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1.
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11 p, 618.2 KB |
Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities : Laboratory tools for an early and differential diagnosis
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Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Fernández, Sara (Hospital Clínic i Provincial de Barcelona) ;
Ventosa, Helena (Hospital Clínic i Provincial de Barcelona) ;
Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramos, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ;
Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ;
Fernández De Larrea, Carlos (Hospital Clínic i Provincial de Barcelona) ;
Urbano-Ispizua, Alvaro (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Charité Universitätsmedizin Berlin, Germany) ;
Nicolás, J.M. (Hospital Clínic i Provincial de Barcelona) ;
Téllez, Adrian (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Avilés, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Castro Rebollo, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Background Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated neurotoxicity syndromes are life-threatening toxicities in which the endothelium could be a pathophysiological substrate. [...]
2023 -  10.1136/jitc-2022-006365
Journal for immunotherapy of cancer, Vol. 11 Núm. 4 (april 2023)
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2.
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13 p, 1.2 MB |
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy : A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research
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Schoettler, M.L. (Children's Healthcare of Atlanta) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cho, Byung-Sik (The Catholic University of Korea) ;
Dandoy, Christopher E. (Cincinnati Children's Hospital Medical Center) ;
Ho, Vincent Trien Vinh (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Jodele, Sonata (Cincinnati Children's Hospital Medical Center) ;
Moissev, I. (Pavlov First Saint Petersburg State Medical University) ;
Sańchez Ortega, Isabel (European Society for Bone Marrow Transplant) ;
Srivastava, Alok (Christian Medical College Vellore) ;
Atsuta, Yoshiko (Aichi Medical University) ;
Carpenter, Paul A. (Seattle Children's Hospital) ;
Koreth, John (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Kröger, Nicolaus M. (Ohio State. University) ;
Ljungman, Per (Karolinska Institutet (Estocolm, Suècia)) ;
Page, Kristin M. (Medical College of Wisconsin) ;
Popat, Uday R. (The University of Texas MD Anderson Cancer Center) ;
Shaw, Bronwen E. (Medical College of Wisconsin) ;
Sureda Balari, Anna Maria (Institut Catala d'Oncologia-Hospital Duran i Reynals) ;
Soiffer, Robert J. (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Vasu, Sumithira V. (Ohio State. University)
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of hematopoietic cell transplantation (HCT) associated with significant morbidity and mortality. [...]
2023 - 10.1016/j.jtct.2022.11.015
Transplantation and Cellular Therapy, Vol. 29 Núm. 3 (march 2023) , p. 151-163
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3.
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10 p, 3.0 MB |
Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era
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Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Charry, Paola (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Solano, María Teresa (Hospital Clínic i Provincial de Barcelona) ;
Arcarons, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lozano, Miquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Esteve, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. [...]
2023 - 10.1016/j.htct.2023.07.008
Hematology, Transfusion and Cell Therapy, 2023
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4.
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12 p, 7.7 MB |
Differential protein expression in endothelial cells exposed to serum from patients with acute graft-vs-host disease, depending on steroid response
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Gines (Hospital Clínic i Provincial de Barcelona) ;
Penack, Olaf (Universität zu Berlin, Germany) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Graft-versus-host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury is crucial as pathophysiological substrate for GVHD. GVHD first-line treatment is high-dose corticosteroids, although some patients are steroid-refractory. [...]
