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1.
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17 p, 4.7 MB |
Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
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Gallardo-Gómez, María (Universidade de Vigo) ;
Rodríguez-Girondo, Mar (Department of Medical Statistics and Bioinformatics. Leiden University Medical Centre) ;
Planell, Núria (Universidad Pública de Navarra) ;
Moran, Sebastián (Institut d'Investigació Biomèdica de Bellvitge) ;
Bujanda, Luis (Universidad del País Vasco. Instituto de Investigación Sanitaria Biodonostia) ;
Etxart, Ane (Department of Surgery. Hospital Universitario Donostia) ;
Castells, Antoni (Universitat de Barcelona) ;
Balaguer, Francesc (Universitat de Barcelona) ;
Jover, Rodrigo (Servicio de Medicina Digestiva. Universidad Miguel Hernández) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cubiella, Joaquin (Department of Gastroenterology. Complexo Hospitalario Universitario de Ourense. Instituto de Investigación Biomédica Galicia Sur. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gómez-Cabrero, David (Mucosal & Salivary Biology Division. King's College London Dental Institute) ;
De Chiara, Loretta (Galicia Sur Health Research Institute) ;
Universitat Autònoma de Barcelona
Background: Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. [...]
2023 -  10.1186/s13148-023-01570-1
Clinical Epigenetics, Vol. 15 Núm. 1 (december 2023) , p. 157
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2.
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19 p, 4.9 MB |
Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
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Chan, Donovan (Research Institute of the McGill University Health Centre) ;
Oros Klein, Kathleen (Jewish General Hospital) ;
Riera-Escamilla, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Krausz, Csilla (University of Florence) ;
O'Flaherty, Cristian (McGill University) ;
Chan, Peter (McGill University) ;
Robaire, Bernard (McGill University) ;
Trasler, Jacquetta M. (McGill University) ;
Universitat Autònoma de Barcelona
Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. [...]
2023 - 10.1186/s13148-022-01417-1
Clinical Epigenetics, Vol. 15 (january 2023)
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3.
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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4.
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11 p, 1.1 MB |
DNA methylation biomarkers of myocardial infarction and cardiovascular disease
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Fernández-Sanlés, Alba (Universitat Pompeu Fabra) ;
Sayols-Baixeras, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Subirana, I. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sentí, Mariano (Universitat Pompeu Fabra) ;
Pérez-Fernández, S. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Castro Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marrugat, Jaume 1954- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated loci associated with acute myocardial infarction (AMI) and assess their validity as predictive and causal biomarkers. [...]
2021 - 10.1186/s13148-021-01078-6
Clinical Epigenetics, Vol. 13 (April 2021) , art. 86
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5.
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13 p, 1.2 MB |
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA
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Ruiz Bañobre, Juan (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez Casanova, Aitor (Universidade de Santiago de Compostela) ;
Costa-Fraga, Nicolás (Universidade de Santiago de Compostela) ;
Bao Caamano, Aida (Universidade de Santiago de Compostela) ;
Álvarez Castro, Ana (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Carreras Presas, Martín (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Brozos Vázquez, Elena (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vidal Insua, Yolanda (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Vázquez Rivera, Francisca (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Candamio Folgar, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Mosquera Presedo, Manuel (Universidade de Santiago de Compostela) ;
Lago Lestón, Ramón M. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Vázquez Bueno, José Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Sanz Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno Aguado, Víctor (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Goel, Ajay (City of Hope Comprehensive Cancer Center) ;
Castillo, Lourdes (Advanced Marker Discovery) ;
Martín, Ana C. (Advanced Marker Discovery) ;
Arroyo, Rocío (Advanced Marker Discovery) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crujeiras, Ana B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
López López, Rafael (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Diaz-Lagares, Angel (Complejo Hospitalario Universitario de Santiago de Compostela)
Background: Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility of promoter methylation of the long noncoding RNA LINC00473 as a noninvasive biomarker to detect colorectal cancer and associated precancerous lesions. [...]
2022 - 10.1186/s13148-022-01302-x
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 86
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6.
