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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna C. ;
Damrauer, Scott M. ;
de Vries, Paul S. ;
Smith, Nicholas L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 -  10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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19 p, 4.3 MB |
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses
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Martos-Folgado, Inmaculada (Medical Department. Pfizer S.L.U.) ;
del Monte-Monge, Alberto (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Lorenzo, Cristina (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Busse, Christian E. (Division of B Cell Immunology. German Cancer Research Center) ;
Delgado, Pilar (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Mur, Sonia M. (Centro Nacional de Investigaciones Cardiovasculares. Lymphocyte Biology Lab) ;
Cobos-Figueroa, Laura (Grupo de Manufactura Avanzada con Láser del Centro Láser. Universidad Politécnica de Madrid) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Martín-Ventura, Jose L. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Wardemann, Hedda (Division of B Cell Immunology. German Cancer Research Center) ;
Ramiro, Almudena R. (Lymphocyte Biology Lab. Centro Nacional de Investigaciones Cardiovasculares (CNIC))
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. [...]
2022 - 10.1016/j.celrep.2022.111468
Cell reports, Vol. 41 Núm. 2 (november 2022) , p. 111468
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32 p, 9.6 MB |
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
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Duperron, Marie-Gabrielle (Bordeaux University Hospital(França)) ;
Knol, Maria J. (Erasmus MC University Medical Center) ;
Le Grand, Quentin (Bordeaux Population Health Research Center) ;
Evans, Tavia E. (Erasmus MC University Medical Center) ;
Mishra, Aniket (University of Bordeaux) ;
Tsuchida, Ami (University of Bordeaux) ;
Roshchupkin, Gennady V (Erasmus MC University Medical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine) ;
Trégouët, David-Alexandre (University of Bordeaux) ;
Romero, Jose Rafael (The Framingham Heart Study) ;
Frenzel, Stefan (University Medicine Greifswald) ;
Luciano, Michelle (University of Edinburgh) ;
Hofer, Edith (Medical University of Graz) ;
Bourgey, Mathieu (McGill University) ;
Dueker, Nicole D. (University of Miami) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hilal, Saima (National University of Singapore and National University Health System) ;
Tankard, Rick M. (Curtin University) ;
Dubost, Florian (Erasmus MC University Medical Center) ;
Shin, Jean (University of Toronto) ;
Saba, Yasaman (Medical University of Graz) ;
Armstrong, Nicola (Curtin University) ;
Bordes, Constance (Bordeaux Population Health Research Center) ;
Bastin, Mark E. (University of Edinburgh) ;
Beiser, Alexa (Boston University School of Public Health) ;
Brodaty, Henry (Dementia Collaborative Research Centre Assessment and Better Care) ;
Bülow, Robin (University Medicine Greifswald) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Christopher (National University of Singapore) ;
Cheng, Ching-Yu (Duke-NUS Medical School) ;
Deary, Ian J. (University of Edinburgh) ;
Gampawar, Piyush G. (Medical University of Graz) ;
Himali, Jayandra J. (UT Health San Antonio) ;
Jiang, Jiyang (University of New South Wales) ;
Kawaguchi, Takahisa (Kyoto University Graduate School of Medicine) ;
Li, Shuo (Boston University School of Public Health) ;
Macalli, Melissa (University of Bordeaux) ;
Marquis, Pascale (McGill University) ;
Morris, Zoe (Royal Infirmary of Edinburgh) ;
Muñoz Maniega, Susana (UK Dementia Research Institute Centre at the University of Edinburgh) ;
Miyamoto, Susumu (Kyoto University Hospital) ;
Okawa, Masakazu (Kyoto University Graduate School of Medicine) ;
Paradise, Matthew (University of New South Wales) ;
Parva, Pedram (Harvard Medical School) ;
Rundek, Tatjana (University of Miami) ;
Sargurupremraj, Muralidharan (University of Bordeaux) ;
Schilling, Sabrina (University of Bordeaux) ;
Setoh, Kazuya (Shizuoka Graduate University of Public Health) ;
Soukarieh, Omar (University of Bordeaux) ;
Tabara, Yasuharu (Shizuoka Graduate University of Public Health) ;
Teumer, Alexander (University Medicine Greifswald) ;
Thalamuthu, Anbupalam (University of New South Wales) ;
Trollor, Julian (UNSW) ;
Valdés Hernández, Maria C. (University of Edinburgh) ;
Vernooij, Meike W. (Erasmus MC University Medical Center) ;
Völker, Uwe (University Medicine Greifswald) ;
Wittfeld, Katharina (German Center for Neurodegenerative Diseases) ;
Wong, Tien Yin (Tsinghua University) ;
Wright, Margaret J. (University of Queensland) ;
Zhang, Junyi (Peking Union Medical College Hospital) ;
Zhao, Wanting (Duke-NUS Medical School) ;
Zhu, Yi-Cheng (Peking Union Medical College Hospital) ;
Schmidt, Helena (Medical University of Graz) ;
Sachdev, Perminder S. (Prince of Wales Hospital (Australia)) ;
Wen, Wei (University of New South Wales) ;
Yoshida, Kazumichi (Kyoto University Graduate School of Medicine) ;
Joutel, Anne (Université Paris Cité) ;
Satizabal, Claudia L. (UT Health San Antonio) ;
Sacco, Ralph L. (University of Miami) ;
Bourque, Guillaume (McGill University) ;
Lathrop, Mark (Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University) ;
Paus, Tomas (University of Toronto) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Yang, Qiong (Boston University School of Public Health) ;
Mazoyer, Bernard (Bordeaux University Hospital (França)) ;
Boutinaud, Philippe (Fealinx) ;
Okada, Yukinori (University of Tokyo) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases) ;
Mather, Karen A (Neuroscience Research Australia) ;
Schmidt, Reinhold (Medical University of Graz) ;
Joliot, Marc (University of Bordeaux) ;
Ikram, M. Arfan (Erasmus MC University Medical Center) ;
Matsuda, Fumihiko (Kyoto University Graduate School of Medicine) ;
Tzourio, Christophe (Bordeaux University Hospital(França)) ;
Wardlaw, Joanna (University of Edinburgh) ;
Seshadri, Sudha (UT Health San Antonio) ;
Adams, Hieab (Universidad Adolfo Ibáñez) ;
Debette, Stéphanie (Bordeaux University Hospital(França)) ;
Universitat Autònoma de Barcelona
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66. [...]
