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8 p, 192.2 KB |
Denosumab or zoledronic acid in postmenopausal women with osteoporosis previously treated with oral bisphosphonates
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Miller, P.D. (Colorado Center for Bone Research) ;
Pannacciulli, N. (Amgen Inc) ;
Brown, J.P. (Laval University) ;
Czerwinski, E. (Krakow Medical Center) ;
Nedergaard, B.S. (Center for Clinical and Basic Research) ;
Bolognese, M.A. (Bethesda Health Research Center) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Bone, H.G. (Michigan Bone and Mineral Clinic) ;
Reginster, J. Y. (University of Liège) ;
Singer, A. (Georgetown University Medical Center) ;
Wang, C. (Amgen Inc) ;
Wagman, R.B. (Amgen Inc) ;
Cummings, S.R. (California Pacific Medical Center Research Institute) ;
Universitat Autònoma de Barcelona
Denosumab and zoledronic acid (ZOL) are parenteral treatments for patients with osteoporosis. The objective of the study was to compare the effect of transitioning from oral bisphosphonates to denosumab or ZOL on bone mineral density (BMD) and bone turnover. [...]
2016 -  10.1210/jc.2016-1801
The journal of clinical endocrinology & metabolism, Vol. 101 Núm. 8 (august 2016) , p. 3163-3170
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2.
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8 p, 366.3 KB |
Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly
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Ruiz-Janer, Sabina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Venegas, Eva (Hospital Universitario Virgen del Rocío (Andalusia)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Garcia-Centeno, Rogelio (Hospital Universitario Gregorio Marañón) ;
Gálvez, María Ángeles (Hospital Universitario Reina Sofía (Andalusia)) ;
Picó Alfonso, Antonio M. (Hospital General Universitario de Alicante) ;
Maraver, Silvia (Hospital Universitario Virgen de la Victoria (Andalusia)) ;
González, Inmaculada (Hospital Regional Universitario de Málaga) ;
Abellán-Galiana, Pablo (Hospital General Universitario de Castelló) ;
Trincado, Pablo (Hospital Universitario Miguel Servet (Saragossa)) ;
Herrera, Mayte T. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Olvera, Pilar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bernabeu Morón, Ignacio (Complejo Universitario de Santiago de Compostela) ;
Serra-Soler, Guillermo (Hospital Universitari Son Espases (Illes Balears)) ;
Azriel, Sharona (Hospital Universitario Infanta Sofía (Madrid)) ;
García, Lourdes (Hospital Universitario de Jerez (Illes Canàries)) ;
Carvalho, Davide (Centro Hospitalar Universitário de São João (Portugal)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig, Josep (Hospital Universitari de Girona Doctor Josep Trueta) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objective: Hyperintensity signal in T2-weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment in acromegaly. The aim of the study was to evaluate T2 MRI signal intensity and its relation with pasireotide therapeutic effectiveness in real-life clinical practice. [...]
2023 - 10.1111/cen.14946
Clinical Endocrinology, Vol. 99 Núm. 4 (october 2023) , p. 378-385
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10 p, 393.1 KB |
Thyroid Function in 509 Premature Newborns Below 31 Weeks of Gestational Age : Evaluation and Follow-up
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Campos-Martorell, Ariadna (Hospital Universitari Vall d'Hebron) ;
Montaner Ramón, Alicia (Hospital Universitari Vall d'Hebron) ;
Narváez Barros, Karla (Hospital del Mar (Barcelona, Catalunya)) ;
Marin Soria, Jose Luis (Hospital Clínic i Provincial de Barcelona) ;
López Galera, Rosa Maria (Hospital Clínic i Provincial de Barcelona) ;
Yeste Fernández, Diego (Hospital Universitari Vall d'Hebron) ;
Clemente, Maria (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Preterm and low birth weight (LBW) neonates may present with thyroid dysfunction during a critical period for neurodevelopment. These alterations can be missed on routine congenital hypothyroidism (CH) screening which only measures thyroid stimulating hormone (TSH). [...]
