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1.
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25 p, 2.4 MB |
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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Matuozzo, Daniela (University Paris Cité) ;
Talouarn, Estelle (University Paris Cité) ;
Marchal, Astrid (University Paris Cité) ;
Zhang, Peng (Rockefeller University) ;
Manry, Jeremy (University Paris Cité) ;
Seeleuthner, Yoann (University Paris Cité) ;
Zhang, Yu (Laboratory of Clinical Immunology and Microbiology) ;
Bolze, Alexandre (Helix) ;
Chaldebas, Matthieu (The Rockefeller University) ;
Milisavljevic, Baptiste (The Rockefeller University) ;
Gervais, Adrian (University Paris Cité) ;
Bastard, Paul (Necker Hospital for Sick Children) ;
Asano, Takaki (The Rockefeller University) ;
Bizien, Lucy (University Paris Cité) ;
Barzaghi, Federica (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Abolhassani, Hassan (Children's Medical Center) ;
Abou Tayoun, Ahmad (Mohammed Bin Rashid University of Medicine and Health Sciences) ;
Aiuti, Alessandro (Vita-Salute San Raffaele University) ;
Alavi Darazam, Ilad (Loghman Hakim Hospital) ;
Allende, Luis M. (Hospital 12 de Octubre (Madrid)) ;
Alonso-Arias, Rebeca (Hospital Universitario Central de Asturias) ;
Arias, Andrés Augusto (University of Antioquia UdeA) ;
Aytekin, Gokhan (Konya City Hospital) ;
Bergman, Peter (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Bondesan, Simone (IRCSS San Raffaele Scientific Institute) ;
Bryceson, Yenan (Karolinska Institutet (Estocolm, Suècia)) ;
Bustos, Ingrid G. (Universidad de La Sabana) ;
Cabrera-Marante, Oscar (Hospital Universitario La Paz (Madrid)) ;
Carcel, Sheila (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Carrera, Paola (IRCSS San Raffaele Scientific Institute) ;
Casari, Giorgio (Vita-Salute San Raffaele University) ;
Chaïbi, Khalil (Sorbonne University) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Condino-Neto, Antonio (University of São Paulo) ;
Covill, Laura E. (Karolinska Institutet (Estocolm, Suècia)) ;
Delmonte, Ottavia M. (Laboratory of Clinical Immunology and Microbiology) ;
El Zein, Loubna (Lebanese University) ;
Flores, Carlos (Universidad Fernando Pessoa Canarias) ;
Gregersen, Peter K. (Feinstein Institute for Medical Research) ;
Gut, Marta (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Haerynck, Filomeen (Jeffrey Modell Diagnosis and Research Centre) ;
Halwani, Rabih (University of Sharjah) ;
Hancerli, Selda (Istanbul University) ;
Hammarström, Lennart (Karolinska Institutet (Estocolm, Suècia)) ;
Hatipoğlu, Nevin (University of Health Sciences, Turkey) ;
Karbuz, Adem (Dr. Cemil Tascioglu City Hospital, Turkey) ;
Keles, Sevgi (Necmettin Erbakan University) ;
Kyheng, Christèle (Hôpital Bicêtre) ;
Leon-Lopez, Rafael (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Franco, Jose Luis (University of Antioquia UDEA) ;
Mansouri, Davood (Shahid Beheshti University of Medical Sciences) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Metin Akcan, Ozge (Necmettin Erbakan University) ;
Migeotte, Isabelle (Centre de Génétique Humaine de L'Université Libre de Bruxelles) ;
Morange, Pierre-Emmanuel (Aix-Marseille University) ;
Morelle, Guillaume (Hôpital Bicêtre) ;
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Novelli, Giuseppe (IRCCS Neuromed) ;
Novelli, Antonio (Bambino Gesù Children Hospital) ;
Ozcelik, Tayfun (Bilkent University) ;
Palabiyik, Figen (University of Health Sciences, Turkey) ;
Pan-Hammarström, Qiang (Karolinska Institutet (Estocolm, Suècia)) ;
de Diego, Rebeca Pérez (Hospital Universitario La Paz (Madrid)) ;
Planas-Serra, Laura (Institut d'Investigació Biomèdica de Bellvitge) ;
Pleguezuelo, Daniel E. (Hospital 12 de Octubre (Madrid)) ;
Prando, Carolina (Instituto de Pesquisa Pelé Pequeno Príncipe) ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Reyes, Luis Felipe (Universidad de La Sabana) ;
Rivière, Jacques G. (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Gallego, Carlos (Universidad Fernando Pessoa Canarias) ;
Rojas, Julian (University of Antioquia UDEA) ;
Rovere-Querini, Patrizia (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Schlüter, Agatha (Institut d'Investigació Biomèdica de Bellvitge) ;
Shahrooei, Mohammad (KU Leuven.) ;
Sobh, Ali (Mansoura University Children's Hospital) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ;
Tandjaoui-Lambiotte, Yacine (Avicenne Hospital) ;
