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18 p, 1.8 MB |
Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection
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Gallardo-Gómez, María (Universidade de Vigo) ;
Costas-Ríos, Lara (Universidade de Vigo) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Rodríguez, Lara (Universidade de Vigo) ;
Bujanda, Luis (Universidad del País Vasco (UPV/EHU)) ;
Barrero, Maialen (Hospital Universitario Donostia) ;
Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ;
González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ;
Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ;
De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 -  10.1002/1878-0261.13573
Molecular Oncology, 2023
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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 - 10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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19 p, 7.4 MB |
Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma
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Caillot, Mélody (Normandie Université) ;
Miloudi, Hadjer (Normandie Université) ;
Taly, Antoine (IPSL Research University) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos, Juliana C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribeiro, Marcelo L. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Maitre, Elsa (CHU Côte de Nacre) ;
Saule, Simon (Université Paris-Sud) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jardin, Fabrice (Centre de lutte contre le cancer Henri Becquerel) ;
Sola, Brigitte (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Miloudi, Hadjer (Normandie Université)
Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to inhibit XPO1. [...]
2023 - 10.1002/1878-0261.13386
Molecular Oncology, Vol. 17 Núm. 12 (december 2023) , p. 2546-2564
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13 p, 828.8 KB |
Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions
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Villatoro, Sergi (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-de-las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri-Ramírez, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón-Ibañez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Moya-Horno, Irene (Hospital General de Catalunya) ;
García-Peláez, Beatrtiz (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Malapelle, Umberto (University of Naples Federico II) ;
Balada-Bel, Ariadna (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Campos, Raquel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Remei (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Blasco, Ana (Hospital General Universitari de València) ;
Catalán, María J. (Grup Quirónsalud (Barcelona, Catalunya)) ;
González, Xavier (Hospital General de Catalunya) ;
Troncone, Giancarlo (University of Naples Federico II) ;
Karachaliou, Niki (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations and guide treatment decisions. [...]
2019 - 10.1002/1878-0261.12574
Molecular Oncology, Vol. 13 Núm. 12 (january 2019) , p. 2633-2645
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13 p, 368.5 KB |
Dynamic changes in circulating tumor assessed by shallow whole-genome sequencing associate with clinical efficacy of checkpoint inhibitors in
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Carbonell, Caterina (Vall d'Hebron Institut d'Oncologia) ;
Frigola Rissech, Joan (Vall d'Hebron Institut d'Oncologia) ;
Pardo Aranda, Nuria (Vall d'Hebron Institut d'Oncologia) ;
Callejo, Ana (Vall d'Hebron Institut d'Oncologia) ;
Iranzo, Patricia (Vall d'Hebron Institut d'Oncologia) ;
Valdivia, Augusto (Vall d'Hebron Institut d'Oncologia) ;
Priano, Ilaria (Vall d'Hebron Institut d'Oncologia) ;
Cedrés, Susana (Vall d'Hebron Institut d'Oncologia) ;
Martinez-Marti, Alex (Vall d'Hebron Institut d'Oncologia) ;
Navarro, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Lenza, Laura (Vall d'Hebron Institut d'Oncologia) ;
Soleda, Mireia (Vall d'Hebron Institut d'Oncologia) ;
Gonzalo-Ruiz, Javier (Vall d'Hebron Institut d'Oncologia) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Sansó, Miriam (Institut d'Investigació Sanitària Illes Balears) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Amat, Ramon (Vall d'Hebron Institut d'Oncologia) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis are the main therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) without a druggable oncogenic alteration. [...]
