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40.
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41.
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42.
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43.
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15 p, 2.1 MB |
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
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Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bilbao, Eneritz (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Agulló, Luis (Universitat de Vic. Departament de Biociències) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieto-Garai, Jon A. (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Contreras, F. Xabier (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Floor, Martin (Universitat de Vic. Departament de Biociències) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Villà-Freixa, Jordi (Universitat de Vic. Departament de Biociències) ;
Lorizate, Maier (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. [...]
2017 -  10.1038/srep40800
Scientific reports, gener 2017, p. 1-15
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44.
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15 p, 4.1 MB |
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART
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Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ;
Pou, Christian (Karolinska Institutet (Estocolm, Suècia). Department of Cell and Molecular Biology) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ;
Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ;
Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)
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45.
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11 p, 635.6 KB |
P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load
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Minuesa, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arimany-Nardi, Cristina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Clotet Sala, Bonaventura (Institució Catalana de Recerca i Estudis Avançats) ;
Pastor-Anglada, Marçal (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Martínez Picado, Francisco Javier (Universitat de Vic - Universitat Central de Catalunya)
To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. [...]
2016 - 10.1093/jac/dkw215
Journal of antimicrobial chemotherapy, Vol. 71 (june 2016) , p. 2782-2792
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46.
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11 p, 679.0 KB |
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4 + T-cell recovery once HIV-1 suppression is achieved?
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Jarrin, Inma (Instituto de Salud Carlos III) ;
Pantazis, Nikos (Athens University Medical School, Athens, Greece) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Phillips, Andrew N. (Research Department of Infection and Population Health) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Mussini, Cristina (Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy) ;
Boufassa, Faroudy (Univ Paris-Sud, Le Kremlim Bicetre) ;
Costagliola, Dominique (INSERM, Paris, France) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Del Amo, Julia (Instituto de Salud Carlos III) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
This article compares trends in CD4 + T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. [...]
2015 - 10.1097/QAD.0000000000000805
AIDS, Vol. 29 (october 2015) , p. 2323-2333
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47.
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10 p, 372.9 KB |
(2-{[2-(diphenyl-phosphino)phen-yl]thio}-phen-yl)diphenyl-phosphine sulfide
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Alvarez-Larena, Angel (Universitat Autònoma de Barcelona. Servei de Difracció de Raigs X) ;
Martinez-Cuevas, Francisco J. (Universitat Autònoma de Barcelona. Departament de Química) ;
Flor Pujadas, Teresa (Universitat Autònoma de Barcelona. Departament de Química) ;
Real i Obradors, Juli (Universitat Autònoma de Barcelona. Departament de Química)
In the title compound, CHPS, the dihedral angle between the central benzene rings is 66. 95 (13)°. In the crystal, molecules are linked via C-H⋯π and π-π interactions [shortest centroid-centroid distance between benzene rings = 3. [...]
2012 - 10.1107/S1600536812041347
Acta crystallographica. Section E : Structure reports online, Vol. 68 (Nov. 2012) , art. o3094
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48.
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15 p, 1.4 MB |
Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ;
Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casas, Josefina (Institut de Química Avançada de Catalunya) ;
Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ;
Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)
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49.
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11 p, 727.0 KB |
Equilibrios minerales y zonación de granates en el nucleo del domo del Tormes (provincias de Salamanca y Zamora)
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Sebastián Castellanos, Alfredo (Universitat Autònoma de Barcelona. Departament de Geologia) ;
Martínez Fernández, Francisco J. (Universitat Autònoma de Barcelona. Departament de Geologia)
El estudio de la zonación en 1os granates de gneises pelíticos pertenecientes al núcleo del domo del Tormes indica el carácter retrógrado de estos y confirma la existencia de las siguientes reacciones observadas petrográficamente en anteriores trabajos: Gt+Als+Qz+H,O -> Cd ; Bi+Als+Qz -> Cd+Fk+H,O ; Bi+Als+Qz->Gt+Cd+Fk+H20; CaGt+Als+Qz ->Capl. [...]
Garnets in the Tormes dome core area show a conspicuous retrograde diffusion zoning. The Fe, Mg, Ca, and Mn distribution in this mineral is consistent whith the reactions Gt+Als+Qz+H,O > Cd; Bi+Als+Qz -> Cd+Fk+H,O;Bi+Als+Qz -> Gt+Cd+Fk+H,O CaGt+Als+Qz-> CaPl petrographicaly predicted in previous papers. [...]
1989
Acta geologica hispanica, Vol. 24 Núm. 2 (1989) , p. 103-113
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