Tipu, Imran (University of Management and Technology) ;
Tresoldi, Cristina (IRCCS Ospedale San Raffaele) ;
Troya, Jesus (Hospital Universitario Infanta Leonor) ;
van de Beek, Diederik (Amsterdam Neuroscience) ;
Zatz, Mayana (University of São Paulo) ;
Zawadzki, Pawel (Adam Mickiewicz University) ;
Al-Muhsen, Saleh Zaid (King Saud University) ;
Alosaimi, Mohammed Faraj (King Saud University) ;
Alsohime, Fahad M. (King Saud University) ;
Baris-Feldman, Hagit (Tel Aviv University) ;
Butte, Manish J. (University of California Los Angeles) ;
Constantinescu, Stefan N. (Oxford University) ;
Cooper, Megan A. (Washington University in St. Louis) ;
Dalgard, Clifton L. (Uniformed Services University of the Health Sciences) ;
Fellay, Jacques (Lausanne University Hospital) ;
Heath, James R. (Institute for Systems Biology) ;
Lau, Yu-Lung (Queen Mary Hospital) ;
Lifton, Richard P. (Yale School of Medicine) ;
Maniatis, Tom (New York Genome Center) ;
Mogensen, Trine H. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
von Bernuth, Horst (Charité - Universitätsmedizin Berlin) ;
Lermine, Alban (Laboratoire de Biologie Médicale Multisites Seqoia) ;
Vidaud, Michel (Laboratoire de Biologie Médicale Multisites Seqoia) ;
Boland, Anne (Université Paris-Saclay) ;
Deleuze, Jean-François (Université Paris-Saclay) ;
Nussbaum, Robert (Invitae) ;
Kahn-Kirby, Amanda (Invitae) ;
Mentre, France (Hôpital Bichat) ;
Tubiana, Sarah (Hôpital Bichat) ;
Gorochov, Guy (CIMI-Paris) ;
Tubach, Florence (Institut Pierre Louis d'Epidémiologie et de Santé Publique) ;
Hausfater, Pierre (Sorbonne Université) ;
Meyts, Isabelle (KU Leuven) ;
Zhang, Shen-Ying (The Rockefeller University) ;
Puel, Anne (The Rockefeller University) ;
Notarangelo, Luigi (Laboratory of Host Defenses) ;
Boisson-Dupuis, Stephanie (The Rockefeller University) ;
Su, Helen C. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ;
Boisson, Bertrand (The Rockefeller University) ;
Jouanguy, Emmanuelle (The Rockefeller University) ;
Casanova, Jean-Laurent (Howard Hughes Medical Institute) ;
Zhang, Qian (The Rockefeller University) ;
Abel, Laurent (The Rockefeller University) ;
Cobat, Aurélie (The Rockefeller University) ;
Universitat Autònoma de Barcelona
We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. [...]
2023 -  10.1186/s13073-023-01173-8
Genome Medicine, Vol. 15 (april 2023)
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2.
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22 p, 5.6 MB |
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
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Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Barmada, Anis (University of Cambridge. Department of Medical Genetics) ;
Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martins-Ferreira, Ricardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferreté-Bonastre, Anna G. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Sanmartín, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Rodriguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus, Hinxton, UK) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. [...]
2022 - 10.1186/s13073-022-01137-4
Genome Medicine, Vol. 14 (november 2022)
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3.
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16 p, 3.3 MB |
Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis
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Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ;
Rinas, Melanie (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Wirbel, Jakob (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Pertsovskaya, Inna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pliaka, Vicky (School of Mechanical Engineering, National Technical University of Athens) ;
Messinis, Dimitris E. (ProtATonce) ;
Vila, Gemma (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sakellaropoulos, Theodore (National Technical University of Athens) ;
Faigle, Wolfgang (University of Zurich) ;
Stridh, Pernilla (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Behrens, Janina R. (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Martin, Roland (University Hospital Zurich (Suïssa)) ;
Paul, Friedemann (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Alexopoulos, Leonidas G. (ProtATonce) ;
Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Saez-Rodriguez, Julio (Heidelberg University Hospital (Alemanya))
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects. [...]
