Dipòsit Digital de Documents de la UAB 13 registres trobats  1 - 10següent  anar al registre: La cerca s'ha fet en 0.01 segons. 
1.
52 p, 1.9 MB Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase / Crespo, Isidro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Giménez-Dejoz, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Porté, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cousido-Siah, Alexandra (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Mitschler, André (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Podjarny, Alberto (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Pratsinis, Harris (Institute of Biosciences and Applications, National Centre of Scientific Research "Demokritos", Athens, Greece) ; Kletsas, Dimitris (Institute of Biosciences and Applications, National Centre of Scientific Research "Demokritos", Athens, Greece) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ruiz, Francesc Xavier (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Metwally, Kamel (Zagazig University, Egypt) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes secondary complications and, in some cases, with cancer. [...]
2018 - 10.1016/j.ejmech.2018.04.015
European Journal of Medicinal Chemistry, Vol. 152 (2018) , p. 160-174  
2.
10 p, 5.6 MB PITB : A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties / Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Varejão, Nathalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez-Morales, Adrià (Universitat Autònoma de Barcelona. Departament de Química) ; Bezerra, Filipa (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Velázquez-Campoy, Adrian (Universidad de Zaragoza) ; Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ; Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The aggregation of wild-type transthyretin (TTR) and over 130 genetic TTR variants underlies a group of lethal disorders named TTR amyloidosis (ATTR). TTR chemical chaperones are molecules that hold great promise to modify the course of ATTR progression. [...]
2023 - 10.1016/j.ejmech.2023.115837
European Journal of Medicinal Chemistry, Vol. 261 (may 2023) , p. 115837  
3.
16 p, 1.0 MB Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria / Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Horgan, Conor (University College Cork) ; Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; O'Driscoll, Michelle (University College Cork) ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; O'Sullivan, Timothy (University College Cork)
The diffusible signal factor family (DSF) of molecules play an important role in regulating intercellular communication, or quorum sensing, in several disease-causing bacteria. These messenger molecules, which are comprised of cis-unsaturated fatty acids, are involved in the regulation of biofilm formation, antibiotic tolerance, virulence and the control of bacterial resistance. [...]
2023 - 10.1016/j.ejmech.2023.115819
European Journal of Medicinal Chemistry, Vol. 261 (December 2023) , art. 115819  
4.
16 p, 1.1 MB Synthesis, antiviral evaluation, and computational studies of cyclobutane and cyclobutene L-nucleoside analogues / Miralles Llumà, Rosa (Universitat Autònoma de Barcelona. Departament de Química) ; Figueras, Antoni (Universitat Autònoma de Barcelona. Departament de Química) ; Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ; Alvarez-Larena, Angel (Universitat Autònoma de Barcelona. Servei de Difracció de Raigs X) ; Balzarini, Jan (KU Leuven. Rega Institute for Medical Research) ; Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química) ; Font i Cierco, Josep (Universitat Autònoma de Barcelona. Departament de Química) ; Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química) ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química)
This paper describes the stereoselective synthesis of a series of functionalized cyclobutane and cyclobutene L-nucleoside analogues featuring a methylene spacer between the carbocycle and the nucleobase. [...]
2013 - 10.1002/ejoc.201301097
European journal of organic chemistry, Vol. 2013, issue 34 (Dec. 2013) , p. 7761-7775  
5.
9 p, 861.1 KB Filling some blanks in a divergent approach to gabosines : enantioselective synthesis of (-)-epiepoxydon, (+)-phyllostine, (-)-gabosine D, and (-)-gabosine E / Fresneda, Miguel Ángel (Universitat Autònoma de Barcelona. Departament de Química) ; Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química) ; Bayón, Joan Carles (Universitat Autònoma de Barcelona. Departament de Química) ; Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química)
The levorotatory enantiomers of gabosines D and E were synthesized through a divergent approach that could equally well be applied to the synthesis of the dextrorotatory enantiomers, which have been isolated from natural sources. [...]
2016 - 10.1002/ejoc.201600492
European journal of organic chemistry, Vol. 2016, issue 21 (July 2016) , p. 3568-3574  
6.
16 p, 7.0 MB Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens / Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Lyons, Thérèse (University College Cork. School of Pharmacy) ; Mamat, Uwe (Leibniz Lung Center. Cellular Microbiology) ; Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Elshafee, Osama (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ; Brunke, Sascha (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ; Gahan, Cormac G.M. (University College Cork. APC Microbiome Ireland) ; O'Driscoll, Michelle (University College Cork. Analytical and Biological Chemistry Research Facility) ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; O'Sullivan, Timothy P. (University College Cork. Analytical and Biological Chemistry Research Facility)
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. [...]
