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15 p, 1.8 MB Deoxygedunin, a natural product with potent neurotrophic activity in mice / Jang, Sung-Wuk (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ; Liu, Xia (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ; Chan, Chi Bun (Emory University. School of Medicine. Department of Pathology and Laboratory Medicine) ; France, Stefan A. (Georgia Institute of Technology. School of Chemistry and Biochemistry) ; Sayeed, Iqbal (Emory University. School of Medicine. Department of Emergency Medicine) ; Tang, Wenxue (Emory University. School of Medicine. Department of Otolaryngology and Cell Biology) ; Lin, Xi (Emory University. School of Medicine. Department of Otolaryngology and Cell Biology) ; Xiao, Ge (Centers for Disease Control and Prevention (U.S.)) ; Andero Galí, Raul (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chang, Qiang (University of Wisconsin-Madison. Department of Genetics and Neurology) ; Ressler, Kerry J. (Emory University. School of Medicine. Department of Psychiatry and Behavioral Science) ; Ye, Keqiang (Emory University. Department of Pathology and Laboratory Medicine)
Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. [...]
2010 - 10.1371/journal.pone.0011528.g001
PloS one, Vol. 5 Issue 7 (July 2010) , p. e11528  

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