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1.
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9 p, 1.1 MB |
Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer
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Pons, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-León, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Altaleb, Ahmad (Mubarak Al-Kabeer Hospital, Jabriya, Kuwait) ;
Ussene, Esperança (Hospital Vila Franca de Xira, Portugal) ;
Iglesias, Roman (Hospital Santa Barbara, Ciudad Real) ;
Castillo, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castellà Fernández, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cirauqui, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Pedro Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Digital counting methods were developed to decrease the high intra- and inter-observer variability of immunohistochemical markers such as Ki67, with most presenting a good correlation coefficient (CC). [...]
2022 -  10.1038/s41598-022-11411-5
Scientific reports, Vol. 12 (may 2022)
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2.
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18 p, 6.6 MB |
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation
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Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gohr, André (Max Planck Institute of Molecular Cell Biology and Genetics) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute to the clearing of HIV reservoir. [...]
2022 - 10.3389/fimmu.2022.1001068
Frontiers in immunology, Vol. 13 (september 2022)
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3.
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17 p, 1.4 MB |
Immune Response and Effects of COVID-19 Vaccination in Patients with Lung Cancer-COVID Lung Vaccine Study
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Hernandez, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boigues Pons, Marc (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Notario, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pous, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torres, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benitez, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Moran, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina)
During the SARS-CoV-2 pandemic, lung cancer patients have been considered an especially vulnerable population and have been prioritized for vaccination. However, several aspects (degree of immunity, potential interaction with active anticancer therapy, safety, and tolerability of the vaccines) remained unclear. [...]
2022 - 10.3390/cancers15010137
Cancers, Vol. 15, Num. 1 (January 2022) , art. 137
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4.
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10 p, 3.7 MB |
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
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Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Felip, Eudald (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bernat-Peguera, Adrià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase which has been proposed as a putative prognostic factor in haematological cancers and certain solid tumours, although with controversial data. [...]
2023 - 10.3389/fimmu.2023.1112761
Frontiers in immunology, Vol. 14 (february 2023)
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5.
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16 p, 2.7 MB |
Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer
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Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Brasó-Maristany, Fara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez-Sáez, Olga (Universitat de Barcelona) ;
Sanfeliu, Esther (Hospital Clínic i Provincial de Barcelona) ;
Bellet Ezquerra, Meritxell (Vall d'Hebron Institut d'Oncologia) ;
Galván, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez, Débora (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pascual, Tomás (University of North Carolina) ;
Marín-Aguilera, Mercedes (Reveal Genomics (Barcelona)) ;
Rodríguez, Anna (Hospital Clínic i Provincial de Barcelona) ;
Chic, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Adamo, Barbara (Universitat de Barcelona) ;
Paré Brunet, Laia (Reveal Genomics (Barcelona)) ;
Vidal Losada, Maria (Universitat de Barcelona) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez-Rey, Marina (Vall d'Hebron Institut d'Oncologia) ;
Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matito, Judit (Vall d'Hebron Institut d'Oncologia) ;
Sánchez-Bayona, Rodrigo (Hospital Universitario 12 de Octubre (Madrid)) ;
Suñol, Anna (Vall d'Hebron Institut d'Oncologia) ;
Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Ciruelos, Eva (Hospital Universitario 12 de Octubre (Madrid)) ;
Tolosa, Pablo (Hospital Universitario 12 de Octubre (Madrid)) ;
Muñoz, Montserrat (SOLTI cooperative group (Barcelona)) ;
González-Farré, Blanca (Hospital Clínic i Provincial de Barcelona) ;
Villagrasa, Patricia (Reveal Genomics (Barcelona)) ;
Parker, Joel S. (University of North Carolina) ;
Perou, Charles M. (University of North Carolina) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Liquid biopsy has proven valuable in identifying individual genetic alterations; however, the ability of plasma ctDNA to capture complex tumor phenotypes with clinical value is unknown. To address this question, we have performed 0. [...]
2023 - 10.1038/s41467-023-36801-9
Nature communications, Vol. 14 (march 2023)
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6.
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11 p, 1.6 MB |
Pharmacological Inhibition of IKK to Tackle Latency and Hyperinflammation in Chronic HIV-1 Infection
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Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Garcia-Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Calba, Ignasi (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sirera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
HIV latent infection may be associated with disrupted viral RNA sensing, interferon (IFN) signaling, and/or IFN stimulating genes (ISG) activation. Here, we evaluated the use of compounds selectively targeting at the inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex subunits and related kinases (TBK1) as a novel pathway to reverse HIV-1 latency in latently infected non-clonal lymphoid and myeloid cell in vitro models. [...]
2022 - 10.3390/ijms232315000
International journal of molecular sciences, Vol. 23 Núm. 23 (november 2022) , p. 15000
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7.
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23 p, 904.8 KB |
Targeted Therapeutic Options and Future Perspectives for HER2-Positive Breast Cancer
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Ferrando-díez, Angelica (Institut Germans Trias i Pujol) ;
Felip, Eudald (Institut Germans Trias i Pujol) ;
Felip, Enriqueta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pous, Anna (Institut Germans Trias i Pujol) ;
Sirven, Milana Bergamino (Institut Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Despite the improvement achieved by the introduction of HER2-targeted therapy, up to 25% of early human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients will relapse. Beyond trastuzumab, other agents approved for early HER2+ BC include the monoclonal antibody pertuzumab, the antibody-drug conjugate (ADC) trastuzumab-emtansine (T- DM1) and the reversible HER2 inhibitor lapatinib. [...]
2022 - 10.3390/cancers14143305
Cancers, Vol. 14 Núm. 14 (7-2 2022) , p. 3305
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8.
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20 p, 1.9 MB |
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types
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Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez, Maica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Romeo, Margarita (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Morán, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Layos, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez-Roca, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Pedro Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ample evidence exists connecting dNTP pool dysregulation to cancer and genomic instability. SAMHD1, the unique dNTP triphosphohydrolase described in humans, has been proposed to play a key role in hematological cancers, although its value in advanced solid tumors has not yet been explored. [...]
2022 - 10.20944/preprints202201.0141.v1
Cancers, Vol. 14 Núm. 3 (january 2022)
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9.
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2 p, 201.0 KB |
Erratum : Castellví, M. et al. Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy. Cancers 2020, 12, 713
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Castellví, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Este, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
2020 - 10.3390/cancers12071728
Cancers, Vol. 12 (june 2020)
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