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1.
8 p, 1.5 MB CD44-negative parietal-epithelial cell staining in minimal change disease : Association with clinical features, response to corticosteroids and kidney outcome / Roca, Neus (Universitat de Vic) ; Jatem, Elias (Hospital Universitari Arnau de Vilanova) ; Abo, Anabel (Institut de Recerca Biomèdica Dr Pifarré) ; Santacana, Maria (Institut de Recerca Biomèdica Dr Pifarré) ; Cruz, Alejandro (Hospital Universitari Vall d'Hebron) ; Madrid, Álvaro (Hospital Sant Joan de Dèu Barcelona) ; Fraga Rodríguez, Gloria María (Institut d'Investigació Biomèdica Sant Pau) ; Martin, Marisa (Hospital Universitari Arnau de Vilanova) ; Gonzalez, Jorge (Hospital Universitari Arnau de Vilanova) ; Martinez, Cristina (Institut de Recerca Biomèdica Dr Pifarré) ; Balius, Anna (Fundació Althaia de Manresa) ; Segarra, Alfons (Hospital Universitari Arnau de Vilanova) ; Universitat Autònoma de Barcelona
Activation of parietal-epithelial cells (PECs) with neo-expression of CD44 has been found to play a relevant role in the development of focal and segmental glomerulosclerosis (FSGS). The aim of this study was to analyse whether the expression of CD44 by PECs in biopsies of minimal change disease (MCD) is associated with the response to corticosteroids, with kidney outcomes and/or can be considered an early sign of FSGS. [...]
2022 - 10.1093/ckj/sfab215
Clinical Kidney Journal, Vol. 15 Núm. 3 (january 2022) , p. 545-552  
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2.
20 p, 15.9 MB Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase : Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in acute inflammation. Lipoxins are specialized pro-resolving mediators (SPMs), also formed from AA, that promote the resolution of acute inflammation. [...]
2024 - 10.1021/acscatal.3c04954
ACS catalysis, Vol. 14, Issue 2 (January 2024) , p. 637-656  
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3.
6 p, 168.1 KB Safety and effectiveness of ferric carboxymaltose intravenous therapy in pediatric patients with chronic kidney disease / Garcia-Ortega, Patricia (Hospital Universitari Vall d'Hebron) ; Jimenez-Lozano, Ines (Hospital Universitari Vall d'Hebron) ; Cruz, Alejandro (Hospital Universitari Vall d'Hebron) ; Polo, Aurora Fernandez (Hospital Universitari Vall d'Hebron) ; Lopez, Mercedes (Hospital Universitari Vall d'Hebron) ; Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Iron-deficiency anemia is the most common reason for worsening of the anemia characteristically seen in chronic kidney disease (CKD). Ferric carboxymaltose (FCM) is a macromolecular hydroxide ferric carbohydrate complex that allows high-dose iron to be administered parenterally for gradual, controlled release. [...]
2022 - 10.3389/fped.2022.967233
Frontiers in Pediatrics, Vol. 10 (october 2022)  
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4.
21 p, 4.8 MB Different Structures-Similar Effect : Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? / Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) ; Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Department of Biochemistry) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. [...]
2023 - 10.3390/molecules28145418
Molecules, Vol. 28, Issue 14 (July 2023) , art. 5418  
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5.
36 p, 1.2 MB Accounting for the instantaneous disorder in the enzyme-substrate Michaelis complex to calculate the Gibbs free energy barrier of an enzyme reaction / Romero Tellez, Sonia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Departament de Química)
Many enzyme reactions present instantaneous disorder. These dynamic fluctuations in the enzyme-substrate Michaelis complexes generate a wide range of energy barriers that cannot be experimentally observed, but that determine the measured kinetics of the reaction. [...]
2021 - 10.1039/d1cp01338f
Physical Chemistry Chemical Physics, Vol. 23 (June 2021) , p. 13042-13054  
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6.