2022 - 10.1016/j.ejmech.2022.114678
European Journal of Medicinal Chemistry, Vol. 242 (November 2022) , art. 114678  
7.
19 p, 6.6 MB Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer / Sánchez-Morales, Adrià (Universitat Autònoma de Barcelona. Departament de Química) ; Biçer, Atilla (Institut d'Investigació Biomèdica de Bellvitge) ; Panagiotopoulos, Vasilis (University of West Attica. Department of Biomedical Engineering) ; Crecente-Garcia, Selma (Universitat Autònoma de Barcelona. Departament de Química) ; Benaiges Miñarro, Cristina (Universitat Autònoma de Barcelona. Departament de Química) ; Bayod, Sergi (Parc Científic de Barcelona) ; Hernández, José Luís (Parc Científic de Barcelona) ; Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ; Matsoukas, Minos-Timotheos (University of West Attica. Department of Biomedical Engineering) ; Pérez-Riba, Mercè (Institut d'Investigació Biomèdica de Bellvitge) ; Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química)
The Ca2/calmodulin-mediated phosphatase activity of calcineurin (CN) integrates calcium-mediated signaling with gene expression programs involved in the control of essential cellular processes in health and disease, such as the immune response and the pathogenesis of cancer progression and metastasis. [...]
2022 - 10.1016/j.ejmech.2022.114514
European Journal of Medicinal Chemistry, Vol. 238 (August 2022) , art. 114514  
8.
6 p, 2.6 MB Synthesis of Chiral Scaffolds Based on Polyfunctional Cyclobutane β-Amino Acids / Verkh, Yaroslav (Universitat Autònoma de Barcelona. Departament de Química) ; Illa, Ona (Universitat Autònoma de Barcelona. Departament de Química) ; Ortuño Mingarro, Rosa María (Universitat Autònoma de Barcelona. Departament de Química)
Chiral scaffolds have been synthesized through selective transformations from conveniently protected cyclobutane β-amino acids. The obtained derivatives present additional functional groups, such as hydroxyl, carboxyl, or carbon-carbon triple bond, linked to the amino acid core through a flexible C or C alkyl fragment. [...]
2021 - 10.1002/ejoc.202101192
European journal of organic chemistry, Vol. 2021, Issue 44 (November 2021) , p. 6022-6027  
9.
9 p, 844.2 KB Computational Organometallic Catalysis : Where We Are, Where We Are Going / Lledós, Agustí (Lledós i Falcó) (Universitat Autònoma de Barcelona. Departament de Química)
This essay gives my personal perspective of the current stage of computational methods applied to modeling organometallic catalysis, as well as the new directions the field is taking. The first part of the essay deals with what I consider the state-of-the-art to build up energy profiles, regarding both chemical and computational models. [...]
2021 - 10.1002/ejic.202100330
European journal of inorganic chemistry, Vol. 2021, Issue 26 (July 2021) , p. 2547-2555  
10.
13 p, 2.1 MB Four molecular superconductors isolated as nanoparticles / De Caro, Dominique (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Faulmann, Cristophe (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Valade, Lydie (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Jacob, Kane (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Chtioui, Imane (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Foulal, Soukaina (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; De Caro, Pascale (Université de Toulouse. Laboratoire de Chimie Agro-industrielle) ; Bergez-Lacoste, Manon (Université de Toulouse. Laboratoire de Chimie Agro-industrielle) ; Fraxedas, Jordi (Institut Català de Nanociència i Nanotecnologia) ; Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ; Brooks, James S. (Florida State University. The National High Magnetic Field Laboratory) ; Steven, Eden (Florida State University. The National High Magnetic Field Laboratory) ; Winter, Laurel E. (Florida State University. The National High Magnetic Field Laboratory)
(TMTSF)₂PF₆ and (TMTSF)₂ClO₄ Bechgaard salts, (BEDT-TTF)₂I₃, and TTF[Ni(dmit)₂]₂ [TMTSF = tetramethyltetraselenafulvalene; BEDT-TTF = bis(ethylenedithio)tetrathiafulvalene; TTF = tetrathiafulvalene; dmit = 1,3-dithiole-2-thione-4,5-dithiolate] are among the most popular molecular superconductors. [...]
2014 - 10.1002/ejic.201402007
European journal of inorganic chemistry, Vol. 2014, issue 24 (August 2014) , p. 4010-4016  

Dipòsit Digital de Documents de la UAB : 13 registres trobats   1 - 10següent  anar al registre:
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