2023 - 10.1038/s41591-023-02268-w
Nature Medicine, Vol. 29 (april 2023) , p. 950-962
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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12 p, 1.1 MB |
A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype
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Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Freijo, Marimar (Biocruces-Bizkaia Health Research Institute. Department of Neurology) ;
Arenillas, Juan F (Hospital Universitario de Valladolid) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ;
Ribó, Marc (Hospital Universitari Vall d'Hebron) ;
Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Roquer, Jaume (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz-Narbona, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Cancio, Elena (Hospital Central de Asturias (HUCA)) ;
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Diaz-Navarro, Rosa (Institut d'Investigació Sanitària Illes Balears) ;
Vives-Bauza, Cristòfol (Institut d'Investigació Sanitària Illes Balears) ;
Serrano-Heras, Gemma (Complejo Hospitalario Universitario de Albacete) ;
Segura, Tomás (Complejo Hospitalario Universitario de Albacete) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dhar, Rajat (Washington University School of Medicine. Department of Neurology.) ;
Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Blay, Natalia (Institut Germans Trias i Pujol) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cruchaga, Carlos (Washington University in St. Louis. Neurogenomics and Informatics Center.) ;
Lee, Jim-Moo (Washington University School of Medicine. Department of Neurology.) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. [...]
2022 - 10.3389/fcvm.2022.940696
Frontiers in Cardiovascular Medicine, Vol. 9 (august 2022) , p. 940696
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13 p, 1.4 MB |
Compliance to Multidisciplinary Lifestyle Intervention Decreases Blood Pressure in Patients with Resistant Hypertension : A Cross-Sectional Pilot Study
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Espinel Garuz, Eugenia (Hospital Universitari Vall d'Hebron) ;
Azancot, María A (Hospital Universitari Vall d'Hebron) ;
Gomez-Garrido, Alba (Hospital Universitari Vall d'Hebron) ;
Beneria, Anna (Hospital Universitari Vall d'Hebron) ;
Caraben, Anna (Hospital Universitari Vall d'Hebron) ;
Andurell, Laura (Hospital Universitari Vall d'Hebron) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ;
Castañé, Helena (Universitat Rovira i Virgili) ;
Joven, Jorge (Universitat Rovira i Virgili) ;
Seron, Daniel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Hypertension is a common chronic medical condition. Treatment is not satisfactory in a significant proportion of patients with primary hypertension, despite the concurrent use of three or more medications with different mechanisms of action. [...]
2023 - 10.3390/jcm12020679
Journal of clinical medicine, Vol. 12 (january 2023)
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7.
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10 p, 2.3 MB |
New candidate blood biomarkers potentially associated with white matter hyperintensities progression
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Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riba-Llena, Iolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palà, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50-70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. [...]
2021 - 10.1038/s41598-021-93498-w
Scientific reports, Vol. 11 (july 2021)
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8.
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7 p, 903.0 KB |
Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients
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Forés Raurell, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Manresa, J. M (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
López-Lifante, Victor M. (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Heras, Antonio (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez, Xose (Hospital Municipal de Badalona) ;
Ruiz, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alzamora, M. Teresa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Torán Montserrat, Pere (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
Objective: The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study. [...]
2021 - 10.3390/diagnostics11060937
Diagnostics, Vol. 11 (may 2021)
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9.
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14 p, 632.5 KB |
Diabetes, Albuminuria and the Kidney-Brain Axis
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Ariton, Diana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Cognitive decline and kidney disease are significant public health problems that share similar characteristics and risk factors. The pathophysiology of the kidney-brain axis is not completely understood, and studies analysing the relationship between the biomarkers of kidney damage and cognitive impairment show different results. [...]
2021 - 10.3390/jcm10112364
Journal of clinical medicine, Vol. 10 (may 2021)
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10.
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15 p, 1.0 MB |
Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
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Marazuela, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Luna, David (Hospital Universitari Vall d'Hebron) ;
Vert, Carla (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Martínez-Zabaleta, Maite (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arenillas, Juan F.. (Universidad de Valladolid) ;
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Montaner, Joan (Universidad de Sevilla) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. [...]
2021 - 10.3390/jcm10050989
Journal of clinical medicine, Vol. 10 (march 2021)
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