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16 p, 1.0 MB |
Pomalidomide, Bortezomib, and Dexamethasone in Lenalidomide-Pretreated Multiple Myeloma : A Subanalysis of OPTIMISMM by Frailty and Bortezomib Dose Adjustment
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Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Dimopoulos, Meletios (National and Kapodistrian University) ;
Schjesvold, Fredrik (University of Oslo) ;
Beksac, Meral (Ankara Üniversitesi Tip Fakültes) ;
Facon, Thierry (Hôpital Claude Huriez CHU de Lille) ;
Dhanasiri, Sujith (Celgene International Sàrl. a Bristol-Myers Squibb Company (Suïssa)) ;
Guo, Shien (Evidera) ;
Mu, Yutian (Evidera) ;
Hong, Kevin (Bristol Myers Squibb) ;
Gentili, Christian (Bristol Myers Squibb) ;
Galli, Mónica (ASST Papa Giovanni XXIII) ;
Yagci, Munci (Gazi University) ;
Larocca, Alessandra (University of Torino) ;
Richardson, Paul (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Weisel, Katja (University Medical Center Hamburg-Eppendorf (Alemanya))
Introduction: A proportion of patients with multiple myeloma (MM) are older and/or have comorbidities, requiring dose adjustments. Data from OPTIMISMM (NCT01734928) supported the use of pomalidomide, bortezomib, and dexamethasone (PVd) for treating relapsed/refractory MM. [...]
2023 -  10.1016/j.clml.2023.10.009
Clinical Lymphoma, Myeloma & Leukemia, 2023
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34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
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Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
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14 p, 1.2 MB |
Is a motivational interviewing based lifestyle intervention for obese pregnant women across Europe implemented as planned? Process evaluation of the DALI study
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Jelsma, Judith G. M. (VU University Medical Centre) ;
Simmons, David (Macarthur Clinical School) ;
Gobat, Nina (Cardiff University) ;
Rollnick, Stephen (Cardiff University) ;
Blumska, Kinga (Poznan University of Medical Sciences) ;
Jans, Goele (University Hospitals Leuven (Bèlgica)) ;
Galjaard, Sander (University Medical Centre Rotterdam) ;
Desoye, Gernot (Medizinische Universität Graz) ;
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Juarez, Fabiola (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Kautzky-Willer, Alexandra (Medical University of Vienna) ;
Harreiter, Jürgen (Medical University of Vienna) ;
van Assche, Andre (University Hospitals Leuven (Bèlgica)) ;
Devlieger, Roland (University Hospitals Leuven (Bèlgica)) ;
Timmerman, Dirk (University Hospitals Leuven (Bèlgica)) ;
Hill, David (Recherche en Santé Lawson SA) ;
Damm, Peter (University of Copenhagen) ;
Mathiesen, Elisabeth R. (University of Copenhagen) ;
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences) ;
Zawiejska, Agnieszka (Poznan University of Medical Sciences) ;
Lapolla, Annunziata (Universita Degli Studi di Padova) ;
Dalfrà, Maria G. (Universita Degli Studi di Padova) ;
del Prato, Stefano (Università di Pisa) ;
Bertolotto, Alessandra (Università di Pisa) ;
Dunne, Fidelma (National University of Ireland) ;
Jensen, Dorte M. (Odense University Hospital (Dinamarca)) ;
Andersen, Lise-Lotte (Odense University Hospital (Dinamarca)) ;
Snoek, Frank J. (Academic Medical Centre) ;
van Poppel, Mireille N. M. (University of Graz) ;
Universitat Autònoma de Barcelona
Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of gestational diabetes mellitus among European obese pregnant women with a body mass index ≥29kg/m. [...]
