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6 p, 820.8 KB Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease / Dalmasso, M.C. (Laboratory of Amyloidosis and Neurodegeneration. Fundación Instituto Leloir-IIBBA-CONICET. Ciudad Autónoma de Buenos Aires (C.A.B.A.)) ; Brusco, L.I. (Hospital Interzonal General de Agudos Eva Perón) ; Olivar, N. (Departamento Ciencias Fisiológicas UAII. Facultad de Medicina. UBA. C.A.B.A) ; Muchnik, C. (Laboratorio de Bioquímica Molecular. Facultad de Medicina. Instituto de Investigaciones Médicas A. Lanari. UBA. C.A.B.A) ; Hanses, C. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Milz, E. (Division of Neurogenetics and Molecular Psychiatry. Department of Psychiatry and Psychotherapy. University of Cologne) ; Becker, J. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Heilmann-Heimbach, S. (Department of Genomics. Life & Brain Center. University of Bonn) ; Hoffmann, P. (Division of Medical Genetics. University Hospital and Department of Biomedicine. University of Basel) ; Prestia, F.A. (Laboratory of Amyloidosis and Neurodegeneration. Fundación Instituto Leloir-IIBBA-CONICET. Ciudad Autónoma de Buenos Aires (C.A.B.A.)) ; Galeano, P. (Laboratory of Amyloidosis and Neurodegeneration. Fundación Instituto Leloir-IIBBA-CONICET. Ciudad Autónoma de Buenos Aires (C.A.B.A.)) ; Avalos, M.S.S. (Ministerio de Salud de la Provincia de Jujuy. Programa del Adulto Mayor. San Salvador de Jujuy) ; Martinez, L.E. (Hospital Interzonal General de Agudos Eva Perón) ; Carulla, M.E. (Hospital Interzonal General de Agudos Eva Perón) ; Azurmendi, P.J. (Laboratorio de Bioquímica Molecular. Facultad de Medicina. Instituto de Investigaciones Médicas A. Lanari. UBA. C.A.B.A) ; Liberczuk, C. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A) ; Fezza, C. (Laboratorio de Bioquímica Molecular. Facultad de Medicina. Instituto de Investigaciones Médicas A. Lanari. UBA. C.A.B.A) ; Sampaño, M. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A) ; Fierens, M. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A) ; Jemar, G. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A) ; Solis, P. (Neurosciences and Complex Systems Unit (EnyS). CONICET. Hospital El Cruce "Dr. Néstor Kirchner". Univ Arturo Jauretche) ; Medel, N. (Neurosciences and Complex Systems Unit (EnyS). CONICET. Hospital El Cruce "Dr. Néstor Kirchner". Univ Arturo Jauretche) ; Lisso, J. (Neurosciences and Complex Systems Unit (EnyS). CONICET. Hospital El Cruce "Dr. Néstor Kirchner". Univ Arturo Jauretche) ; Sevillano, Z. (Neurosciences and Complex Systems Unit (EnyS). CONICET. Hospital El Cruce "Dr. Néstor Kirchner". Univ Arturo Jauretche) ; Bosco, P. (Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl) ; Bossù, P. (Department of Clinical and Behavioural Neurology. Experimental Neuropsychobiology Laboratory) ; Spalletta, G. (Department of Clinical and Behavioural Neurology. Neuropsychiatry Laboratory. IRCCS Santa Lucia Foundation) ; Galimberti, D. (Neurodegenerative Diseases Center. University of Milan. Centro Dino Ferrari. Fondazione Ca' Granda. IRCCS Ospedale Maggiore Policlinico) ; Mancuso, M. (Department of Experimental and Clinical Medicine. Neurological Institute. University of Pisa) ; Nacmias, B. (NEUROFARBA (Department of Neuroscience. Psychology. Drug Research and Child Health). University of Florence) ; Sorbi, S. (IRCCS 'Don Carlo Gnocchi') ; Mecocci, P. (Section of Gerontology and Geriatrics. Department of Medicine. University of Perugia) ; Pilotto, A. (Geriatric Unit and Gerontology-Geriatrics Research Laboratory. Department of Medical Sciences. IRCCS Casa Sollievo della Sofferenza) ; Caffarra, P. (Alzheimer Center. FERB) ; Panza, F. (Neurodegenerative Disease Unit. Department of Basic Medicine. Neuroscience. and Sense Organs. University of Bari Aldo Moro) ; Bullido, M. (Centro de Biología Molecular Severo Ochoa (CSIC-UAM)) ; Clarimon, J. (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez-Juan, P. (Neurology Service and CIBERNED. 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL)) ; Coto, E. (Molecular Genetics Laboratory-Hospital. University of Central Asturias) ; Sanchez-Garcia, F. (Immunology Service. Hospital Universitario de Gran Canaria Doctor Negrín) ; Graff, C. (Division of Neurogeriatrics. Department NVS. Karolinska Institutet) ; Ingelsson, M. (Department of Public Health/Geriatrics. Uppsala University) ; Bellenguez, C. (University Lille. U1167-Excellence Laboratory LabEx DISTALZ) ; Castaño, E.M. (Laboratory of Amyloidosis and Neurodegeneration. Fundación Instituto Leloir-IIBBA-CONICET. Ciudad Autónoma de Buenos Aires (C.A.B.A.)) ; Kairiyama, C. (Hospital Interzonal General de Agudos Eva Perón) ; Politis, D.G. (Hospital Interzonal General de Agudos Eva Perón) ; Kochen, S. (Neurosciences and Complex Systems Unit (EnyS). CONICET. Hospital El Cruce "Dr. Néstor Kirchner". Univ Arturo Jauretche) ; Scaro, H. (Ministerio de Salud de la Provincia de Jujuy. Programa del Adulto Mayor. San Salvador de Jujuy) ; Maier, W. (Department of Neurodegenerative Diseases and Geriatric Psychiatry. University of Bonn) ; Jessen, F. (Department of Psychiatry and Psychotherapy. University of Cologne) ; Mangone, C.A. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A) ; Lambert, J.C. (University Lille. U1167-Excellence Laboratory LabEx DISTALZ) ; Morelli, Laura (Laboratory of Amyloidosis and Neurodegeneration. Fundación Instituto Leloir-IIBBA-CONICET. Ciudad Autónoma de Buenos Aires (C.A.B.A.)) ; Ramirez, A. (Department of Neurodegenerative Diseases and Geriatric Psychiatry. University of Bonn) ; Universitat Autònoma de Barcelona
Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. [...]
2019 - 10.1038/s41398-019-0394-9
Translational psychiatry, Vol. 9 Núm. 1 (january 2019) , p. 55  

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