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72.
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19 p, 533.1 KB |
Detection and quantification of the hypersensitive response cell death in Arabidopsis thaliana
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Salguero Linares, José (Centre de Recerca en Agrigenòmica) ;
Lema A., Saul (Universidad de las Américas (Ecuador)) ;
Salas Gómez, Marta (Centre de Recerca en Agrigenòmica) ;
Froilán Soares, Andrea (Centre de Recerca en Agrigenòmica) ;
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica)
In plants, the hypersensitive response (HR) is a programmed cell death modality that occurs upon recognition of harmful non-self. It occurs at the site of pathogen infection, thus preventing pathogens to live off plant tissue and proliferate. [...]
New York : Humana, 2022 -  10.1007/978-1-0716-2079-3_16
Plant Proteases and Plant Cell Death: Methods and protocols, 2022, p. 193-204
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73.
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14 p, 7.0 MB |
Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
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Zhang, Yuan (Tongji University School of Medicine) ;
Chen, Yuling (Fudan University) ;
Zhang, Zhao (Fudan University Shanghai Medical College) ;
Tao, Xiang (Fudan University) ;
Xu, Sha (Fudan University) ;
Zhang, Xinyan (Fudan University) ;
Zurashvili, Tinatin (David Tvildiani Medical University) ;
Lu, Zhouping (Tongji University School of Medicine) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Jin, Liping (Tongji University School of Medicine) ;
Zhao, Jianyuan (Xinhua Hospital School of Medicine) ;
Zhou, Xiangyu (Fudan University) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Acyl-CoA oxidase 2 (Acox2) is an enzyme involved in peroxisomal bile acid synthesis and branched-chain fatty acid degradation. Acox2 knockout (−/−) mice spontaneously developed liver cancer with marked lymphocytic infiltrate. [...]
2022 - 10.1038/s41419-022-04725-9
Cell death and disease, Vol. 13 (march 2022)
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74.
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15 p, 2.1 MB |
AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
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Roig-Soriano, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Griñán-Ferré, Christian (Universitat de Barcelona. Institut de Neurociències) ;
Espinosa-Parrilla, J. F. (Universitat Autònoma de Barcelona) ;
Abraham, Carmela R (Boston University School of Medicine) ;
Bosch i Merino, Assumpció (Instituto de Salud Carlos III) ;
Pallàs, Mercè (Universitat de Barcelona. Institut de Neurociències) ;
Chillón Rodríguez, Miguel (Institució Catalana de Recerca i Estudis Avançats)
Senescence represents a stage in life associated with elevated incidence of morbidity and increased risk of mortality due to the accumulation of molecular alterations and tissue dysfunction, promoting a decrease in the organism's protective systems. [...]
2022 - 10.1111/acel.13581
Aging Cell, Vol. 21 (march 2022)
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75.
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13 p, 4.2 MB |
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
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Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tarrés-Freixas, Ferran (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ortiz, Raquel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rovirosa, Carla (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodon, Jordi (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Vergara-Alert, Júlia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Segalés, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Guallar, Victor (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alfonso (Institució Catalana de Recerca i Estudis Avançats) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Mateu, Lourdes (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Chamorro, Anna (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Toledo, Ruth (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a prospective cohort of 332 patients with coronavirus disease 2019 (COVID-19) over more than a year after symptom onset. [...]
2022 - 10.1016/j.xcrm.2022.100523
Cell Reports Medicine, Vol. 3 (january 2022)
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76.
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12 p, 3.8 MB |
Modular Evolution and Population Variability of Oikopleura dioica Metallothioneins
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Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Cañestro, Cristian (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Chordate Oikopleura dioica probably is the fastest evolving metazoan reported so far, and thereby, a suitable system in which to explore the limits of evolutionary processes. For this reason, and in order to gain new insights on the evolution of protein modularity, we have investigated the organization, function and evolution of multi-modular metallothionein (MT) proteins in O. [...]