2017 - 10.1186/s12884-017-1471-9
BMC Pregnancy and Childbirth, Vol. 17 Núm. 1 (july 2017) , p. 293
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9 p, 406.9 KB |
Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
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Saad, Ayman (The Ohio State University) ;
Lamb, Lawrence (University of Alabama at Birmingham) ;
Wang, Tao (Medical College of Wisconsin) ;
Hemmer, Michael T. (Medical College of Wisconsin) ;
Spellman, Stephen (National Marrow Donor Program/Be the Match) ;
Couriel, Daniel R (Utah Blood and Marrow Transplant Program) ;
Alousi, Amin (Anderson Cancer Center) ;
Pidala, Joseph (H. Lee Moffitt Cancer Center) ;
Abdel-Azim, Hisham (University of Southern California Keck School of Medicine) ;
Agrawal, Vaibhav (Indiana University School of Medicine) ;
Aljurf, Mahmoud (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ;
Beitinjaneh, Amer (University of Miami) ;
Bhatt, Vijaya Raj (University of Nebraska Medical Center) ;
Buchbinder, David Kyle (Children's Hospital of Orange County) ;
Byrne, Michael (Vanderbilt University Medical Center) ;
Cahn, Jean-Yves (CHU Grenoble Alpes) ;
Cairo, Mitchell S. (New York Medical College) ;
Castillo, Paul A. (UF Health Shands Children's Hospital) ;
Chhabra, Saurabh (Medical College of Wisconsin) ;
Diaz, Miguel Angel (Hospital Infantil Universitario Nino Jesus) ;
Farhan, Shatha (Henry Ford Hospital Bone Marrow Transplant Program) ;
Floisand, Yngvar (The National Hospital) ;
Frangoul, Haydar A. (Children's Hospital at TriStar Centennial and Sarah Cannon Research Institute) ;
Gadalla, Shahinaz M. (National Cancer Institute) ;
Gajewski, James (Consultant at Lu Daopei Hospital) ;
Gale, Robert Peter (Imperial College London) ;
Gandhi, Manish (Mayo Clinic) ;
Gergis, Usama (New York Presbyterian Hospital/Weill Cornell Medical Center) ;
Hamilton, Betty (Cleveland Clinic Taussig Cancer Institute) ;
Hematti, Peiman (University of Wisconsin Hospital and Clinics) ;
Hildebrandt, Gerhard C. (University of Kentucky) ;
Kamble, Rammurti T. (Baylor College of Medicine) ;
Kanate, Abraham S. (West Virginia University) ;
Khandelwal, Pooja (Cincinnati Children's Hospital Medical Center) ;
Lazaryn, Aleksandr (H. Lee Moffitt Cancer Center) ;
MacMillan, Margaret (University of Minnesota Blood and Marrow Transplant Program) ;
Marks, David I. (University Hospitals Bristol NHS Trust) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Mehta, Parinda A. (Cincinnati Children's Hospital Medical Center) ;
Nishihori, Taiga (H. Lee Moffitt Cancer Center) ;
Olsson, Richard (Uppsala University) ;
Patel, Sagar (Cleveland Clinic Foundation) ;
Qayed, Muna (Emory University School of Medicine) ;
Rangarajan, Hemalatha G. (Nationwide Children's Hospital) ;
Reshef, R. (Columbia University Medical Center) ;
Ringden, O. (Karolinska Institutet (Estocolm, Suècia)) ;
Savani, B.N. (Vanderbilt University Medical Center) ;
Schouten, H.C. (Academische Ziekenhuis) ;
Schultz, K.R. (The University of British Columbia) ;
Seo, S. (Dokkyo Medical University) ;
Shaffer, B.C. (Memorial Sloan Kettering Cancer Center) ;
Solh, M. (Northside Hospital) ;
Teshima, T. (Hokkaido University Hospital) ;
Urbano-Ispizua, Alvaro (Hospital Clínic i Provincial de Barcelona) ;
Verdonck, L.F. (Isala Clinic) ;
Vij, R. (Washington University School of Medicine) ;
Waller, E.K. (Emory University) ;
William, B. (The Ohio State University) ;
Wirk, B. (Seattle Cancer Care Alliance) ;
Yared, J.A. (University of Maryland) ;
Yu, L.C. (Children's Hospital/Louisiana State University Medical Center) ;
Arora, M. (University of Minnesota Medical Center) ;
Hashmi, S. (Mayo Clinic) ;
Universitat Autònoma de Barcelona
Data on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transplantation for acute leukemia or myelodysplastic syndrome between 2008 and 2014 using an HLA-matched sibling donor (MSD) or an 8/8-matched unrelated donor (MUD). [...]
