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15 p, 739.8 KB |
Advances in diagnostic tools for respiratory tract infections : from tuberculosis to COVID-19 - changing paradigms?
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Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonçalves-Carvalho, Filipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Respiratory tract infections (RTIs) are one of the most common reasons for seeking healthcare, but are amongst the most challenging diseases in terms of clinical decision-making. Proper and timely diagnosis is critical in order to optimise management and prevent further emergence of antimicrobial resistance by misuse or overuse of antibiotics. [...]
2022 -  10.1183/23120541.00113-2022
ERJ Open Research, Vol. 8 (september 2022)
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2.
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12 p, 1.4 MB |
Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment
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Díaz-Fernández, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Tolosa, Guillermo (Universidad de la Frontera) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Safont Gonzalez, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero i Andrada, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sabrià, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Current blood-based diagnostic tools for TB are insufficient to properly characterize the distinct stages of TB, from the latent infection (LTBI) to its active form (aTB); nor can they assess treatment efficacy. [...]
2022 - 10.3389/fmicb.2022.885312
Frontiers in microbiology, Vol. 13 (july 2022)
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6 p, 109.5 KB |
Microbiologia clínica [101006]
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Julián Gómez, Esther ;
Latorre, Irene ;
Universitat Autònoma de Barcelona.
Facultat de Biociències
En aquesta assignatura es pretén que l'alumnat: - Conegui els grups més importants de microorganismes patògens per l'home. - Conegui les bases del diagnòstic microbiològic d'una malaltia infecciosa humana. [...]
In this subject it is intended that the student: - Know the most important groups of pathogenic microorganisms for humans. - Know the basics of the microbiological diagnosis of a human infectious disease. [...]
En esta asignatura se pretende que el alumnado: - Conozca los grupos más importantes de microorganismos patógenos para el hombre. - Conozca las bases del diagnóstico microbiológico de una enfermedad infecciosa humana. [...]
2023-24
Grau en Microbiologia [816]
3 documents
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4.
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14 p, 899.9 KB |
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
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Safont, G. (Universitat Autònoma de Barcelona) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Stojanovic, Zorac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Cano, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona) ;
Molina-Moya, Bárbara (Universitat Autònoma de Barcelona) ;
Solis, Alan Jhurior (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arméstar, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz-Fernández, Sergio (Universitat Autònoma de Barcelona) ;
Cendón Esteve, Arnau (Universitat Autònoma de Barcelona) ;
Sokalchuk, Liliya (Universitat Autònoma de Barcelona) ;
Tolosa, Guillermo (Diagnostic and Research in Immunodeficiencies Jeffrey Modell Center. Cytometry and Cellular Culture Area. La Frontera University) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Universitat Autònoma de Barcelona)
The measurement of specific T-cell responses can be a useful tool for COVID-19 diagnostics and clinical management. In this study, we evaluated the IFN-γ T-cell response against the main SARS-CoV-2 antigens (spike, nucleocapsid and membrane) in acute and convalescent individuals classified according to severity, and in vaccinated and unvaccinated controls. [...]
2022 - 10.3390/jcm11175103
Journal of clinical medicine, Vol. 11 Núm. 17 (september 2022) , p. 5103
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12 p, 995.8 KB |
Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
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Altet, Neus (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Godoy, Pere (Institut de Recerca Biomèdica de Lleida) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. [...]
2022 - 10.3390/jcm11072000
Journal of clinical medicine, Vol. 11 (april 2022)
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6.
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13 p, 1.6 MB |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
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Serra-Vidal, Mᵃdel Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. C. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Díaz, Jéssica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maldonado, José (Serveis Clínics (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Solsona, Jordi (Hospital Universitari Vall d'Hebron) ;
Jimenez-Fuentes, M. Ángeles (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Department of Immunohematology and Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo -expressed Mycobacterium tuberculosis (IVE-TB) antigens. [...]
2014 - 10.3389/fmicb.2014.00517
Frontiers in microbiology, Vol. 5 (october 2014)
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1.2 MB |
Impact of Host Genetics and Biological Response Modifiers on Respiratory Tract Infections
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Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mateo, Lourdes (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Méndez, María Jesús (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Rodrigo Gonzalo de Líria, Carlos (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villar-Hernandez, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Host susceptibility to respiratory tract infections (RTI) is dependent on both genetic and acquired risk factors. Repeated bacterial and viral RTI, such as pneumonia from encapsulated microorganisms, respiratory tract infections related to respiratory syncytial virus or influenza, and even the development of bronchiectasis and asthma, are often reported as the first symptom of primary immunodeficiencies. [...]
2019 - 10.3389/fimmu.2019.01013
Frontiers in immunology, Vol. 10 (may 2019)
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11 p, 1.8 MB |
Diagnostic benefits of adding EspC, EspF and Rv2348-B to the QuantiFERON Gold In-tube antigen combination
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Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Blauenfeldt, Thomas (Statens Serum Institut) ;
García-García, Esther (Universitat Autònoma de Barcelona) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalvá, Adrian (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, J. (Hospital Universitari Vall d'Hebron) ;
Jiménez, M. A. (Hospital Universitari Vall d'Hebron) ;
Centeno Clemente, Carmen Angela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel D. (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat Aymerich, Cristina (Utrecht University) ;
Andersen, Peter Lawætz (Statens Serum Institut) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Ruhwald, Morten (Statens Serum Institut) ;
Domínguez, Jose (Universitat Autònoma de Barcelona)
Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. [...]
2020 - 10.1038/s41598-020-70204-w
Scientific reports, Vol. 10 (august 2020)
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12 p, 768.3 KB |
Serial testing of health care workers for tuberculosis infection : A prospective cohort study
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Casas, Irma (Universitat Autònoma de Barcelona) ;
Esteve, Maria (Universitat Autònoma de Barcelona) ;
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mena, Guillermo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Health Care Workers (HCW) may have an occupational risk of latent tuberculosis infection (LTBI) and TB disease. The objective of this study was to evaluate the performance of the 2-step strategy: tuberculin skin test (TST) followed by confirmation with Interferon (IFN)-γ- release assays (IGRAs) in HCW. [...]
2020 - 10.1371/journal.pone.0235986
PloS one, Vol. 15 (july 2020)
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10.
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1.5 MB |
Cell-Mediated Immune Responses to in vivo -Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups
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Coppola, Mariateresa (Leiden University Medical Center) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
van Meijgaarden, Krista E. (Leiden University Medical Center) ;
Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. M. C. (Leiden University Medical Center) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Universitat Autònoma de Barcelona. Departament de Medicina) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (CIBER de Epidemiología y Salud Pública (CIBEREESP)) ;
Sabriá, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Noguera-Julian, Antoni (Institut de Recerca Sant Joan de Déu) ;
Geluk, Annemieke (Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Leiden University Medical Center)
A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. [...]
2020 - 10.3389/fimmu.2020.00103
Frontiers in immunology, Vol. 11 (february 2020)
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