2022 - 10.4274/jcrpe.galenos.2022.2022-2-1
Journal of Clinical Research in Pediatric Endocrinology, Vol. 14 (december 2022) , p. 453-462
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26 p, 1.2 MB |
Bone Health in Adults With Prader-Willi Syndrome : Clinical Recommendations Based on a Multicenter Cohort Study
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van Abswoude, Denise H. ;
Pellikaan, Karlijn ;
Rosenberg, Anna G. W. ;
Davidse, Kirsten ;
Coupaye, Muriel ;
Høybye, Charlotte ;
Markovic, Tania ;
Grugni, Graziano ;
Crinò, Antonino ;
Caixàs i Pedragós, Assumpta (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Poitou, Christine ;
Mosbah, Helena ;
Weir, Tessa ;
van Vlimmeren, Leo A. ;
Rutges, Joost P. H. J. ;
De Klerk, Luuk W. L. ;
Zillikens, M. Carola ;
van der Lely, Aart J. ;
de Graaff, Laura
Prader-Willi syndrome (PWS) is a rare complex genetic syndrome, characterized by delayed psychomotor development, hypotonia, and hyperphagia. Hormone deficiencies such as hypogonadism, hypothyroidism, and growth hormone deficiency are common. [...]
2022 - 10.1210/clinem/dgac556
The journal of clinical endocrinology & metabolism, Vol. 108 (september 2022) , p. 59-84
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6 p, 162.4 KB |
Growth Hormone Treatment and Papilledema : A Prospective Pilot Study
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Martín-Begué, Nieves (Hospital Universitari Vall d'Hebron) ;
Mogas, Eduard (Hospital Universitari Vall d'Hebron) ;
Dod, Charlotte Wolley (Hospital Universitari Vall d'Hebron) ;
Alarcón, Silvia (Hospital Universitari Vall d'Hebron) ;
Clemente, Maria (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Campos-Martorell, Ariadna (Universitat Autònoma de Barcelona) ;
Fábregas, Ana (Hospital Universitari Vall d'Hebron) ;
Yeste Fernández, Diego (Centro de Investigación Biomédica en Red de Enfermedades Raras)
To investigate the incidence of pseudotumor cerebri syndrome (PTCS) in children treated with growth hormone (GH) in a paediatric hospital and to identify risk factors for this complication. Prospective pilot study of paediatric patients treated with recombinant human GH, prescribed by the Paediatric Endocrinology Department, between February 2013 and September 2017. [...]
2021 - 10.4274/jcrpe.galenos.2020.2020.0007
Journal of Clinical Research in Pediatric Endocrinology, Vol. 13 (june 2021) , p. 146-151
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12 p, 3.3 MB |
A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness
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Dauber, Andrew (Division of Endocrinology, Children's National Hospital) ;
Meng, Yan (Broad Institute of MIT and Harvard) ;
Audí, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vedantam, Sailaja (Broad Institute of MIT and Harvard) ;
Weaver, Benjamin (Broad Institute of MIT and Harvard) ;
Carrascosa Lezcano, Antonio 1949- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Albertsson-Wikland, Kerstin (Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg) ;
Ranke, Michael B. (University Children's Hospital, Paediatric Endocrinology) ;
Jorge, Alexander A. L. (Unidade de Endocrinologia do Desenvolvimento (LIM42), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo) ;
Cara, Jose (Pfizer Inc, Rare Disease) ;
Wajnrajch, Michael P. (Pfizer Inc, Rare Disease) ;
Lindberg, Anders (Pfizer Inc, Data Management) ;
Camacho-Hübner, Cecilia (Pfizer Inc, Rare Disease) ;
Hirschhorn, Joel N. (Broad Institute of MIT and Harvard) ;
Universitat Autònoma de Barcelona
Individual patients vary in their response to growth hormone (GH). No large-scale genome-wide studies have looked for genetic predictors of GH responsiveness. To identify genetic variants associated with GH responsiveness. [...]
