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15 p, 910.6 KB |
Recreational Drug Use in People Living with HIV in Spain : Factors Associated with Drug Use and the Impact on Clinical Outcomes
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Castro, Vanessa (Hospital Marina Baixa (La Vila Joiosa, Alacant)) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Jaén, Ángeles (Universitat de Barcelona) ;
Casado, José Luis (Hospital Universitario Ramón y Cajal (Madrid)) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
Cenoz, Santiago (ViiV Healthcare) ;
Fuster-RuizdeApodaca, María José (Universidad Nacional de Educación a Distancia (Espanya))
We analysed the impact of recreational drug use (RDU) on different outcomes in people living with HIV (PLHIV). A multicentre retrospective cohort study was performed with two cohorts of PLHIV included: people using recreational drugs (PURD) vs. [...]
2021 -  10.1007/s10461-021-03271-3
AIDS and Behavior, Vol. 25 (may 2021) , p. 3883-3897
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12.
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15 p, 1.8 MB |
L-ferritin : One gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia-report of new cases
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Cadenas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fita-Torró, Josep (BloodGenetics SL. Esplugues de Llobregat) ;
Bermúdez-Cortés, Mar (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Hernandez-Rodriguez, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, José Luis (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Llinares, María Esther (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Galera, Ana (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Romero, Julia Lee (Biomedical Engineering Department. University of Texas at Austin) ;
Pérez-Montero, Santiago (BloodGenetics SL. Esplugues de Llobregat) ;
Tornador, Cristian (BloodGenetics SL. Esplugues de Llobregat) ;
Sánchez-Fernández, Mayka (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following five diseases: (1) hereditary hyperferritinemia with cataract syndrome (HHCS), (2) neuroferritinopathy, a subtype of neurodegeneration with brain iron accumulation (NBIA), (3) benign hyperferritinemia, (4) L-ferritin deficiency with autosomal dominant inheritance, and (5) L-ferritin deficiency with autosomal recessive inheritance. [...]
2019 - 10.3390/ph12010017
Pharmaceuticals, Vol. 12 Núm. 1 (2019) , p. 17
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13 p, 3.4 MB |
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia
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López-Millán, Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanchéz-Martínez, Diego (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Ballerini, Paola (Pediatric Hematology. Armand Trousseau Hospital) ;
Suessbier, U. (University Hospital Zurich (Suïssa)) ;
Nombela-Arrieta, Cesar (University Hospital Zurich (Suïssa)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, with cure rates of ∼80%. MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness and early relapse, and therefore new therapeutic targets are needed for relapsed/refractory MLLr-B-ALL. [...]
2019 - 10.1038/s41375-018-0353-0
Leukemia, Vol. 33 Núm. 7 (january 2019) , p. 1557-1569
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14.
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13 p, 5.4 MB |
Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity
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Zanetti, S. R. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Querol, Sergi (Blood and Tissue Bank) ;
Delgado, M. (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Background Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell acute lymphoblastic leukemia (B-ALL), relapse is common. [...]
2020 - 10.1136/jitc-2020-001419
Journal for immunotherapy of cancer, Vol. 8 Núm. 2 (31 2020) , p. e001419
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15.
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11 p, 5.7 MB |
Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope
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Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, S. R. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez-Martínez, D. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Baroni, Matteo Libero (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster, José Luis (Sección de Oncohematología Pediátrica. Hosp. Clin. Universitario Virgen de la Arrixaca and Instituto Murciano de Investigacion Biosanitaria) ;
Ballerini, Paola (Department of Pediatric Hemato-oncology. Armand-Trousseau Childrens Hospital) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Fuentes, Narcís (Universitat de Vic - Universitat Central de Catalunya) ;
Engel, P. (Universitat de Barcelona. Departament de Biomedicina) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Background There are few therapeutic options available for patients with B-cell acute lymphoblastic leukemia (B-ALL) relapsing as CD19 - either after chemotherapy or CD19-targeted immunotherapies. CD22-chimeric antigen receptor (CAR) T cells represent an attractive addition to CD19-CAR T cell therapy because they will target both CD22 + CD19 - B-ALL relapses and CD19 - preleukemic cells. [...]
2020 - 10.1136/jitc-2020-000896
Journal for immunotherapy of cancer, Vol. 8 Núm. 2 (november 2020) , p. e000896
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13 p, 1.8 MB |
Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse
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Forero-Castro, Maribel (Universidad Pedagógica y Tecnológica de Colombia) ;
Montaño, Adrián (Universidad de Salamanca) ;
Robledo, Cristina (Universidad de Salamanca) ;
García de Coca, Alfonso (Hospital Clínico Universitario de Valladolid) ;
Fuster, José Luis (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
De las Heras, Natalia (Hospital Virgen Blanca (León)) ;
Queizán, José Antonio (Hospital General de Segovia) ;
Hernández-Sánchez, María (Universidad de Salamanca) ;
Corchete Sánchez, Luis Antonio (Hospital Universitario de Salamanca) ;
Martín-Izquierdo, Marta (Universidad de Salamanca) ;
Ribera Salas, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Benito, Rocío (Universidad de Salamanca) ;
Hernández Rivas, Jesús María (Hospital Universitario de Salamanca)
The clonal basis of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is complex and not fully understood. Next-generation sequencing (NGS), array comparative genomic hybridization (aCGH), and multiplex ligation-dependent probe amplification (MLPA) were carried out in matched diagnosis-relapse samples from 13 BCP-ALL patients to identify patterns of genetic evolution that could account for the phenotypic changes associated with disease relapse. [...]
