)
All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish a barrier for cellular reprogramming. [...]
2023 - 10.1016/j.celrep.2023.113300
Cell reports, Vol. 42 Núm. 10 (31 2023) , p. 113300  
7.
25 p, 8.1 MB Micrococcal nuclease sequencing of porcine sperm suggests enriched co-location between retained histones and genomic regions related to semen quality and early embryo development / Gòdia, Marta (Centre de Recerca en Agrigenòmica) ; Lian, Yu (Centre de Recerca en Agrigenòmica) ; Naval-Sanchez, Marina (CSIRO. Agriculture and Food) ; Ponte Marull, Immaculada (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Clop, Alex (Centre de Recerca en Agrigenòmica)
The mammalian spermatozoon has a unique chromatin structure in which the majority of histones are replaced by protamines during spermatogenesis and a small fraction of nucleosomes are retained at specific locations of the genome. [...]
2023 - 10.7717/peerj.15520
PeerJ, Vol. 11 (june 2023)  
8.
25 p, 701.9 KB Mechanisms of epigenetic regulation of transcription by lncRNAs in plants / Tremblay, Benjamin Jean-Marie (Centre de Recerca en Agrigenòmica) ; Qüesta, Julia I. (Centre de Recerca en Agrigenòmica)
Long noncoding RNAs (lncRNAs) are an ubiquitous feature of eukaryotic genomes and in recent decades have been shown to be highly abundant and varied. Many prominent examples have been described as having essential roles in regulating the expression of genes in different developmental and environmental contexts. [...]
2023 - 10.1002/iub.2681
IUBMB Life, Vol. 75, Issue 5 (May 2023) , p. 427-439  
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27 p, 1.4 MB Epigenetics in a spectrum of myeloid diseases and its exploitation for therapy / Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mutations in genes encoding chromatin regulators are early events contributing to de-veloping asymptomatic clonal hematopoiesis of indeterminate potential and its frequent progression to myeloid diseases with increasing severity. [...]
2021 - 10.3390/cancers13071746
Cancers, Vol. 13 Núm. 7 (january 2021) , art. 1746  
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15 p, 3.4 MB Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome / Garcia, Patricia (Universidad de Salamanca) ; Fernández Hernández, Rita (Institut d'Investigació Biomèdica de Bellvitge) ; Cuadrado, Ana (Centro Nacional de Investigaciones Oncológicas) ; Coca, Ignacio (Genomics Laboratory (Barcelona)) ; Gómez, Antonio (Parc Científic de Barcelona) ; Maqueda, Maria (Institut d'Investigació Biomèdica de Bellvitge) ; Latorre Pellicer, Ana (Universidad de Zaragoza) ; Puisac, Beatriz (Universidad de Zaragoza) ; Ramos, Feliciano J. (Universidad de Zaragoza) ; Sandoval, Juan (Instituto de Investigación Sanitaria La Fe) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mosquera, José Luis (Institut d'Investigació Biomèdica de Bellvitge) ; Rodríguez, Jairo (Genomics Laboratory (Barcelona)) ; Pié, J. (Universidad de Zaragoza) ; Losada, Ana (Centro Nacional de Investigaciones Oncológicas) ; Queralt, Ethel (Instituto de Biomedicina de Valencia (IBV-CSIC)) ; Universitat Autònoma de Barcelona
Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described and are the most frequent in clinically diagnosed CdLS patients. [...]
2021 - 10.1038/s41467-021-24808-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 4551  

Dipòsit Digital de Documents de la UAB : 41 registres trobats   1 - 10següentfinal  anar al registre:
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