2021 - 10.3389/fcell.2021.702688
Frontiers in Cell and Developmental Biology, Vol. 9 (July 2021) , art. 702688
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77.
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78.
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19 p, 6.7 MB |
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
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Sanegre, Sabina (Department of Pathology, School of Medical, University of Valencia-INCLIVA) ;
Eritja, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
de Andrea, Carlos (Clínica Universidad de Navarra) ;
Diaz-Martin, Juan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Diaz-Lagares, Angel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Jácome, María Amalia (Universidade da Coruña) ;
Salguero-Aranda, Carmen (Hopital Universitario Virgen del Rocío) ;
García Ros, David (Clínica Universidad de Navarra) ;
Davidson, Ben (Norwegian Radium Hospital) ;
Lopez, Rafel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Melero, Ignacio (Clínica Universidad de Navarra) ;
Navarro, Samuel (Universitat de València) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
De Álava, Enrique (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Noguera, Rosa (Universitat de València) ;
Universitat Autònoma de Barcelona
The invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. [...]
2021 - 10.3389/fcell.2021.670185
Frontiers in Cell and Developmental Biology, Vol. 9 (june 2021)
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79.
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15 p, 8.5 MB |
Metabolite Profiling of Pig Seminal Plasma Identifies Potential Biomarkers for Sperm Resilience to Liquid Preservation
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Mateo-Otero, Yentel (Universitat de Girona. Departament de Biologia) ;
Fernández-López, Pol (Centre d'Estudis Avançats de Blanes) ;
Ribas-Maynou, Jordi (Universitat de Girona. Departament de Biologia) ;
Roca Aleu, Jordi (Universidad de Murcia. Departamento de Medicina y Cirugía Animal) ;
Miró, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Yeste Oliveras, Marc (Universitat de Girona. Departament de Biologia) ;
Barranco, Isabel (Department of Veterinary Medical Sciences)
Metabolomic approaches allow the study of downstream gene expression events since metabolites are considered as the products of cell signaling pathways. For this reason, many studies in humans have already been conducted to determine the influence of the metabolites present in seminal plasma (SP) on sperm physiology, and to identify putative biomarkers. [...]
2021 - 10.3389/fcell.2021.669974
Frontiers in Cell and Developmental Biology, Vol. 9 (may 2021)
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80.
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13 p, 1.3 MB |
Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9
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Garrigos, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Weninger, Astrid (Graz University of Technology) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Schmid, Christian (Graz University of Technology) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Rinnofner, Claudia (Austrian Centre of Industrial Biotechnology (ACIB)) ;
Glieder, Anton (Graz University of Technology) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome P450 enzymes (CYPs) of great biotechnological interest. Accelerating the drug development process by simple, quick and scalable access of human drug metabolites is key for efficient and targeted drug development in response to new and sometimes unexpected medical challenges and needs. [...]
2021 - 10.1186/s12934-021-01577-4
Microbial cell factories, Vol. 20 (April 2021) , art. 90
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81.
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12 p, 1.5 MB |
Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris
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Garrigos, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Vuoristo, Kiira (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Nieto-Taype, Miguel Angel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Tähtiharju, Juha (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Uusitalo, Jaana (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Tukiainen, Pauliina (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Schmid, Christian (Bisy GmbH, Wuenschendorf 292, 8200 Hofstaetten/Raab, Austria) ;
Tolstorukov, Ilya (Keck Graduate Institute) ;
Madden, Knut (Biogrammatics Inc, 2794 Loker Ave, West, Suite 103, Carlsbad, CA 92010 USA) ;
Penttilä, Merja (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Glieder, Anton (Bisy GmbH, Wuenschendorf 292, 8200 Hofstaetten/Raab, Austria) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (P), and the constitutive GAP promoter (P). [...]
2021 - 10.1186/s12934-021-01564-9
Microbial cell factories, Vol. 20 (march 2021)
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