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18 p, 3.4 MB Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection / Barmada, Anis (Department of Medical Genetics. University of Cambridge) ; Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ; Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ; Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ; Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ; Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ; Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Marchese, Domenica (Centre de Regulació Genòmica) ; Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Munera-Campos, Mónica (Institut Germans Trias i Pujol) ; Carrascosa, José Manuel (Institut Germans Trias i Pujol) ; Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Heyn, Holger (Universitat Pompeu Fabra) ; Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ; Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ; González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ; Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ; Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ; Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ; Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 - 10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633  
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2.
10 p, 868.0 KB Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells / Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ; Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ; Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ; Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ; Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ; Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ; Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ; Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ; Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ; Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69  
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