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15 p, 5.1 MB |
Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia
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Hernández Martín, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Redondo-Castro, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López Vales, Rubén (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Research on microglia has established the differentiation between the so-called M1 and M2 phenotypes. However, new frameworks have been proposed attempting to discern between meaningful microglia profiles. [...]
2021 -  10.3389/fnmol.2021.582497
Frontiers in molecular neuroscience, Vol. 14 (May 2021) , art. 582497
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18 p, 1.7 MB |
MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments
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Martins, Pedro M. (Universidade do Porto. Instituto de Ciências Biomédicas Abel Salazar) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Silva, Alexandra (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Pinto, Maria F. (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Sárkány, Zsuzsa (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Figueiredo, Francisco (Universidade do Porto. Instituto de Ciências Biomédicas Abel Salazar) ;
Barbosa Pereira, Pedro José (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bednarikova, Zuzana (Slovak Academy of Sciences. Department of Biophysics) ;
Burdukiewicz, Michal (Warsaw University of Technology. Faculty of Mathematics and Information Science) ;
Galzitskaya, Oxxana V. (Russian Academy of Sciences. Institute of Theoretical and Experimental Biophysics) ;
Gazova, Zuzana (Slovak Academy of Sciences. Department of Biophysics) ;
Gomes, Cláudio M. (Universidade de Lisboa. Departamento de Química e Bioquímica) ;
Pastore, Annalisa (King's College London. Maurice Wohl Clinical Neuroscience Institute) ;
Serpell, Louise C. (University of Sussex. School of Life Sciences) ;
Skrabana, Rostislav (Slovak Academy of Sciences. Institute of Neuroimmunology) ;
Smirnovas, Vytautas (Vilnius University. Institute of Biotechnology) ;
Ziaunys, Mantas (Vilnius University. Institute of Biotechnology) ;
Otzen, Daniel E. (Aarhus University. Department of Molecular Biology and Genetics) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Macedo-Ribeiro, Sandra (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. [...]
2020 - 10.3389/fnmol.2020.582488
Frontiers in molecular neuroscience, Vol. 13 (November 2020) , art. 582488
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14 p, 4.3 MB |
N -Methyl--Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP Mice
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Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Reyes Resina, Irene (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Canela, Enric I. (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Lillo Jové, Jaume (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Tarutani, Airi (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ;
Hasegawa, Masato (Tokyo Metropolitan Institute of Medical Science. Department of Dementia and Higher Brain Function) ;
del Ser Badia, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
del Rio, José A. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Kreutz, Michael R. (University Medical Center Hamburg-Eppendorf) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
N -methyl--aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade. Both MAPK- and Ca 2+ -mediated events are important for both neurotransmission and neural cell function and fate. [...]
2018 - 10.3389/fnmol.2018.00273
Frontiers in molecular neuroscience, Vol. 11 (August 2018) , art. 273
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12 p, 3.6 MB |
ZPD-2, a small compound that inhibits α-synuclein amyloid aggregation and its seeded polymerization
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Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conde Giménez, María (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ;
Carija, Anita (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Dalfo, Esther (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
García, Jesús (Institut de Recerca Biomèdica de Lleida) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Salvatella, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Sancho, Javier (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
α-Synuclein (α-Syn) forms toxic intracellular protein inclusions and transmissible amyloid structures in Parkinson's disease (PD). Preventing α-Syn self-assembly has become one of the most promising approaches in the search for disease-modifying treatments for this neurodegenerative disorder. [...]
2019 - 10.3389/fnmol.2019.00306
Frontiers in molecular neuroscience, Vol. 12 (Dec. 2019) , art. 306
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10 p, 3.4 MB |
Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy
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Oliván, Sara (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Calvo, Ana Cristina (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ;
Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ;
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Manzano Martínez, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ;
Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón) ;
Tizzano, Eduardo F. (Hospital Universitari Vall d'Hebron) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Osta, Rosario (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in molecular neuroscience, Vol. 9 (August 2016) , art. 76
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18 p, 3.4 MB |
Learning improvement after PI3K activation correlates with de novo formation of functional small spines
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Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ;
Domínguez Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ;
Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ;
Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ;
Sandi, Carmen (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute) ;
Fernández-Ruiz, Antonio (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Martín-Vázquez, Gonzalo (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Herreras, Oscar (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in molecular neuroscience, Vol. 6 (January 2014) , art. 54
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8 p, 2.2 MB |
Loss of mitochondrial Ndufs4 in striatal medium spiny neurons mediates progressive motor impairment in a mouse model of leigh syndrome
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Chen, Byron (University of Washington. Howard Hughes Medical Institute) ;
Hui, Jessica (Seattle Children's Research Institute (Seattle, Estats Units d'Amèrica)) ;
Montgomery, Kelsey S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. [...]
2017 - 10.3389/fnmol.2017.00265
Frontiers in molecular neuroscience, Vol. 10 (August 2017) , article 265
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