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1.
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24 p, 6.3 MB |
CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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Evans, Frances (Instituto Pasteur de Montevideo) ;
Alí-Ruiz, Daniela (Instituto Pasteur de Montevideo) ;
Rego, Natalia (Instituto Pasteur de Montevideo) ;
Negro-Demontel, Maria Luciana (Instituto Pasteur de Montevideo) ;
Lago, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cawen, Fabio Andrés (Instituto Pasteur de Montevideo) ;
Pannunzio, Bruno (Instituto Pasteur de Montevideo) ;
Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Reyes, Laura (Centro Uruguayo de Imagenología Molecular) ;
Paolino, Andrea (Centro Uruguayo de Imagenología Molecular) ;
Rodríguez-Duarte, Jorge (Instituto Pasteur de Montevideo) ;
Pérez-Torrado, Valentina (Instituto Pasteur de Montevideo) ;
Chicote-González, Almudena (Universitat de Barcelona. Departament de Biomedicina) ;
Quijano, Celia (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Marmisolle, Inés (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Mulet, Ana Paula (Instituto Pasteur de Montevideo) ;
Schlapp, Geraldine (Instituto Pasteur de Montevideo) ;
Meikle, Maria Noel (Instituto Pasteur de Montevideo) ;
Bresque, Mariana (Instituto Pasteur de Montevideo) ;
Crispo, Martina (Instituto Pasteur de Montevideo) ;
Savio, Eduardo (Centro Uruguayo de Imagenología Molecular) ;
Malagelada, Cristina (Universitat de Barcelona. Departament de Biomedicina) ;
Escande, Carlos (Instituto Pasteur de Montevideo) ;
Peluffo, Hugo (Instituto Pasteur de Montevideo) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. [...]
2023 -  10.1016/j.celrep.2023.113269
Cell reports, Vol. 42 Núm. 10 (2023) , p. 113269
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2.
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44 p, 10.1 MB |
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
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Mielczarek, O. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Rogers, C.H. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Zhan, Y. (Friedrich Miescher Institute for Biomedical Research) ;
Matheson, L.S. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Stubbington, M.J.T. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Schoenfelder, S. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Bolland, D.J. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wingett, S.W. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Várnai, C. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Segonds-Pichon, A. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Conn, S.J. (Flinders Health and Medical Research Institute. College of Medicine and Public Health. Flinders University) ;
Krueger, F. (Babraham Institute) ;
Andrews, S. (Babraham Institute) ;
Fraser, Peter (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Giorgetti, L. (Friedrich Miescher Institute for Biomedical Research) ;
Corcoran, A.E. (Immunology Programme. Babraham Institute. Babraham Research Campus)
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J) genes. [...]
2023 - 10.1016/j.celrep.2023.113074
Cell reports, Vol. 42 Núm. 9 (26 2023) , p. 113074
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3.
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28 p, 8.7 MB |
Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
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Garcia-Diaz, Claudia (Samantha Dickson Brain Cancer Unit) ;
Pöysti, Anni (Samantha Dickson Brain Cancer Unit) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Clements, Melani P. (Samantha Dickson Brain Cancer Unit) ;
Brooks, Lucy J. (Samantha Dickson Brain Cancer Unit. UCL Cancer Institute) ;
Galvez-Cancino, Felipe (Cancer Immunology Unit. Research Department of Haematology) ;
Castillo, Simon P. (The Institute of Cancer Research) ;
Tang, Wenhao T. (Department of Mathematics. Imperial College London) ;
Beattie, Gordo (University College London) ;
Courtot, Lilas (Samantha Dickson Brain Cancer Unit) ;
Ruiz, Sara (Barcelona Institute of Science and Technology (BIST)) ;
Roncaroli, Federico (University of Manchester) ;
Yuan, Yinyin (The Institute of Cancer Research) ;
Marguerat, Samuel (University College London) ;
Quezada, Sergio A. (UCL Cancer Institute) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Parrinello, Simona (UCL Cancer Institute)
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse models, driven by subtype-associated mutations, to compare matched bulk and margin cells. [...]