2019 - 10.1016/j.bbmt.2019.05.007
Biology of blood and marrow transplantation, Vol. 25 Núm. 9 (september 2019) , p. 1875-1883
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24 p, 1.1 MB |
Highlights from the 2019 International Aspirin Foundation Scientific Conference, Rome, 28 June 2019 : Benefits and risks of antithrombotic therapy for cardiovascular disease prevention
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Walker, Jaqui (International Aspirin Foundation) ;
Cattaneo, Marco (Università degli studi di Milano) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Agnelli, Giancarlo (University of Perugia) ;
Chan, Andrew T. (Harvard Medical School) ;
Lanas, Angel (Universidad de Zaragoza) ;
Rocca, Bianca (Catholic University School of Medicine) ;
Rothwell, Peter (Centre for the Prevention of Stroke and Dementia) ;
Patrignani, Paola ('G.d'Annunizio' University) ;
Langley, Ruth (MRC Clinical Trials Unit at UCL) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Cosentino, Francesco (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Universitat Autònoma de Barcelona
At the 2019 International Aspirin Foundation Scientific Conference 'Benefits and Risks of Antithrombotic Therapy for Cardiovascular Disease Prevention', held in Rome, Italy, international experts sought to discuss and debate the optimal antithrombotic strategy for the secondary prevention of cardiovascular disease (CVD) and to seek agreement around dosing and target populations for aspirin use in primary disease prevention. [...]
2020 - 10.3332/ECANCER.2019.998
ecancermedicalscience, Vol. 14 (13 2020) , p. 998
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8 p, 359.9 KB |
What is plan quality in radiotherapy? The importance of evaluating dose metrics, complexity, and robustness of treatment plans
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Hernandez Masgrau, Victor (Hospital Sant Joan de Reus) ;
Hansen, Christian Rønn (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Widesott, Lamberto (Centro di protonterapia) ;
Bäck, Anna (Sahlgrenska Academy at the University of Gothenburg) ;
Canters, Richard (Maastricht University Medical Centre+) ;
Fusella, Marco (Veneto Institute of Oncology IOV - IRCCS) ;
Götstedt, Julia (University of Gothenburg) ;
Jurado-Bruggeman, Diego (Institut Català d'Oncologia) ;
Mukumoto, Nobutaka (Kyoto University) ;
Kaplan, Laura Patricia (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Koniarova, Irena (National Radiation Protection Institute) ;
Piotrowski, Tomasz (Greater Poland Cancer Centre) ;
Placidi, Lorenzo (Fondazione Policlinico Universitario "A. Gemelli" IRCCS) ;
Vaniqui, Ana (Maastricht University Medical Centre+) ;
Jornet, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Plan evaluation is a key step in the radiotherapy treatment workflow. Central to this step is the assessment of treatment plan quality. Hence, it is important to agree on what we mean by plan quality and to be fully aware of which parameters it depends on. [...]
2020 - 10.1016/j.radonc.2020.09.038
Radiotherapy and Oncology, Vol. 153 (december 2020) , p. 26-33
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8 p, 664.2 KB |
Exposure-response modeling of cabozantinib in patients with renal cell carcinoma : Implications for patient care
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Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Maroto Rey, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Benzaghou, Fawzi (Ipsen Pharma) ;
Taguieva, Naila (Ipsen Pharma) ;
Nguyen, Linh (Exelixis. Inc.) ;
Clary, Douglas O. (Exelixis. Inc.) ;
Jonasch, Eric W. (The University of Texas MD Anderson Cancer Center) ;
Universitat Autònoma de Barcelona
Cabozantinib is an oral tyrosine kinase inhibitor (TKI) approved for the treatment of patients with advanced renal cell carcinoma (RCC) at a dose of 60 mg/day. As with other TKIs, cabozantinib is associated with high interpatient variability in drug clearance and exposure that can significantly impact safety and tolerability across a patient population. [...]
