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10 p, 790.0 KB |
Assessment of the End Point Adjudication Process on the Results of the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial : A Secondary Analysis
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Farrant, Mary (University of California) ;
Easton, J.Donald (University of California) ;
Adelman, Eric E. (University of Wisconsin) ;
Cucchiara, Brett L. (University of Pennsylvania) ;
Barsan, Willian G. (University of Michigan) ;
Tillman, Holly J. (Medical University of South Carolina) ;
Elm, Jordan J. (Medical University of South Carolina) ;
Kim, Anthony S. (University of California) ;
Lindblad, Anne S. (Emmes Corporation) ;
Palesch, Yuyo Y. (Medical University of South Carolina) ;
Zhao, Wenle (Medical University of South Carolina) ;
Pauls, Keith (Medical University of South Carolina) ;
Walsh, Kyle B. (University of Cincinnati) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Bernstein, Richard A. (Northwestern University) ;
Johnston, Claiborne (University of Texas at Austin) ;
Universitat Autònoma de Barcelona
Debate continues about the value of event adjudication in clinical trials and whether independent centralized assessments improve reliability and validity of study results in masked randomized trials compared with local, investigator-assessed end points. [...]
2019 -  10.1001/jamanetworkopen.2019.10769
JAMA network open, Vol. 2 Núm. 9 (june 2019) , p. e1910769
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2.
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22 p, 12.5 MB |
Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment
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Crovetto, Francesca (Institut de Recerca Sant Joan de Déu) ;
Nakaki, Ayako (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Arranz, Angela (Hospital Sant Joan de Déu (Manresa)) ;
Borràs, Roger (Hospital Clínic i Provincial de Barcelona) ;
Vellvé, Kilian (Hospital Sant Joan de Déu (Manresa)) ;
Paules, Cristina (Hospital Sant Joan de Déu (Manresa)) ;
Boutet, Maria Laura (Hospital Sant Joan de Déu (Manresa)) ;
Castro-Barquero, Sara (Hospital Clínic i Provincial de Barcelona) ;
Freitas, Tania (Hospital Clínic i Provincial de Barcelona) ;
Casas, Rosa (Hospital Clínic i Provincial de Barcelona) ;
Martín-Asuero, Andrés (Instituto esMindfulness) ;
Oller Guzmán, Teresa (Instituto esMindfulness) ;
Morilla Figueras, Ivette (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Àran, Anabel (Hospital Clínic i Provincial de Barcelona) ;
Camacho, Alba (Hospital Sant Joan de Déu (Manresa)) ;
Pasqual, Mireia (Hospital Sant Joan de Déu (Manresa)) ;
Izquierdo Renau, Montserrat (Hospital Sant Joan de Déu (Manresa)) ;
Pozo, Oscar J (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gomez-Gomez, A. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Estruch, Ramón (Hospital Clínic i Provincial de Barcelona) ;
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Crispi, Fatima (Hospital Sant Joan de Déu (Manresa)) ;
Gratacos, Eduard (Hospital Sant Joan de Déu (Manresa)) ;
Universitat Autònoma de Barcelona
Is a Mediterranean diet or mindfulness-based stress reduction intervention during pregnancy effective in improving child neurodevelopment at age 2 years? In this randomized clinical trial that included 626 children, Bayley-III scores were significantly higher in cognitive and social-emotional domains in the Mediterranean diet group and significantly higher in the social-emotional domain in the stress reduction group compared with the usual care group. [...]
2023 - 10.1001/jamanetworkopen.2023.30255
JAMA network open, Vol. 6 (august 2023)
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13 p, 1009.5 KB |
Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days after Allogeneic Hematopoietic Stem Cell Transplant
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Dandoy, C.E. (Cincinnati Children's Hospital Medical Center) ;
Kim, S. (Medical College of Wisconsin) ;
Chen, M. (Medical College of Wisconsin) ;
Ahn, Kwang Woo (Medical College of Wisconsin) ;
Ardura, M.I. (Nationwide Children's Hospital) ;
Brown, V. (Penn State Hershey Children's Hospital) ;
Chhabra, Saurabh (Medical College of Wisconsin) ;
Diaz, M.A. (Hospital Infantil Universitario Nino Jesus) ;
Dvorak, C. (University of California) ;
Farhadfar, N. (University of Florida) ;
Flagg, A. (Yale New Haven Hospital) ;
Ganguly, S. (University of Kansas Health System) ;
Hale, G.A. (Johns Hopkins All Children's Hospital) ;
Hashmi, S.K. (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ;
Hematti, Peiman (University of Wisconsin) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Nishihori, T. (Lee Moffitt Cancer Center and Research Institute) ;
Nusrat, R. (Rutgers Robert Wood Johnson Medical School) ;
Olsson, R.F. (Uppsala University) ;
Rotz, S.J. (Cleveland Clinic Children's Hospital) ;
Sung, A.D. (Duke University School of Medicine) ;
Perales, M.A. (Memorial Sloan Kettering Cancer Center) ;
Lindemans, C.A. (Princess Maxima Center for Pediatric Oncology) ;
Komanduri, K.V. (University of Miami) ;
Riches, M.L. (University of North Carolina at Chapel Hill) ;
Universitat Autònoma de Barcelona
Importance: Patients undergoing hematopoietic stem cell transplant (HSCT) are at risk for bloodstream infection (BSI) secondary to translocation of bacteria through the injured mucosa, termed mucosal barrier injury-laboratory confirmed bloodstream infection (MBI-LCBI), in addition to BSI secondary to indwelling catheters and infection at other sites (BSI-other). [...]