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15 p, 1.1 MB |
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith-Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances
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Pignata, Laura (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Cecere, Francesco (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Verma, Ankit (Institute of Genetics and Biophysics (IGB)) ;
Hay Mele, Bruno (Università Degli Studi Di Napoli "Federico II") ;
Monticelli, Maria (Università Degli Studi Di Napoli "Federico II") ;
Acurzio, Basilia (Institute of Genetics and Biophysics (IGB)) ;
Giaccari, Carlo (Institute of Genetics and Biophysics (IGB)) ;
Sparago, Angela (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Hernandez Mora, José Ramon (Institut d'Investigació Biomèdica de Bellvitge) ;
Monteagudo-Sánchez, Ana (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pereda, Arrate (Araba University Hospital-Txagorritxu) ;
Tenorio-Castano, Jair (ITHACA. European Reference Network) ;
Palumbo, Orazio (Fondazione IRCCS "Casa Sollievo Della Sofferenza") ;
Carella, Massimo (Fondazione IRCCS "Casa Sollievo Della Sofferenza") ;
Prontera, Paolo (Medical Genetics Unit. University and Hospital of Perugia) ;
Piscopo, Carmelo ("Antonio Cardarelli" Hospital) ;
Accadia, Maria (Hospital "Cardinale G. Panico") ;
Lapunzina, Pablo (ITHACA. European Reference Network) ;
Cubellis, Maria Vittoria (Università Degli Studi Di Napoli "Federico II") ;
Pérez de Nanclares, Guiomar (Araba University Hospital-Txagorritxu) ;
Monk, David (University of East Anglia) ;
Riccio, Andrea (Institute of Genetics and Biophysics (IGB)) ;
Cerrato, Flavia (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Universitat Autònoma de Barcelona
Background: Beckwith-Wiedemann syndrome (BWS) and Pseudohypoparathyroidism type 1B (PHP1B) are imprinting disorders (ID) caused by deregulation of the imprinted gene clusters located at 11p15. 5 and 20q13. [...]
2022 - 10.1186/s13148-022-01292-w
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022), p. 71
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8.
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13 p, 1.3 MB |
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis
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Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (IRBLleida. Group of Molecular Oncology) ;
Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Li, Jing (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Vidal, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maggio, Valentina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aaltonen, Lauri A. (University of Helsinki) ;
Sánchez, Alex (Universitat de Barcelona. Departament d'Estadística) ;
Mariadason, John M. (La Trobe University. School of Cancer Medicine) ;
Arango, Diego (IRBLleida. Group of Molecular Oncology)
Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further investigation is required to systematically identify cancer driver genes regulated by promoter hypermethylation. [...]
2021 - 10.1186/s13148-021-01070-0
Clinical Epigenetics, Vol. 13 (april 2021)
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9.
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13 p, 1.6 MB |
MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma
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Vella, Serena (Ospedale Pediatrico Bambino Gesù) ;
Pomella, Silvia (Istituto Dermopatico dell'Immacolata) ;
Leoncini, Pier Paolo (Ospedale Pediatrico Bambino Gesù) ;
Colletti, Marta (Ospedale Pediatrico Bambino Gesù) ;
Conti, Beatrice (Ospedale Pediatrico Bambino Gesù) ;
Marquez, Victor E. (Frederick National Laboratory for Cancer Research) ;
Strillacci, Antonio (University of Bologna) ;
Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Milano, Giuseppe M. (Ospedale Pediatrico Bambino Gesù) ;
Capogrossi, Maurizio C. (Istituto Dermopatico dell'Immacolata) ;
Bertaina, Alice (Ospedale Pediatrico Bambino Gesù) ;
Ciarapica, Roberta (Istituto Dermopatico dell'Immacolata) ;
Rota, Rossella (Laboratory of Angiogenesis, Ospedale Pediatrico Bambino Gesù) ;
Universitat Autònoma de Barcelona
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 histone H3 methyltransferase that regulates the balance between cell proliferation and differentiation by epigenetically silencing muscle-specific genes. [...]
2015 - 10.1186/s13148-015-0107-z
Clinical Epigenetics, Vol. 7 (august 2015)
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10.
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14 p, 3.0 MB |
Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival
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Cabezón, Marta (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bargay, Joan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marcé, Silvia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garrido, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Tormo, M. (Hospital Clínic Universitari (València)) ;
Arenillas, Leonor (Hospital del Mar (Barcelona, Catalunya)) ;
Coll, Rosa (Hospital Universitari de Girona Doctor Josep Trueta) ;
Borrás, Josep (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Jiménez, María José (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Hoyos Colell, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Escoda, Lourdes (Hospital Universitari Joan XXIII de Tarragona) ;
Vall-Llovera, Ferran (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Garcia, A. (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Font, L. L. (Hospital de Tortosa Verge de la Cinta) ;
Ramila, Elena (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for intensive chemotherapy and/or allogeneic stem cell transplantation. [...]
2021 - 10.1186/s13148-021-01002-y
Clinical Epigenetics, Vol. 13 (january 2021)
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