2023 - 10.1111/jcmm.17712
Journal of Cellular and Molecular Medicine, Vol. 27 Núm. 9 (may 2023) , p. 1227-1238
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5 p, 178.9 KB |
Outcome of Second Allogeneic Hematopoietic Cell Transplantation after Relapse of Myeloid Malignancies following Allogeneic Hematopoietic Cell Transplantation : A Retrospective Cohort on Behalf of the Grupo Español de Trasplante Hematopoyetico
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Orti, Guillermo (Grupo Español de Trasplante Hematopoyetico) ;
Sanz, Jaime (Grupo Español de Trasplante Hematopoyetico) ;
Bermúdez, Arancha (Grupo Español de Trasplante Hematopoyetico) ;
Caballero, Dolores (Grupo Español de Trasplante Hematopoyetico) ;
Martinez, Carmen (Grupo Español de Trasplante Hematopoyetico) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Cabrera Marin, José R. (Grupo Español de Trasplante Hematopoyetico) ;
Espigado, Ildefonso (Grupo Español de Trasplante Hematopoyetico) ;
Solano, Carlos (Grupo Español de Trasplante Hematopoyetico) ;
Ferrà, Christelle (Grupo Español de Trasplante Hematopoyetico) ;
García-Noblejas, Ana (Grupo Español de Trasplante Hematopoyetico) ;
Jimenez, Santiago (Grupo Español de Trasplante Hematopoyetico) ;
Sampol, Antonia (Grupo Español de Trasplante Hematopoyetico) ;
Yañez, Lucrecia (Grupo Español de Trasplante Hematopoyetico) ;
García-Gutiérrez, Valentin (Grupo Español de Trasplante Hematopoyetico) ;
Pascual, Maria Jesus (Grupo Español de Trasplante Hematopoyetico) ;
Jurado, Manuel (Grupo Español de Trasplante Hematopoyetico) ;
Moraleda, José M. (Grupo Español de Trasplante Hematopoyetico) ;
Valcarcel, David (Grupo Español de Trasplante Hematopoyetico) ;
Sanz, Miguel A. (Grupo Español de Trasplante Hematopoyetico) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Duarte, Rafael F. (Grupo Español de Trasplante Hematopoyetico) ;
Universitat Autònoma de Barcelona
Allogeneic stem cell transplantation (allo-HCT) represents the most effective immunotherapy for acute myeloid leukemia (AML) and myeloid malignancies. However, disease relapse remains the most common cause of treatment failure. [...]
2016 - 10.1016/j.bbmt.2015.11.012
Biology of blood and marrow transplantation, Vol. 22 Núm. 3 (january 2016) , p. 584-588
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3 p, 444.0 KB |
Prevention of veno-occlusive disease/sinusoidal obstruction syndrome : a never-ending story and no easy answer
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Corbacioglu, Selim (University of Regensburg) ;
Grupp, S.A. (The Children's Hospital of Philadelphia) ;
Richardson, Paul G.. (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Duarte, R. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pagliuca, A. (King's College Hospital and Anthony Nolan Research Institute) ;
Ruutu, T. (Helsinki University Hospital) ;
Mahadeo, K. (Duke University Children's Hospital) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2023 - 10.1038/s41409-023-02007-2
Bone marrow transplantation, Vol. 58 Núm. 8 (august 2023) , p. 839-841
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17 p, 2.0 MB |
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy
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Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Youssef, Lina (BCNatal (Hospital Clínic and Hospital Sant Joan de Déu)) ;
Ramos, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torramade-Moix, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bonastre, Laura (Hospital Clínic i Provincial de Barcelona) ;
Pino, Marc (Hospital Clínic i Provincial de Barcelona) ;
Gomez-Ramirez, Pilar (Hospital Clínic i Provincial de Barcelona) ;
Martin, Lidia (Hospital Clínic i Provincial de Barcelona) ;
Garcia Mateos, Estefania (Hospital Clínic i Provincial de Barcelona) ;
Sanchez, Pablo (Institut de Ciències del Mar) ;
Fernandez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Crovetto, Francesca (Hospital Clínic i Provincial de Barcelona) ;
Escolar, Ginés (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro Rebollo, Pedro (Universitat de Barcelona) ;
Gratacos, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Crispi, Fatima (Hospital Clínic i Provincial de Barcelona) ;
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Background: COVID-19 presents a spectrum of signs and symptoms in pregnant women that might resemble preeclampsia. Differentiation between severe COVID-19 and preeclampsia is difficult in some cases. [...]