2020 - 10.1001/jamanetworkopen.2019.18668
JAMA network open, Vol. 3 Núm. 1 (2020) , p. e1918668
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13 p, 851.6 KB |
Development and Validation of a Tool to Assess the Quality of Clinical Practice Guideline Recommendations
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Brouwers, M.C. (University of Ottawa) ;
Spithoff, K. (McMaster University (Canadà)) ;
Kerkvliet, K. (McMaster University (Canadà)) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Burgers, J. (Dutch College of General Practitioners) ;
Cluzeau, F. (St Mary's Hospital) ;
Férvers, B. (Centre León Bérard) ;
Graham, I. (University of Ottawa) ;
Grimshaw, J. (University of Ottawa) ;
Hanna, S. (McMaster University. Hamilton) ;
Kastner, M. (North York General Hospital) ;
Kho, M. (McMaster University (Canadà)) ;
Qaseem, Amir (American College of Physicians) ;
Straus, S. (Li Ka Shing Knowledge Institute of St. Michael's Hospital) ;
Florez, I.D. (University of Antioquia) ;
Universitat Autònoma de Barcelona
Clinical practice guidelines (CPGs) may lack rigor and suitability to the setting in which they are to be applied. Methods to yield clinical practice guideline recommendations that are credible and implementable remain to be determined. [...]
2020 - 10.1001/jamanetworkopen.2020.5535
JAMA network open, Vol. 3 Núm. 5 (27 2020) , p. 5535
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15 p, 2.7 MB |
Longitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome
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Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, Susana (Fundació Catalana Síndrome de Down) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Garzón, Diana (Institut d'Investigació Biomèdica Sant Pau) ;
Ribas, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Arranz Martínez, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Aranha, Mateus (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Cés, Sebastià (Institut d'Investigació Biomèdica de Bellvitge) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Are age, intellectual disability (ID), and clinical status associated with Alzheimer disease (AD) progression and longitudinal cognitive decline in adults with Down syndrome (DS)? In this cohort study of 632 adults with DS, there was a high age-dependent risk of developing symptomatic AD but not the prodromal stage of the disease. [...]
2022 - 10.1001/jamanetworkopen.2022.25573
JAMA network open, Vol. 5 (august 2022)
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14 p, 1.1 MB |
Imaging Response to Contemporary Immuno-oncology Combination Therapies in Patients With Metastatic Renal Cell Carcinoma
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Navani, Vishal (University of Calgary) ;
Ernst, Matthew (University of Calgary) ;
Wells, J. Connor (BC Cancer Agency) ;
Yuasa, Takeshi (Japanese Foundation for Cancer Research) ;
Takemura, Kosuke (Japanese Foundation for Cancer Research) ;
Donskov, Frede (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Basappa, Naveen S. (University of Alberta) ;
Schmidt, Andrew (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Pal, Sumanta K. (City of Hope Comprehensive Cancer Center) ;
Meza, Luis (City of Hope Comprehensive Cancer Center) ;
Wood, Lori A. (Queen Elizabeth II Health Sciences Centre) ;
Ernst, D. Scott (London Regional Cancer Centre) ;
Szabados, Bernadett (Queen Mary University of London) ;
Powles, Thomas (Queen Mary University of London) ;
McKay, Rana R. (University of California) ;
Weickhardt, Andrew (Olivia Newton-John Cancer and Wellness Centre) ;
Suárez, Cristina (Hospital Universitari Vall d'Hebron) ;
Kapoor, Anil (McMaster University (Canadà)) ;
Lee, Jae Lyun (University of Ulsan College of Medicine) ;
Choueiri, Toni K. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Heng, Daniel Y. C. (University of Calgary) ;
Universitat Autònoma de Barcelona
Do contemporary first-line therapy options for metastatic renal cell carcinoma (mRCC) have different likelihoods of objective imaging response (complete or partial response), and is objective imaging response associated with overall survival? In this cohort study involving 899 patients with mRCC, treatment with immune checkpoint blockade plus vascular endothelial growth factor receptor inhibitor combination therapies was more likely to be associated with objective imaging response than doublet immune checkpoint blockade therapy after adjustment for baseline demographic and clinical characteristics, including International Metastatic Renal Cell Carcinoma Database Consortium risk criteria. [...]
