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7 p, 638.1 KB |
Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder
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Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanvisens, Arantza (Girona Biomedical Research Institute. Clinical Pharmacology Department) ;
Barbier-Torres, Lucía (Cedars-Sinai Medical Center) ;
Blanes, Rafael (Hospital Universitari Son Dureta (Palma de Mallorca, Balears)) ;
Miquel, Laia (Universitat de Barcelona) ;
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rubio, Gabriel (Universidad Complutense de Madrid) ;
Bolao, Ferran (Universitat de Barcelona) ;
Zuluaga Cruz, Andrea Paola (Clinical Pharmacology Department) ;
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez de Fonseca, Fernando (Instituto de Investigación Biomédica de Málaga) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. [...]
2023 -  10.1016/j.drugalcdep.2023.109822
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28 p, 430.7 KB |
Drug-related deaths in hospital inpatients : A retrospective cohort study
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Montané, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Arellano, Ana Lucía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Sanz, Yolanda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roca, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farré, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Aims: To determine the incidence of drug-related deaths (DRD) in a university hospital in 2015, to describe their characteristics, and to discover risk factors of DRD. Methods: An analytic and retrospective cohort study. [...]
2018 - 10.1111/bcp.13471
British Journal of Clinical Pharmacology, Vol. 84 Núm. 3 (march 2018) , p. 542-552
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15 p, 286.2 KB |
Drug-related deaths in a tertiary hospital : Characteristics of spontaneously reported cases and comparison to cases detected from a retrospective study
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Arellano, Ana Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alcubilla, Pau (Hospital Clínic i Provincial de Barcelona) ;
Farré, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Montané, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Drug-related deaths (DRDs) are a common cause of hospital death. Pharmacovigilance, either as spontaneous reporting or active surveillance, plays a key role in the detection and reporting of suspected adverse drug reactions (ADRs). [...]
2021 - 10.3390/jcm10184053
Journal of clinical medicine, Vol. 10 Núm. 18 (september 2021) , p. 4053
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11 p, 517.0 KB |
Restorative Retelling for Processing Psychedelic Experiences : Rationale and Case Study of Complicated Grief
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González, Débora (International Center for Ethnobotanical Education, Research and Services (ICEERS)) ;
Aixalà, Marc B. (International Center for Ethnobotanical Education, Research and Services (ICEERS)) ;
Neimeyer, Robert A. (Portland Institute for Loss and Transition) ;
Cantillo, Jordi (International Center for Ethnobotanical Education, Research and Services (ICEERS)) ;
Nicolson, Donald (Bath Spa University) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Many psychedelic experiences are meaningful, but ineffable. Engaging in meaning-making regarding emerging symbolic content and changing previous schemas have been proposed as mechanisms of change in psychedelic therapy. [...]
2022 - 10.3389/fpsyg.2022.832879
Frontiers in psychology, Vol. 13 (may 2022)
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5.
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5 p, 154.0 KB |
Synthetic cannabinoids use in a sample of opioid-use disorder patients
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Alías Ferri, María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pellegrini, Manuela (National Centre on Istituto Superiore di Sanità (Itàlia)) ;
Marchei, Emilia (Istituto Superiore di Sanità (Itàlia)) ;
Pacifici, Roberta (Istituto Superiore di Sanità (Itàlia)) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità (Itàlia)) ;
Pichini, Simona (National Istituto Superiore di Sanità (Itàlia)) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fonseca, Francina 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Cannabis is the most widely consumed illegal drug in the world and synthetic cannabinoids are increasingly gaining popularity and replacing traditional cannabis. These substances are a type of new psychoactive substance that mimics the cannabis effects but often are more severe. [...]
2022 - 10.3389/fpsyt.2022.956120
Frontiers in psychiatry, Vol. 13 (august 2022)
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19 p, 2.3 MB |
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
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Requena-Ocaña, Nerea (Universidad Complutense de Madrid. Departamento de Psicobiología) ;
Flores-Lopez, María (Hospital Regional Universitario de Málaga) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
García-Marchena, Nuria (Institut Germans Trias i Pujol) ;
Ruiz, Juan Jesús (Centro Provincial de Drogodependencias (CPD) de Málaga) ;
Ortega-Pinazo, Jesús (Hospital Regional Universitario de Málaga) ;
Serrano, Antonia (Hospital Regional Universitario de Málaga) ;
Pavón-Morón, Francisco Javier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Suarez, Juan (Department of Anatomy, Legal Medicine and History of Science, School of Medicine, University of Malaga) ;
Rodríguez de Fonseca, Fernando (Hospital Regional Universitario de Málaga) ;
Araos, Pedro (Universidad de Málaga. Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento)
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. [...]
2022 - 10.3390/biomedicines10050947
Biomedicines, Vol. 10 (april 2022)
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15 p, 1.9 MB |
GC-MS/MS Determination of Synthetic Cathinones : 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study
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Nuñez-Montero, Melani (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lombroni, Claudia (Univesità degli Studi di Torino) ;
Maida, Nunzia La (Istituto Superiore di Sanità) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marchei, Emilia (Istituto Superiore di Sanità) ;
Universitat Autònoma de Barcelona
This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. [...]
2023 - 10.3390/ijms24119387
International journal of molecular sciences, Vol. 24 (may 2023)
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13 p, 819.4 KB |
Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Berardinelli, Diletta (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Malaca, Sara (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Huestis, Marilyn A. (Thomas Jefferson University) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50-200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. [...]
2022 - 10.3390/ijms232314636
International journal of molecular sciences, Vol. 23 (november 2022)
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9 p, 771.4 KB |
Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans
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Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Istituto Superiore di Sanità) ;
Varì, Maria Rosaria (Instituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Zaami, Simona (Università La Sapienza) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. [...]
2023 - 10.3390/ijms24087395
International journal of molecular sciences, Vol. 24 (april 2023)
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10.
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12 p, 1.5 MB |
Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites : Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH
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Sprega, Giorgia (Università Politecnica delle Marche) ;
Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tini, Anastasio (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers participated after ingestion of 50, 100, 150 and 200 mg of methylone. [...]
2023 - 10.3390/metabo13040468
Metabolites, Vol. 13 (march 2023)
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