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23.
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16 p, 2.9 MB |
Role of autophagy in von willebrand factor secretion by endothelial cells and in the in vivo thrombin-antithrombin complex formation promoted by the hiv-1 matrix protein p17
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Bugatti, A. (University of Brescia Medical School) ;
Marsico, S. (University of Calabria) ;
Mazzuca, P. (University of Brescia Medical School) ;
Schulze, K. (Helmholtz Center for Infection Research (HZI)) ;
Ebensen, T. (Helmholtz Center for Infection Research (HZI)) ;
Giagulli, C. (University of Brescia Medical School) ;
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Slevin, M. (Manchester Metropolitan University) ;
Caruso, A. (University of Brescia Medical School) ;
Guzman, C.A. (Helmholtz Center for Infection Research (HZI)) ;
Caccuri, F. (University of Brescia Medical School) ;
Universitat Autònoma de Barcelona
Although the advent of combined antiretroviral therapy has substantially improved the survival of HIV-1-infected individuals, non-AIDS-related diseases are becoming increasingly prevalent in HIV-1-infected patients. [...]
2020 -  10.3390/ijms21062022
International journal of molecular sciences, Vol. 21 Núm. 6 (february 2020) , p. 2022
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24.
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre de Regulació Genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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25.
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13 p, 1.5 MB |
Increase of Circulating Monocyte-Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage
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Mariscal, Anaís (Institut d'Investigació Biomèdica Sant Pau) ;
Zamora, Carles (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Díaz Torne, César (Institut d'Investigació Biomèdica Sant Pau) ;
Ortiz, M. Àngels (Institut d'Investigació Biomèdica Sant Pau) ;
de Agustín, Juan José (Hospital Universitari Vall d'Hebron) ;
Reina, Delia (Hospital de Sant Joan Despí Moisès Broggi) ;
Estrada, Paula (Hospital de Sant Joan Despí Moisès Broggi) ;
Moya, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Corominas, Hèctor (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Platelets (PLT) bind to a significant percentage of circulating monocytes and this im-munomodulatory interaction is increased in several inflammatory and autoimmune conditions. The therapeutic blockage of IL-6 with Tocilizumab (TCZ) alters PLT and the phenotype and function of monocytes in rheumatoid arthritis (RA). [...]
2022 - 10.3390/ijms23105748
International journal of molecular sciences, Vol. 23 Núm. 10 (May 2022) , p. 5748
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26.
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12 p, 3.0 MB |
Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation
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Masip, Jenifer (Hospital Universitari Joan XXIII de Tarragona) ;
Jorba, Rosa (Hospital Universitari Joan XXIII de Tarragona) ;
López Dupla, Jesús Miguel (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Yolanda María (Laboratorio de Inmunología. Instituto de Biomedicina de Sevilla. Hospital Universitario Virgen del Rocío. Consejo Superior de Investigaciones Científicas (Espanya). Universidad de Sevilla) ;
García-Pardo, Graciano (Hospital Universitari Joan XXIII de Tarragona) ;
Martínez, Esteban (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Viladés, Consuelo (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Veloso, Sergi (Hospital Universitari Joan XXIII de Tarragona) ;
Alba, Verónica (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Olona, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Vidal, Francesc (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Gómez-Bertomeu, Frederic (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Peraire, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Rull, Anna (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. [...]
2022 - 10.3390/ijms23158071
International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8071
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27.
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11 p, 4.4 MB |
Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells
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Marhuenda, Esther (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Villarino, Alvaro (Universitat de Barcelona) ;
Narciso, Maria Leonor (Universitat de Barcelona) ;
Camprubí-Rimblas, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gavara, Núria (Universitat de Barcelona) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Otero, Jorge (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in culture. This fact has previously been related to the translocation of the mechanosensing Yes-associated protein (YAP) to the nuclei and Rho signaling pathway. [...]
2022 - 10.3390/ijms23094888
International journal of molecular sciences, Vol. 23 (april 2022)
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28.