2020 - 10.1016/j.ctrv.2020.102062
Cancer Treatment Reviews, Vol. 89 (september 2020) , p. 102062
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6 p, 636.0 KB |
Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in Catalonia, Spain
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Borras, Josep M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Font, R. (Catalunya. Generalitat) ;
Solà, J. (Catalunya. Generalitat) ;
Macia, M. (Institut Català d'Oncologia) ;
Tuset, V. (Institut Català d'Oncologia) ;
Arenas, M. (Universitat Rovira i Virgili) ;
Eraso, Arantxa (Institut Català d'Oncologia) ;
Verges, R. (Hospital Universitari Vall d'Hebron) ;
Farré, Núria (Institut d'Investigació Biomèdica Sant Pau) ;
Pedro, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Mollà, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Algara, Manuel (Hospital del Mar (Barcelona, Catalunya)) ;
Solé, J.M. (Consorci Sanitari de Terrassa) ;
Mira, M. (Hospital Universitari Arnau de Vilanova) ;
Espinàs, J.A. (Catalunya. Generalitat) ;
Universitat Autònoma de Barcelona
This study aims to assess the effects of non-adherence to external beam radiation therapy in cancer patients receiving treatment with a curative. This retrospective cohort study collected health records data for all cancer patients treated with external beam radiotherapy with curative intent in 2016 in Catalonia, Spain. [...]
2020 - 10.1016/j.radonc.2020.08.002
Radiotherapy and Oncology, Vol. 151 (october 2020) , p. 200-205
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12 p, 2.3 MB |
Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia
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Rodríguez-Tomàs, Elisabet (Institut d'Investigació Sanitària Pere Virgili) ;
Acosta, Johana C. (Institut d'Investigació Sanitària Pere Virgili) ;
Torres-Royo, Laura (Institut d'Investigació Sanitària Pere Virgili) ;
De Febrer, Gabriel (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Baiges-Gaya, Gerard (Institut d'Investigació Sanitària Pere Virgili) ;
Castañé, Helena (Institut d'Investigació Sanitària Pere Virgili) ;
Jiménez, Andrea (Institut d'Investigació Sanitària Pere Virgili) ;
Vasco, Carlos (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Araguas, Pablo (Institut d'Investigació Sanitària Pere Virgili) ;
Gómez, Junior (Institut d'Investigació Sanitària Pere Virgili) ;
Malave, Bárbara (Institut d'Investigació Sanitària Pere Virgili) ;
Árquez, Miguel (Institut d'Investigació Sanitària Pere Virgili) ;
Calderón, David (Institut d'Investigació Sanitària Pere Virgili) ;
Piqué, Berta (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Algara, Manuel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montero, Ángel (Hospital Universitario HM Sanchinarro (Madrid)) ;
Simó, Josep M. (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Gabaldó-Barrios, Xavier (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Sabater, Sebastià (Complejo Hospitalario Universitario de Albacete) ;
Camps, Jordi (Institut d'Investigació Sanitària Pere Virgili) ;
Joven, Jorge (Institut d'Investigació Sanitària Pere Virgili) ;
Arenas, Meritxell (Institut d'Investigació Sanitària Pere Virgili) ;
Universitat Autònoma de Barcelona
The aim of our study was to investigate the changes produced by low-dose radiotherapy (LDRT) in the circulating levels of the antioxidant enzyme paraoxonase-1 (PON1) and inflammatory markers in patients with COVID-19 pneumonia treated with LDRT and their interactions with clinical and radiological changes. [...]
2022 - 10.3390/antiox11061184
Antioxidants, Vol. 11 (june 2022)
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