2023 - 10.1016/j.celrep.2023.112472
Cell reports, Vol. 42 Núm. 5 (30 2023) , p. 112472
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4.
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23 p, 7.0 MB |
MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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Alburquerque-Béjar, Juan Jos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Navajas-Chocarro, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Saigi, Maria (Department of Medical Oncology. Catalan Institute of Oncology (ICO)) ;
Ferrero-Andres, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morillas, Juan M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vilarrubi, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ;
Mate, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Munoz-Marmol, Ana M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero, Octavio A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pros, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llabata, Paula (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torres-Diz, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. [...]
2023 - 10.1016/j.xcrm.2023.101006
Cell Reports Medicine, Vol. 4 Núm. 4 (april 2023)
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5.
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33 p, 8.1 MB |
CEBPA phase separation links transcriptional activity and 3D chromatin hubs
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Christou-Kent, Marie (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Cuartero, Sergi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Cabau, Carla (Institute for Research in Biomedicine (IRB Barcelona)) ;
Ruehle, Julia (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Naderi, Julian (Department of Genome Regulation. Max Planck Institute for Molecular Genetics) ;
Erber, Julia (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Neguembor, Maria Victoria (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Plana-Carmona, Marcos (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Alcoverro Bertran, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de Andrés-Aguayo, Luisa (Centre de Regulació Genòmica) ;
Klonizakis, Antonios (Centre for Genomic Regulation (CRG). The Barcelona Institute of Science and Technology) ;
Julià Vilella, Eric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lynch, Cian (Altos Labs. Cambridge Institute of Science) ;
Serrano, Manuel (Altos Labs. Cambridge Institute of Science) ;
Hnisz, Denes (Department of Genome Regulation. Max Planck Institute for Molecular Genetics) ;
Salvatella, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Graf, Thomas (Universitat Pompeu Fabra) ;
Stik, Grégoire (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely understood. [...]
2023 - 10.1016/j.celrep.2023.112897
Cell reports, Vol. 42 Núm. 8 (29 2023) , p. 112897
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6.
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29 p, 18.3 MB |
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
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Mandemaker, Imke K. (Hubrecht Institute) ;
Fessler, Evelyn (Gene Center and Department of Biochemistry. LMU Munich) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Kotthoff, Christiane (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Wegerer, Andreas (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Rouillon, Clément (Hubrecht Institute) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jae, Lucas T. (Gene Center and Department of Biochemistry. LMU Munich) ;
Mattiroli, Francesca (Hubrecht Institute) ;
Ladurner, A.G. (Eisbach Bio GmbH)
All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish a barrier for cellular reprogramming. [...]
2023 - 10.1016/j.celrep.2023.113300
Cell reports, Vol. 42 Núm. 10 (31 2023) , p. 113300
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7.
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17 p, 4.1 MB |
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
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Hurtado-Navarro, Laura (Instituto Murciano de Investigación Biosanitaria) ;
Cuenca-Zamora, Ernesto José (Instituto Murciano de Investigación Biosanitaria) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Such, Esperanza (Hospital Universitari i Politècnic La Fe (València)) ;
Soler-Espejo, Eva (Hospital Universitario Morales-Meseguer, Centro Regional de Hemodonación, Murcia) ;
Martínez-Banaclocha, Helios (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Hernández-Rivas, Jesús Maria (Universidad de Salamanca) ;
Marco-Ayala, Javier (Hospital Universitario Morales-Meseguer. Murcia) ;
Martínez-Alarcón, Laura (Instituto Murciano de Investigación Biosanitaria) ;
Linares-Latorre, Lola (Fundació Institut Valencià d'Oncologia) ;
García-Ávila, Sara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Amat-Martínez, Paula (Hospital Clínic Universitari (València). Health Research Institute) ;
González, Teresa (Universidad de Salamanca) ;
Arnan, Montserrat (Institut Català D'Oncologia (ICO)-Hospital Duran I Reynals. IDIBELL) ;
Pomares-Marín, Helena (Institut Català D'Oncologia (ICO)-Hospital Duran I Reynals. IDIBELL) ;
Carreño-Tarragona, Gonzalo (Hospital 12 de Octubre (Madrid)) ;
Chen-Liang, Tzu Hua (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Herranz, María T. (Hospital Universitario Morales Meseguer) ;
García-Palenciano, Carlos (Hospital Clínico Universitario Virgen de La Arrixaca) ;
Morales, María Luz (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Jerez, Andrés (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Lozano, María L. (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Teruel-Montoya, Raúl (Universidad Católica San Antonio (UCAM)) ;
Pelegrín, Pablo (University of Murcia) ;
Ferrer-Marín, Francisca (Universidad Católica San Antonio (UCAM))
Chronic myelomonocytic leukemia (CMML) is frequently associated with mutations in the rat sarcoma gene (RAS), leading to worse prognosis. RAS mutations result in active RAS-GTP proteins, favoring myeloid cell proliferation and survival and inducing the NLRP3 inflammasome together with the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which promote caspase-1 activation and interleukin (IL)-1β release. [...]