2020 - 10.3390/diagnostics10070455
Diagnostics, Vol. 10 (july 2020)
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18 p, 1.2 MB |
Prevalence and patterns of illicit drug use in people living with HIV in Spain : a cross-sectional study
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Fuster-RuizdeApodaca, María José (Sociedad Española Interdisciplinaria del Sida-SEISIDA) ;
Castro, Vanessa (Hospital Marina Baixa (La Vila Joiosa, Alacant)) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Laguía, Ana (Universidad Nacional de Educación a Distancia (Espanya). Departamento de Psicología Social y de las Organizaciones) ;
Jaén, Ángeles (Mútua de Terrassa) ;
Iniesta, Carlos (Instituto de Salud Carlos III) ;
Cenoz, Santiago (Medical Department. ViiV Healthcare) ;
Galindo, María José (Hospital Clínic Universitari (València)) ;
Universitat Autònoma de Barcelona
This study assessed the prevalence and patterns of drug use among people living with HIV (PLHIV) in Spain. We conducted an observational cross-sectional study including 1401 PLHIV. Data were collected through 33 sites across Spain using an online computer-assisted self-administered interview. [...]
2019 - 10.1371/journal.pone.0211252
PloS one, Vol. 14 Núm. 6 (june 2019) , p. e0211252
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14 p, 1.9 MB |
Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes
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Díaz de la Guardia, Rafael (Centro de Investigación Biomédica en Red de Cáncer) ;
Lopez-Millan, Belen (Centro de Investigación Biomédica en Red de Cáncer) ;
Lavoie, Jessie R. (Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate (Ottawa, Canadà)) ;
Bueno, Clara (Centro de Investigación Biomédica en Red de Cáncer) ;
Castaño Cardoso, Julio (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Casares, Maite (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Vives Polo, Susana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ;
Blanco, Maria L. (Institut d'Investigació Biomèdica Sant Pau) ;
Nomdedeu, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Chaparro, Alberto (Hospital Clínico San Carlos (Madrid)) ;
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Anguita, Eduardo (Hospital Clínico San Carlos (Madrid)) ;
Rosu-Myles, Michael (Regulatory Research Division, Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa,Canada) ;
Menéndez Bujan, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) are key components of the hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from patients with acute myeloid leukemia (AML) have been poorly characterized due to disease heterogeneity. [...]
2017 - 10.1016/j.stemcr.2017.04.019
Stem cell reports, Vol. 8 (may 2017) , p. 1573-1586
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17 p, 308.0 KB |
Staggered chromosomal hybrid zones in the house mouse : relevance to reticulate evolution and speciation
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Gündüz, İslam (University of York. Department of Biology) ;
Pollock, Christianne L. (University of York. Department of Biology) ;
Giménez, Mabel D. (University of York. Department of Biology) ;
Förster, Daniel W. (Durham University. School of Biological and Biomedical Sciences) ;
White, Thomas A. (Durham University. School of Biological and Biomedical Sciences) ;
Sans-Fuentes, Maria A. (Universitat de Barcelona. Departament de Biologia Animal) ;
Hauffe, Heidi C. (University of York. Department of Biology) ;
Ventura Queija, Jacinto (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
López-Fuster, María José (Universitat de Barcelona. Departament de Biologia Animal) ;
Searle, Jeremy B. (University of York. Department of Biology)
In the house mouse there are numerous chromosomal races distinguished by different combinations of metacentric chromosomes. These may come into contact with each other and with the ancestral all-acrocentric race, and form hybrid zones. [...]
2010 - 10.3390/genes1020193
Genes, Vol. 1, issue 2 (Sep. 2010) , p. 193-209
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17 p, 3.5 MB |
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency
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Muñoz López, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romero Moya, Damià (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Prieto, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramos Mejía, Verónica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palau de Miguel, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carvajal Vergara, Xonia (Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Giorgetti, Alessandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ford, Anthony (Institute of Cancer Research (London, Gran Bretanya)) ;
Lako, Majlinda (Newcastle University. Institute of Genetic Medicine) ;
Granada, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz Xivillé, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ;
Torres Ruíz, Raúl (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, Ronald W. (Erasmus University Medical Center (Rotterdam, Holanda)) ;
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Fraga, Mario F.. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Nakanishi, Mahito (National Institute of Advanced Industrial Science and Technology (Tsukuba, Japó)) ;
Cazzaniga, Giovanni (Università degli Studi di Milano-Bicocca) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Cobo, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Bayón, Gustavo (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. [...]
2016 - 10.1016/j.stemcr.2016.08.013
Stem cell reports, Vol. 7 Núm. 4 (October 2016)
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