2023 - 10.1002/1878-0261.13409
Molecular Oncology, Vol. 17 (march 2023) , p. 779-791
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14 p, 586.6 KB |
Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial
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Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Jantus-Lewintre, Eloisa (Universitat Politècnica de València) ;
García-Peláez, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Royuela, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
Cruz Castellanos, Patricia (Hospital Universitario La Paz (Madrid)) ;
Collazo-Lorduy, Ana (Hospital Universitario HM Sanchinarro (Madrid)) ;
Pérez Altozano, Javier (Hospital Virgen de los Lirios) ;
Vidal, Oscar Juan (Hospital Universitari i Politècnic La Fe (València)) ;
Diz Taín, P (Complejo Asistencial Universitario de León) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
Hernández, Berta (Complejo Hospitalario de Navarra) ;
Vázquez Estevez, Sergio (Hospital Universitario Lucus Augusti (Lugo)) ;
Benítez, Gretel (Complejo Hospitalario Universitario Insular de Gran Canaria) ;
Guirado, Maria (Hospital General Universitario de Elche) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Ortega Granados, Ana Laura (Complejo Hospitalario de Jaén) ;
Blasco, Ana (Centro de Investigación Biomédica en Red de Cáncer) ;
Bosch-Barrera, J (Institut d'Investigació Biomèdica de Girona) ;
Jurado, Jose M. (Hospital Universitario San Cecilio (Granada)) ;
García González, Jorge (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Viteri, Santiago (Instituto Oncológico Dr. Rosell. Hospital Universitario Dexeus. Grupo Quiron Salud) ;
Garcia Giron, Carlos (Hospital Universitario de Burgos) ;
Massuti, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Lopez Martín, Ana (Hospital Universitario Severo Ochoa) ;
Rodriguez-Festa, Alejandro (Fundación de Investigación Biomédica del H.U. Puerta de Hierro Majadahonda) ;
Calabuig-Fariñas, Silvia (Universitat de València. Departament de Patologia) ;
Molina-Vila, Miguel Ángel (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. [...]
2021 - 10.1002/1878-0261.12832
Molecular Oncology, Vol. 15 Núm. 1 (january 2021) , p. 43-56
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17 p, 1.3 MB |
The transcribed ultraconserved region uc.160+ enhances processing and A-to-I editing of the miR-376 cluster : hypermethylation improves glioma prognosis
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Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez Castillo, Anaís (Maastricht University Medical Center) ;
Mora Martínez, Carlos (University of Helsinki) ;
Setién, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Siqueira, E (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Transcribed ultraconserved regions (T-UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T-UCRs as regulators of gene expression has been proposed, their functions remain largely unknown. [...]
2022 - 10.1002/1878-0261.13121
Molecular Oncology, Vol. 16 Núm. 3 (february 2022) , p. 648-664
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21 p, 3.1 MB |
Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia
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Ramos-Muntada, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blanco, Joan (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Cortez, Virginia Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bataller, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Millán, Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Schwab, Claire (Newcastle University. Wolfson Childhood Cancer Research Centre) ;
Ortega, Margarita (Vall d'Hebron Institut d'Oncologia) ;
Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Blanco, María L. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Nomdedeu, Josep (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ramírez, Manuel (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Minguela, Alfredo (Instituto Murciano de Investigación Biosanitaria) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Cuatrecasas, Esther (Institut de Recerca Sant Joan de Déu) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Ballerini, Paola (Hôpital A. Trousseau) ;
Escherich, Gabriele (Department of Pediatric Hematology and Oncology. University Medical Center Hamburg) ;
Boer, Judith (Oncode Institute) ;
DenBoer, Monique (Erasmus MC - Sophia Children's Hospital) ;
Hernández-Rivas, Jesús M. (Instituto de Investigación Biomédica de Salamanca) ;
Calasanz, M.J (Universidad de Navarra) ;
Cazzaniga, Giovanni (Fondazione Tettamanti) ;
Harrison, Christine J. (Newcastle University. Wolfson Childhood Cancer Research Centre) ;
Menéndez Bujan, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Molina, Oscar (Red Española de Terápias AvanzadasI)
B-cell acute lymphoblastic leukemia (B-ALL) is the commonest childhood cancer. High hyperdiploidy (HHD) identifies the most frequent cytogenetic subgroup in childhood B-ALL. Although hyperdiploidy represents an important prognostic factor in childhood B-ALL, the specific chromosome gains with prognostic value in HHD-B-ALL remain controversial, and the current knowledge about the hierarchy of chromosome gains, clonal heterogeneity and chromosomal instability in HHD-B-ALL remains very limited. [...]
2022 - 10.1002/1878-0261.13276
Molecular Oncology, Vol. 16 Núm. 16 (august 2022) , p. 2899-2919
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