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19 p, 1.5 MB |
Short-Term Changes in Left and Right Ventricular Cardiac Magnetic Resonance Feature Tracking Strain Following Ferric Carboxymaltose in Patients With Heart Failure : A Substudy of the Myocardial-IRON Trial
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del Canto, Irene (Universitat Politècnica de València) ;
Santas, Enrique (Hospital Clínico Universitario de Valencia) ;
Cardells, Ingrid (Hospital de Manises (València)) ;
Miñana, Gema (Hospital Clínico Universitario de Valencia) ;
Palau, Patricia (Hospital Clínico Universitario de Valencia) ;
Llàcer, Pau (Hospital de Manises (València)) ;
Fácila, Lorenzo (Hospital General Universitario de Valencia) ;
López-Vilella, Raquel (Hospital Universitari i Politècnic La Fe (València)) ;
Almenar Bonet, Luis (Hospital Universitari i Politècnic La Fe (València)) ;
Bodi, Vicente (Hospital Clínico Universitario de Valencia) ;
López-Lereu, Maria P. (Cardiovascular Imaging Unit Ascires Biomedical Group) ;
Monmeneu, Jose V. (Cardiovascular Imaging Unit Ascires Biomedical Group) ;
Sanchis, Juan (Universitat de Valencia) ;
Moratal, David (Universitat Politècnica de València) ;
Maceira, Alicia M. (Universitat de Valencia) ;
De la Espriella, Rafael (Universitat de Valencia) ;
Chorro, Francisco J. (Universitat de Valencia) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona) ;
Núñez, Julio (Universitat de Valencia)
The mechanisms explaining the clinical benefits of ferric carboximaltose (FCM) in patients with heart failure, reduced or intermediate left ventricular ejection fraction, and iron deficiency remain not fully clarified. [...]
2022 -  10.1161/JAHA.121.022214
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 11 (march 2022)
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14 p, 1.6 MB |
Circulating virome and inflammatory proteome in patients with ST-elevation myocardial infarction and primary ventricular fibrillation
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Oliveras, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garcia Garcia, Cosme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cserkóová, Adriana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rueda, Ferran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Labata, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer Vinardel, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Montero, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
El-Ouaddi, Nabil (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Primary ventricular fibrillation (PVF) is a life-threatening complication of ST-segment elevation myocardial infarction (STEMI). It is unclear what roles viral infection and/or systemic inflammation may play as underlying triggers of PVF, as a second hit in the context of acute ischaemia. [...]
2022 - 10.1038/s41598-022-12075-x
Scientific reports, Vol. 12, Num 1 (may 2022)
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10 p, 7.4 MB |
Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure : A Longitudinal Analysis
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Miñana, Gema (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Lorenzo, Miguel (Hospital Clínic Universitari (València)) ;
Ramirez de Arellano, Antonio (HEOR, Viforpharma Group, Zurich, Switzerland) ;
Wächter, Sandra (Medical Department, Viforpharma Group, Zurich, Switzerland) ;
De la Espriella, Rafael (CIBER Cardiovascular, Madrid) ;
Sastre, Clara (Hospital Clínic Universitari (València)) ;
Mollar, Anna (Hospital Clínic Universitari (València)) ;
Núñez, Eduardo (Hospital Clínic Universitari (València)) ;
Bodi, Vicente (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Sanchis, Juan (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Núñez, Julio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
In patients with heart failure (HF), iron deficiency (ID) is a well-recognized therapeutic target; information about its incidence, patterns of iron repletion, and clinical impact is scarce. This single-centre longitudinal cohort study assessed the rates of ID testing and diagnosis in patients with stable HF, patterns of treatment with intravenous iron, and clinical impact of intravenous iron on HF rehospitalization risk. [...]