2022 - 10.1016/j.ajog.2022.03.048
American Journal of Obstetrics and Gynecology, Vol. 227 Núm. 2 (august 2022)
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5 p, 105.6 KB |
Estructura i Transmissió d'Informació [104751]
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Vergara Carreras, Enric ;
Universitat Autònoma de Barcelona.
Facultat de Ciències de la Comunicació
Els principals objectius de l'assignatura són: • Assolir una visió general dels conceptes relacionats amb les xarxes d'ordinadors i amb la interconnexió de xarxes heterogènies, en especial Internet. [...]
The main objectives of the course are: • Achieve a general vision of the concepts related to computer networks and the interconnection of heterogeneous networks, especially the Internet. • Understand the operation of the protocols related to the operation of interconnected networks. [...]
Los principales objetivos de la asignatura son: • Alcanzar una visión general de los conceptos relacionados con las redes de ordenadores y con la interconexión de redes heterogéneas, en especial Internet. [...]
2023-24
Grau en Comunicació Interactiva [1423]
3 documents
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9.
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12 p, 1.3 MB |
Thrombotic microangiopathies assessment : mind the complement
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Blasco Pelicano, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guillén, Elena (Hospital Clínic i Provincial de Barcelona) ;
Quintana, Luis F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Garcia-Herrera, Adriana (Hospital Clínic i Provincial de Barcelona) ;
Piñeiro, Gastón (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Poch, Esteban (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campistol Plana, Josep M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palomo, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
When faced withmicroangiopathic haemolytic anaemia, thrombocytopenia and organ dysfunction, clinicians should suspect thromboticmicroangiopathy (TMA). The endothelial damage that leads to this histological lesion can be triggered by several conditions or diseases, hindering an early diagnosis and aetiological treatment. [...]
2021 - 10.1093/ckj/sfaa195
Clinical Kidney Journal, Vol. 14 Núm. 4 (january 2021) , p. 1055-1066
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14 p, 2.8 MB |
Endothelial damage and dysfunction in acute graft-versus-host disease
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Cordes, Steffen (Charité - Universitätsmedizin Berlin) ;
Mokhtari, Zeinab (Department of Medicine II. Würzburg University Hospital. Interdisciplinary Center for Clinical Research (IZKF). Laboratory for Experimental Stem Cell Transplantation) ;
Bartosova, Maria (Pediatric Nephrology. Center for Pediatric and Adolescent Medicine. University Hospital Heidelberg) ;
Mertlitz, Sarah (Charité - Universitätsmedizin Berlin) ;
Riesner, Katarina (Charité - Universitätsmedizin Berlin) ;
Shi, Yu (Charité - Universitätsmedizin Berlin) ;
Mengwasser, Jörg (Department of Surgery. Charité Universitätsmedizin Berlin) ;
Kalupa, Martina (Charité - Universitätsmedizin Berlin) ;
McGeary, Aleixandria (Charité - Universitätsmedizin Berlin) ;
Schleifenbaum, Johanna (Institute of Vegetative. Charité Universitätsmedizin Berlin) ;
Schrezenmeier, Jens (Charité - Universitätsmedizin Berlin) ;
Bullinger, Lars (Charité - Universitätsmedizin Berlin) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Beutel, Gernot (Hannover Medical School) ;
Schmitt, Claus Peter (Center for Child and Adolescent Medicine (Heidelberg, Alemanya)) ;
Beilhack, Andreas (Würzburg University Hospital) ;
Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Universitat Autònoma de Barcelona
Clinical studies have suggested a potential involvement of endothelial dysfunction and damage in the development and severity of acute graft-versus-host disease (aGvHD). Accordingly, we found an increased percentage of apoptotic caspase 3 positive blood vessels in duodenal and colonic mucosa biopsies of patients with severe aGvHD. [...]
2021 - 10.3324/haematol.2020.253716
Haematologica, Vol. 106 Núm. 8 (august 2021) , p. 2147-2160
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