277 p, 15.7 MB Simulaciones biomoleculares de algunas enzimas relevantes en procesos inflamatorios : 15-LOX, 5-LOX y COX-2. Aplicación al estudio de mecanismos y al diseño de inhibidores / Cruz Saez, Alejandro ; Lluch López, Josep Maria, dir. ; González-Lafont, Àngels, dir.
Les Lipoxigenases (LOXs) i Ciclooxigenases (COXs) són dues famílies d'enzims que inicien la biosíntesis de compostos lipídics de senyalització que són crucials per a la salut humana i estan implicats en un gran nombre de malalties. [...]
Las Lipoxigenasas (LOXs) y Ciclooxigenasas (COXs) son dos familias de enzimas que inician la biosíntesis de compuestos lipídicos de señalización que son cruciales para la salud humana y están implicados en un gran número de enfermedades. [...]
Lipoxygenases (LOXs) and Cyclooxygenases (COXs) are two families of enzymes which initiate the biosynthesis of lipid signalling compounds that are crucial for human health and are implicated in a number of diseases. [...]
2022  
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7.
29 p, 3.4 MB N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs : Mechanism of Action / Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Shafiullina, Rania (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Kakularam, Kumar R. (University Medicine Berlin. Department of Biochemistry, Charité) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (University Medicine Berlin. Department of Biochemistry, Charité) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Here, we describe the first systematic study on the mechanism of substrate-selective inhibition of mammalian ALOX15 orthologs. For this purpose, we prepared a series of N-substituted 5-(1H-indol-2-yl)anilines and found that (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates and their monofluorinated analogues are potent and selective inhibitors of the linoleate oxygenase activity of rabbit and human ALOX15. [...]
2022 - 10.1021/acs.jmedchem.1c01563
Journal of Medicinal Chemistry, Vol. 65, Issue 3 (February 2022) , p. 1979-1995  
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8.
18 p, 31.6 MB Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15 / Ivanov, Igor (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Zhuravlev, Alexander (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Di Venere, Almerinda (University of Tor Vergata. Department of Experimental Medicine) ; Nicolai, Eleonora (University of Tor Vergata. Department of Experimental Medicine) ; Stehling, Sabine (Charite-University Medicine Berlin. Institute of Biochemistry) ; Osca Lluch, José María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Institute of Biochemistry)
Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. [...]
2021 - 10.3390/ijms22063285
International journal of molecular sciences, Vol. 22, Issue 6 (March 2021) , art. 3285  
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9.
7 p, 397.2 KB Linear Growth in Pediatric Kidney Transplant Population / Lopez-Gonzalez, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Munoz, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Perez-Beltran, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cruz, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gander, Romy (Hospital Universitari Vall d'Hebron) ; Ariceta Iraola, Gema (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Introduction: Growth retardation is one of the main complications of chronic kidney disease (CKD) in children and induces a negative impact on quality of life. Materials and Methods: Retrospective analysis of all consecutive patients younger than 18 years old who received a first KT in our center between 2008 and 2018. [...]
2020 - 10.3389/fped.2020.569616
Frontiers in Pediatrics, Vol. 8 (december 2020)  
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10.
2 p, 518.8 KB Rol del residu Gln596 en el funcionament d'ALOX15, un enzim crucial per a la salut / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Actualment se sap que malalties com l'arterioesclerosi o l'osteoporosi estan directament relacionades amb l'activitat de l'enzim ALOX15. Un estudi realitzat pel grup de recerca de l'àrea de Física-Química del Departament de Química de la UAB ha observat en diversos experiments l'important paper del residu Gln596 per a l'estabilitat d'aquest enzim, molt important per a controlar el desenvolupament d'aquesta mena d'afeccions.
Actualmente se sabe que enfermedades como la arterioesclerosis o la osteoporosis están relacionadas con la actividad de la enzima ALOX15. Un estudio realizado por el grupo de investigación del área de Física-Química del Departamento de Química de la UAB ha observado en varios experimentos el papel del residuo Gln596 para la estabilidad de dicha enzima, muy importante para controlar el desarrollo de este tipo de afecciones.
2020
UAB divulga, Desembre 2020
2 documents
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