2022 - 10.3390/jcm11092559
Journal of clinical medicine, Vol. 11 (may 2022)
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7 p, 2.2 MB |
Therapeutic inertia in the pharmacological management of heart failure with reduced ejection fraction
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Girerd, Nicolas (F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists)) ;
Von Hunolstein, Jean-Jacques (Strasbourg University Hospital) ;
Pellicori, Pierpaolo (University of Glasgow) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona) ;
Jaarsma, Tiny (Linköping University) ;
Lund, Lars H. (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Bilbault, Pascal (University of Strasbourg) ;
Boivin, Jean-Marc (Université de Lorraine) ;
Chouihed, Tahar (University Hospital of Nancy) ;
Costa, Jérôme (Centre hospitalo-universitaire de Reims) ;
Eicher, Jean-Christophe (CHU Dijon) ;
Fall, Estelle (Université de Lorraine) ;
Kenizou, David (Hôpital Emile Muller) ;
Maillier, Bruno (Centre hospitalier de Troyes) ;
Nazeyrollas, Pierre (Centre hospitalo-universitaire de Reims) ;
Roul, Gérald (Hôpitaux Universitaires de Strasbourg) ;
Zannad, Noura (Regional Hospital, Mercy Hospital) ;
Rossignol, Patrick (Cardiovascular and Renal Clinical Trialists) ;
Seronde, Marie-France (University of Burgundy Franche-Comté Besançon) ;
universitat Autònoma de Barcelona
2022 - 10.1002/ehf2.13929
ESC Heart Failure, Vol. 9 (april 2022) , p. 2063-2069
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23 p, 1.2 MB |
Circulating heart failure biomarkers beyond natriuretic peptides : review from the Biomarker Study Group of the Heart Failure Association (), European Society of Cardiology ()
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Meijers, Wouter C. (University Medical Center Groningen, The Netherlands) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mebazaa, Alexandre (Université de Paris) ;
Bauersachs, Johann (Hannover Medical School, Germany) ;
Cleland, John G.F. (University of Glasgow) ;
Coats, Andrew J. S. (University of Warwick, Coventry, UK) ;
Januzzi, James L. (Massachusetts General Hospital, Boston, USA) ;
Maisel, Alan S. (University of California, USA) ;
McDonald, Kenneth (St Vincent's University Hospital, Dublin, Ireland) ;
Mueller, Thomas (Hospital of Bolzano, Italy) ;
Richards, A. Mark (National University of Singapore) ;
Seferovic, Petar (Belgrade University, Serbia) ;
Mueller, Christian (University of Basel, Switzerland) ;
de Boer, Rudolf A. (University Medical Center Groningen, The Netherlands) ;
Universitat Autònoma de Barcelona
New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. [...]
2021 - 10.1002/ejhf.2346
European Journal of Heart Failure, Vol. 23 (october 2021) , p. 1610-1632
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12 p, 1.2 MB |
Major Adverse Cardiovascular Events and Mortality Prediction by Circulating GDF-15 in Patients with Type 2 Diabetes : A Systematic Review and Meta-Analysis
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Xie, Suyi (The Chinese University of Hong Kong) ;
Li, Qi (The Chinese University of Hong Kong) ;
Luk, Andrea O. Y. (The Chinese University of Hong Kong) ;
Lan, Hui-Yao (The Chinese University of Hong Kong) ;
Chan, Paul K. S. (The Chinese University of Hong Kong) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Chan, Francis K. L. (The Chinese University of Hong Kong) ;
Fung, Erik (The Chinese University of Hong Kong) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Growth differentiation factor 15 (GDF-15) is a homeostatic cytokine that regulates neural and cardio-metabolic functions, and its release is increased in response to stress, injury, and inflammation. [...]
2022 - 10.3390/biom12070934
Biomolecules, Vol. 12, Num. 7 (july 2022)
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5 p, 420.5 KB |
Evolocumab has no effects on heart failure with reduced ejection fraction injury biomarkers : The EVO-HF trial
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Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol) ;
Llibre, Cinta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rangel-Sousa, Diego (Hospital Universitario Virgen del Rocío (Andalusia)) ;
Fernández-Cisnal, Agustín (Fundación Investigación Clínico de Valencia-Instituto de Investigación Sanitaria) ;
Miñana, Gema (Universitat de València. Departament de Medicina) ;
Mollar, Anna (Fundación Investigación Clínico de Valencia-Instituto de Investigación Sanitaria) ;
Núñez, Julio (Universitat de València. Departament de Medicina)
Aim: Patients with heart failure with reduced ejection fraction (HFrEF) have not been shown to benefit from statins. We hypothesized that, by limiting disease progression in stable HFrEF of ischaemic etiology, the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab could reduce circulating troponin levels, a surrogate biomarker of myocyte injury and atherosclerosis progression. [...]
2023 - 10.1002/ejhf.2932
European Journal of Heart Failure, Vol. 25 Núm. 8 (august 2023) , p. 1439-1443
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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 - 10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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