2022 - 10.1001/jamanetworkopen.2022.16379
JAMA network open, Vol. 5 (june 2022)
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15 p, 1.3 MB |
Association of Alzheimer Disease with Life Expectancy in People with Down Syndrome
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Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Garzón Chavez, Diana (Center of Biomedical Investigation Network for Neurodegenerative Diseases) ;
Klitgaard Christensen, Maria (National Centre for Register-based Research. Aarhus University) ;
Valle-Tamayo, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Plana-Ripoll, Oleguer (National Centre for Register-based Research. Aarhus University) ;
Rasmussen, Sonja A. (Department of Epidemiology. University of Florida. College of Public Health and Health Professions. College of Medicine) ;
Roqué i Figuls, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez, Susana (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Center of Biomedical Investigation Network for Neurodegenerative Diseases) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Importance: People with Down syndrome have a high risk of developing Alzheimer disease dementia. However, penetrance and age at onset are considered variable, and the association of this disease with life expectancy remains unclear because of underreporting in death certificates. [...]
2022 - 10.1001/jamanetworkopen.2022.12910
JAMA network open, 2022
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16 p, 2.1 MB |
Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration
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Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Nigro, Salvatore (Institute of Nanotechnology. National Research Council) ;
Vandevrede, Lawren (Memory and Aging Center. Department of Neurology. University of California) ;
Falgàs, Neus (Memory and Aging Center. Department of Neurology. University of California) ;
Heuer, Hilary W. (Memory and Aging Center. Department of Neurology. University of California) ;
Painous, Cèlia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Compta, Yaroslau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martí, Maria J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Logroscino, Giancarlo (Department of Basic Medicine. Neuroscience. and Sense Organs. University of Bari Aldo Moro) ;
Quattrone, Andrea (Neuroimaging Research Unit. Institute of Molecular Bioimaging and Physiology. National Research Council) ;
Perry, David C. (Memory and Aging Center. Department of Neurology. University of California) ;
Gorno-Tempini, Maria Luisa (Memory and Aging Center. Department of Neurology. University of California) ;
Rosen, Howard J. (Memory and Aging Center. Department of Neurology. University of California) ;
Grinberg, Lea T. (Memory and Aging Center. Department of Neurology. University of California) ;
Spina, Salvatore (Memory and Aging Center. Department of Neurology. University of California) ;
La Joie, Renaud (Memory and Aging Center. Department of Neurology. University of California) ;
Rabinovici, Gil D. (Memory and Aging Center. Department of Neurology. University of California) ;
Miller, Bruce L. (University of California, San Francisco (UCSF)) ;
Rojas, Julio C. (Memory and Aging Center. Department of Neurology. University of California) ;
Seeley, William W. (Memory and Aging Center. Department of Neurology. University of California) ;
Boxer, Adam (Memory and Aging Center. Department of Neurology. University of California) ;
Universitat Autònoma de Barcelona
Importance: The accurate diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is hampered by imperfect clinical-pathological correlations. Objective: To assess and compare the diagnostic value of the magnetic resonance parkinsonism index (MRPI) and other magnetic resonance imaging-based measures of cerebral atrophy to differentiate between PSP, CBD, and other neurodegenerative diseases. [...]
2022 - 10.1001/jamanetworkopen.2022.9588
JAMA network open, Vol. 5 Núm. 4 (january 2022) , p. E229588
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10 p, 391.9 KB |
Ponesimod Compared with Teriflunomide in Patients with Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study : A Randomized Clinical Trial
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Kappos, Ludwig (University of Basel) ;
Fox, Robert J. (Cleveland Clinic) ;
Burcklen, Michel (Actelion Pharmaceuticals) ;
Freedman, Mark S. (University of Ottawa) ;
Kubala Havrdova, Eva (Charles University) ;
Hennessy, Brian (Actelion Pharmaceuticals) ;
Hohlfeld, Reinhard (Ludwig Maximilians University Munich) ;
Lublin, Fred (Icahn School of Medicine at Mount Sinai) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Pozzilli, Carlo (Sapienza University of Rome) ;
Scherz, Tatiana (Actelion Pharmaceuticals) ;
D'Ambrosio, Daniele (Galapagos GmbH) ;
Linscheid, Philippe (Actelion Pharmaceuticals) ;
Vaclavkova, Andrea (Actelion Pharmaceuticals) ;
Pirozek-Lawniczek, Magdalena (Actelion Pharmaceuticals) ;
Kracker, Hilke (Actelion Pharmaceuticals) ;
Sprenger, Till (University of Basel) ;
Universitat Autònoma de Barcelona
Importance: To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease-modifying therapies for relapsing multiple sclerosis (RMS). [...]
2021 - 10.1001/jamaneurol.2021.0405
JAMA Neurology, Vol. 78 Núm. 5 (may 2021) , p. 558-567
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10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
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