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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 -  10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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29 p, 401.7 KB |
Epigenetic targets in B- and T-cell lymphomas : latest developments
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Ribeiro, Marcelo L. (Sao Francisco University Medical School) ;
Sánchez Vinces, Salvador (Sao Francisco University Medical School) ;
Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Non-Hodgkin's lymphomas (NHLs) comprise a diverse group of diseases, either of mature B-cell or of T-cell derivation, characterized by heterogeneous molecular features and clinical manifestations. While most of the patients are responsive to standard chemotherapy, immunotherapy, radiation and/or stem cell transplantation, relapsed and/or refractory cases still have a dismal outcome. [...]
2023 - 10.1177/20406207231173485
Therapeutic Advances in Hematology, Vol. 14 (1-12 2023)
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3.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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14 p, 8.9 MB |
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection
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Bińkowski, Jan (Institució Catalana de Recerca i Estudis Avançats) ;
Taryma-Leśniak, Olga (Institució Catalana de Recerca i Estudis Avançats) ;
Łuczkowska, Karolina (Pomeranian Medical University in Szczecin, Poland) ;
Niedzwiedź, Anna (Independent Public Regional Hospital in Szczecin, Poland) ;
Lechowicz, Kacper (Pomeranian Medical University in Szczecin, Poland) ;
Strapagiel, Dominik (University of Lodz, Poland) ;
Jarczak, Justyna (University of Lodz, Poland) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Kotfis, Katarzyna (Pomeranian Medical University in Szczecin, Poland) ;
Machaliński, Boguslaw (Pomeranian Medical University in Szczecin, Poland) ;
Parczewski, Milosz (Pomeranian Medical University in Szczecin, Poland) ;
Wojdacz, Tomasz K. (Aarhus University, Denmark)
Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a potential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic lesions that stratify patients according to the severity of infection symptoms, and more importantly, the significance of those epigenetic changes in the pathology of the infection is still not clear. [...]
2022 - 10.1016/j.biopha.2022.113396
Biomedicine & pharmacotherapy, Vol. 153 (september 2022)
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7.
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22 p, 8.7 MB |
Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
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Waryah, Charlene (University of Western Australia) ;
Cursons, Joseph (Monash University, Australia) ;
Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ;
Pflueger, Christian (University of Western Australia) ;
Wang, Edina (University of Western Australia) ;
Molania, Ramyar (University of Melbourne, Australia) ;
Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ;
Sorolla, Anabel (University of Western Australia) ;
Wallis, Christopher (University of Western Australia) ;
Moses, Colette (University of Amsterdam, The Netherlands) ;
Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ;
Magalhães, Leandro (University of Pará, Brazil) ;
Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ;
Fearnley, Liam G. (University of Melbourne, Australia) ;
Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ;
Davis, Melissa (University of Melbourne, Australia) ;
Papenfuss, Anthony T. (University of Melbourne, Australia) ;
Redfern, Andrew (University of Western Australia) ;
Lister, Ryan (The University of Western Australia) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 - 10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)
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8.
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Impacte dels mecanismes epigenètics en la migranya. Identificació i validació de patrons d'expressió diferencials de microARNs en pacients amb migranya
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Gallardo López, Víctor José ;
Pozo Rosich, Patricia, dir. ;
Álvarez-Sabin, José, dir.
Diversos estudis pilot han estudiat el rol dels microARNs (miARNs) en la migranya. No obstant això, els estudis són poc comparables i reproduïbles degut a l'alt grau d'heterogeneïtat que existeix entre els grups. [...]
Varios estudios piloto han estudiado el rol de los microARNs (miARNs) en la migraña. Sin embargo, los estudios son poco comparables y reproducibles debido al alto grado de heterogeneidad que existe entre los grupos. [...]
Several studies have described the potential role of microRNA (miRNAs) in migraine but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Hence, the main objective of this project is to identify and validate differentially expressed miRNAs (DE miRNAs) in peripheral blood mononuclear cells (PBMCs) of patients with migraine compared to healthy controls (HC) in a well-controlled homogeneous cohort of participants using a three-step methodology: (a) exploratory study, (b) main study and (c) validation study. [...]
2023
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33 p, 1.2 MB |
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
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Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ;
On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528
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10 p, 2.1 MB |
Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents
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Bellver-Sanchis, Aina (Universitat de Barcelona) ;
Singh Choudhary, Bhanwar (Ganpat University) ;
Companys-Alemany, Júlia (Universitat de Barcelona) ;
Sukanya, None (Central University of Rajasthan) ;
Ávila-López, Pedro A. (Northwestern University) ;
Martínez Rodríguez, Antón Leandro (Universidade de Santiago de Compostela) ;
Brea Floriani, Jose Manuel (Universidade de Santiago de Compostela) ;
Malik, Ruchi (Central University of Rajasthan) ;
Pallàs, Mercè (Universitat de Barcelona) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Griñán-Ferré, Christian (Universitat de Barcelona)
G9a is a lysine methyltransferase able to di-methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post-translational modifications and effectively treat neurodegenerative diseases, like Alzheimer's disease (AD). [...]
2022 - 10.1002/cmdc.202200002
ChemMedChem, Vol. 17 (may 2022)
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