2021 - 10.1186/s13073-021-00925-8
Genome Medicine, Vol. 13 (July 2021) , art. 117
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4.
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17 p, 3.1 MB |
Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci
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Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortiz-Fernández, Lourdes (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Javierre, B. M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Isac, E. (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Guillén-Del-Castillo, A. (Hospital Universitari Vall d'Hebron) ;
Simeón-Aznar, C. P. (Hospital Universitari Vall d'Hebron) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Universitat Autònoma de Barcelona
Background: Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. [...]
2020 - 10.1186/s13073-020-00779-6
Genome Medicine, Vol. 12 Núm. 1 (25 2020) , p. 81
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5.
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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6.
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23 p, 4.1 MB |
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
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Mateo, Lidia (Institute for Research in Biomedicine (IRB Barcelona)) ;
Duran-Frigola, Miquel (Institute for Research in Biomedicine (IRB Barcelona)) ;
Gris-Oliver, Albert (Vall d'Hebron Institut d'Oncologia) ;
Palafox, Marta (Vall d'Hebron Institut d'Oncologia) ;
Scaltriti, Maurizio (Memorial Sloan Kettering Cancer Center) ;
Razavi, Pedram (Memorial Sloan Kettering Cancer Center) ;
Chandarlapaty, Sarat (Memorial Sloan Kettering Cancer Center) ;
Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bellet Ezquerra, Meritxell (Vall d'Hebron Institut d'Oncologia) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats)
Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. [...]
2020 - 10.1186/s13073-020-00774-x
Genome Medicine, Vol. 12 (september 2020)
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7.
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18 p, 4.3 MB |
Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis
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Lorente-Sorolla, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Toledano, Víctor (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Avendaño-Ortiz, José (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Maroun-Eid, Charbel (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martín-Quirós, Alejandro (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Sanmartín, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Campo, Álvaro García (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut d'Investigació Biomèdica de Bellvitge) ;
Vall d'Hebron Institut de Recerca (VHIR)
Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation. [...]
2019 - 10.1186/s13073-019-0674-2
Genome Medicine, Vol. 11 (october 2019)
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8 p, 2.4 MB |
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
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Tamborero, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rubio-Perez, Carlota (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Deu-Pons, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Schroeder, Michael P. (Charité - Universitätsmedizin Berlin) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Rovira, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tusquets, Ignasi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Albanell Mestres, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodón Ahnert, Jordi (Vall d'Hebron Institut d'Oncologia) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
De Torres, Carmen (Institut de Recerca Sant Joan de Déu) ;
Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ;
Gonzalez-Perez, Abel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lopez-Bigas, Nuria (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. [...]
2018 - 10.1186/s13073-018-0531-8
Genome Medicine, Vol. 10 (March 2018) , art. 25
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12 p, 2.5 MB |
Cancer network activity associated with therapeutic response and synergism
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Serra-Musach, Jordi (Institut Català d'Oncologia) ;
Mateo, Francesca (Institut Català d'Oncologia) ;
Capdevila-Busquets, Eva (Institut de Recerca Biomèdica de Lleida) ;
de Garibay, Gorka Ruiz (Institut Català d'Oncologia) ;
Zhang, Xiaohu (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ;
Guha, Raj (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ;
Thomas, Craig J. (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ;
Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ;
Villanueva, Alberto (Institut Català d'Oncologia) ;
Jaeger, Samira (Institut de Recerca Biomèdica de Lleida) ;
Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ;
Vizoso, Miguel (Institut d'Investigació Biomèdica de Bellvitge) ;
Pérez Montero, Hector (Institut d'Investigació Biomèdica de Bellvitge) ;
Cordero, Alex (Institut d'Investigació Biomèdica de Bellvitge) ;
González Suarez, Eva (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ;
Moreno-Bueno, Gema (Universidad Autónoma de Madrid. Departamento de Bioquímica) ;
Tjärnberg, Andreas (Linköping University. Departament of Clinical and Experimental Medicine) ;
Lázaro, Conxi (Institut Català d'Oncologia) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Arribas, Joaquín V. (Vicente) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Benson, Mikael (Linköping University. Department of Clinical and Experimental Medicine) ;
Gustafsson, Mika (Linköping University. Department of Clinical and Experimental Medicine) ;
Ferrer, Marc (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ;
Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats) ;
Pujana, Miquel Àngel (Institut Català d'Oncologia)
Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. [...]
2016 - 10.1186/s13073-016-0340-x
Genome Medicine, Vol. 8 (August 2016) , ART. 88
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