2023 - 10.1016/j.xcrm.2023.101329
Cell Reports Medicine, Vol. 4 Núm. 12 (december 2023)
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8.
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25 p, 6.3 MB |
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Arias-Sardá, Cristina (University of Kent. School of Biosciences) ;
Montes-Espuña, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lister, Nicholas C. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Cuartero, Yasmina (Centre de Regulació Genòmica) ;
García, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Deakin, Janine (University of Canberra. Institute for Applied Ecology) ;
Renfree, Marilyn B. (The University of Melbourne. School of Biosciences) ;
Robinson, Terence J. (Stellenbosch University. Department of Botany and Zoology) ;
Martí-Renom, Marc A. (Centre de Regulació Genòmica) ;
Waters, Paul D. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Farré, Marta (University of Kent. School of Biosciences) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. [...]
2022 - 10.1016/j.celrep.2022.111839
Cell reports, Vol. 41, Issue 12 (December 2022) , art. 111839
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9.
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19 p, 4.3 MB |
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses
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Martos-Folgado, Inmaculada (Medical Department. Pfizer S.L.U.) ;
del Monte-Monge, Alberto (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Lorenzo, Cristina (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Busse, Christian E. (Division of B Cell Immunology. German Cancer Research Center) ;
Delgado, Pilar (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Mur, Sonia M. (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Cobos-Figueroa, Laura (Grupo de Manufactura Avanzada con Láser del Centro Láser. Universidad Politécnica de Madrid) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Martín-Ventura, Jose L. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Wardemann, Hedda (Division of B Cell Immunology. German Cancer Research Center) ;
Ramiro, Almudena R. (Lymphocyte Biology Lab. Centro Nacional de Investigaciones Cardiovasculares (CNIC))
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. [...]
2022 - 10.1016/j.celrep.2022.111468
Cell reports, Vol. 41 Núm. 2 (november 2022) , p. 111468
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10.
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24 p, 6.5 MB |
Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis
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Cid, Elena (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Marquez-Galera, A. (Instituto de Neurociencias. Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC)) ;
Valero, Manuel (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Gal, B. (Universidad Europea de Madrid) ;
Medeiros, D.C. (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Navarron, C.M. (Instituto de Neurociencias. Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC)) ;
Ballesteros-Esteban, L. (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Reig-Viader, R. (Universitat Autònoma de Barcelona) ;
Morales, Aixa V. (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Fernandez-Lamo, I. (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Gomez-Dominguez, D. (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Sato, M. (RIKEN Brain Science Institute) ;
Hayashi, Y. (Kyoto University Graduate School of Medicine) ;
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau) ;
Barco, Ángel (Instituto de Neurociencias. Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC)) ;
Lopez-Atalaya, J.P. (Instituto de Neurociencias. Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC)) ;
de la Prida, Liset Menéndez (Instituto Cajal (Consejo Superior de Investigaciones Científicas))
Hippocampal sclerosis, the major neuropathological hallmark of temporal lobe epilepsy, is characterized by different patterns of neuronal loss. The mechanisms of cell-type-specific vulnerability and their progression and histopathological classification remain controversial. [...]
2021 - 10.1016/j.celrep.2021.109229
Cell reports, Vol. 35 Núm. 10 (august 2021) , p. 109229
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