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12 p, 1.2 MB |
Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia
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Faura, Júlia (Hospital Universitari Vall d'Hebron) ;
Ramiro, Laura (Hospital Universitari Vall d'Hebron) ;
Simats Oriol, Alba (Hospital Universitari Vall d'Hebron) ;
Ma, Feifei (Hospital Universitari Vall d'Hebron) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron) ;
Bustamante, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. [...]
2022 - 10.3390/ijms23158093
International journal of molecular sciences, Vol. 23 (july 2022)
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29.
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10 p, 2.5 MB |
Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy (MNGIE) Patient Receiving Liver Transplant
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Boschetti, Elisa (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Caporali, Leonardo (IRCCS Istituto delle Scienze Neurologiche di Bologna) ;
D'Angelo, Roberto (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Malagelada Prats, Carolina (Hospital Universitari Vall d'Hebron) ;
Accarino, Ana María (Hospital Universitari Vall d'Hebron) ;
Dotti, Maria Teresa (University of Siena) ;
Costa, Roberta (University of Bologna) ;
Cenacchi, Giovanna (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Pironi, Loris (University of Bologna) ;
Rinaldi, Rita (IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
Stanghellini, Vincenzo (University of Bologna) ;
Ratti, Stefano (University of Bologna) ;
Manzoli, Lucia (University of Bologna) ;
Carelli, Valerio (IRCCS Istituto delle Scienze Neurologiche di Bologna) ;
De Giorgio, Roberto (University of Ferrara) ;
Universitat Autònoma de Barcelona
Mitochondrial neuro-gastrointestinal encephalomyopathy (MNGIE) is a rare genetic disorder characterized by thymidine phosphorylase (TP) enzyme defect. The absence of TP activity induces the imbalance of mitochondrial nucleotide pool, leading to impaired mitochondrial DNA (mtDNA) replication and depletion. [...]
2022 - 10.3390/ijms23158792
International journal of molecular sciences, Vol. 23 (august 2022)
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30.
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25 p, 5.2 MB |
Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy
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Arellano-Galindo, Lilia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Villar-Alvarez, Eva (Institut Català de Nanociència i Nanotecnologia) ;
Varela, Alejandro (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Figueroa, Valeria (Universidad de Guadalajara. Departamento de Ingeniería Química) ;
Fernandez-Vega, Javier (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Cambón, Adriana (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Prieto, Gerardo (Universidade de Santiago de Compostela. Departamento de Física Aplicada) ;
Barbosa, Silvia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Taboada, Pablo (Universidade de Santiago de Compostela. Departamento de Física de Partículas)
Metal nanoparticles (NPs), particularly gold nanorods (AuNRs), appear as excellent platforms not only to transport and deliver bioactive cargoes but also to provide additional therapeutic responses for diseased cells and tissues and/or to complement the action of the carried molecules. [...]
2022 - 10.3390/ijms232113109
International journal of molecular sciences, Vol. 23, Issue 21 (October 2022) , art. 13109
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31.
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15 p, 1.9 MB |
GC-MS/MS Determination of Synthetic Cathinones : 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study
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Nuñez-Montero, Melani (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lombroni, Claudia (Univesità degli Studi di Torino) ;
Maida, Nunzia La (Istituto Superiore di Sanità) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marchei, Emilia (Istituto Superiore di Sanità) ;
Universitat Autònoma de Barcelona
This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. [...]
2023 - 10.3390/ijms24119387
International journal of molecular sciences, Vol. 24 (may 2023)
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32.
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15 p, 2.4 MB |
IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells
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Riquelme-Neira, Roberto (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Walker-Vergara, Romina (Universidad de Las Américas) ;
Fernández-Blanco, Joan Antoni (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vergara, Patri (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Mast cells (MCs) are involved in several immune-related responses, including those in bacterial infections, autoimmune diseases, inflammatory bowel diseases, and cancer, among others. MCs identify microorganisms by pattern recognition receptors (PRRs), activating a secretory response. [...]
2023 - 10.3390/ijms24129875
International journal of molecular sciences, Vol. 24 (june 2023)
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