2020 - 10.1210/clinem/dgaa443
The journal of clinical endocrinology & metabolism, Vol. 105 (july 2020) , p. 3203-3214
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2 p, 125.6 KB |
Response to Letter to the Editor : "A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness"
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Hirschhorn, Joel N. (Broad Institute of MIT and Harvard) ;
Dauber, Andrew (Division of Endocrinology, Children's National Hospital) ;
Audí, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vedantam, Sailaja (Broad Institute of MIT and Harvard) ;
Ranke, Michael B. (University Children's Hospital, Paediatric Endocrinology) ;
Jorge, Alexander A. L. (Unidade de Endocrinologia do Desenvolvimento (LIM42), Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo) ;
Lindberg, Anders (Pfizer, Data Management) ;
Camacho-Hübner, Cecilia (Pfizer Inc, Rare Disease) ;
Wajnrajch, Michael P. (Pfizer Inc, Rare Disease) ;
Universitat Autònoma de Barcelona
2020 - 10.1210/clinem/dgaa735
The journal of clinical endocrinology & metabolism, Vol. 106 (november 2020) , p. e409-e410
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11 p, 746.0 KB |
Safety Outcomes During Pediatric GH Therapy : Final Results From the Prospective GeNeSIS Observational Program
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Child, Christopher J. (Eli Lilly and Company, Windlesham, Surrey, United Kingdom) ;
Zimmermann, Alan G. (Eli Lilly and Company, Indianapolis, Indiana) ;
Chrousos, George P. (National and Kapodistrian University of Athens, School of Medicine, Athens, Greece) ;
Cummings, Elisabeth (Dalhousie University/IWK Health Centre, Halifax, Nova Scotia, Canada) ;
Deal, Cheri L. (University of Montreal and CHU Ste-Justine, Montreal, Quebec, Canada) ;
Hasegawa, Tomonobu (Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan) ;
Jia, Nan (Eli Lilly and Company, Indianapolis, Indiana) ;
Lawrence, Sarah (Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada) ;
Linglart, Agnès (Hôpital Bicêtre Paris Sud, Paris, France) ;
Loche, Sandro (Ospedale Pediatrico Microcitemico "A. Cao," AO Brotzu, Cagliari, Italy) ;
Maghnie, Mohamad (Istituto Giannina Gaslini, University of Genova, Genoa, Italy) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Polak, Michel (Hôpital Universitaire Necker Enfants Malades and Université Paris Descartes, Centre des Maladies Endocrines Rares de la Croissance, Paris, France) ;
Predieri, Barbara (University of Modena and Reggio Emilia, Modena, Italy) ;
Richter-Unruh, Annette (University Children's Hospital, Bochum, Germany) ;
Rosenfeld, Ron G. (Oregon Health and Science University, Portland, Oregon) ;
Yeste Fernández, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Yorifuji, Tohru (Osaka City General Hospital, Miyakojima-ku, Osaka, Japan) ;
Blum, Werner F.. (University of Giessen, Giessen, Germany) ;
Universitat Autònoma de Barcelona
Safety concerns have been raised regarding premature mortality, diabetes, neoplasia, and cerebrovascular disease in association with GH therapy. To assess incidence of key safety outcomes. Prospective, multinational, observational study (1999 to 2015). [...]
2018 - 10.1210/jc.2018-01189
The journal of clinical endocrinology & metabolism, Vol. 104 (september 2018) , p. 379-389
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8 p, 2.2 MB |
Prevalence and Mortality of Individuals With X-Linked Hypophosphatemia : A United Kingdom Real-World Data Analysis
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Hawley, Samuel (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Shaw, Nick J. (Institute of Metabolism & Systems Research, University of Birmingham) ;
Delmestri, Antonella (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Pinedo-Villanueva, Rafael (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford) ;
Javaid, M. Kassim (MRC Lifecourse Epidemiology Unit, University of Southampton)
X-linked hypophosphatemia (XLH) is a rare multisystemic disease with a prominent musculoskeletal phenotype. We aim here to improve understanding of the prevalence of XLH across the life course and of overall survival among people with XLH. [...]
2020 - 10.1210/clinem/dgz203
The journal of clinical endocrinology & metabolism, Vol. 105 Num. 3 (March 2020)
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11 p, 1.7 MB |
Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population
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Esteban, Cristina (Hospital Universitari Vall d'Hebron) ;
Audí, Laura (Hospital Universitari Vall d'Hebron) ;
Carrascosa Lezcano, Antonio 1949- (Hospital Universitari Vall d'Hebron) ;
Fernández Cancio, Mónica (Hospital Universitari Vall d'Hebron) ;
Pérez-Arroyo, Annalisa (Hospital Universitari Vall d'Hebron) ;
Ulied, Angels (Hospital Universitari Vall d'Hebron) ;
Andaluz, Pilar (Hospital Universitari Vall d'Hebron) ;
Arjona, Rosa (Hospital Universitari Vall d'Hebron) ;
Albisu, Marian (Hospital Universitari Vall d'Hebron) ;
Clemente, Maria (Hospital Universitari Vall d'Hebron) ;
Gussinyer Canadell, Miquel (Hospital Universitari Vall d'Hebron) ;
Yeste Fernández, Diego (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions. The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height. [...]
2007 - 10.1111/j.1365-2265.2006.02718.x
Clinical Endocrinology, Vol. 66 (2 2007) , p. 258-268
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