Dipòsit Digital de Documents de la UAB 46 registres trobats  anterior11 - 20següentfinal  anar al registre: La cerca s'ha fet en 0.01 segons. 
11.
5 p, 243.9 KB Biological activities of histidine-rich peptides; merging biotechnology and nanomedicine / Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Kumar, Pradeep (CSIR-Institute of Genomics and Integrative Biology) ; Cedano Rodríguez, Juan Antonio (Universidad de la República (Uruguay).) ; Gupta, Kailash C (CSIR-Indian Institute of Toxicology Research) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Histidine-rich peptides are commonly used in recombinant protein production as purification tags, allowing the one-step affinity separation of the His-tagged proteins from the extracellular media or cell extracts. [...]
2011 - 10.1186/1475-2859-10-101
Microbial cell factories, Vol. 10 (2011) , art. 101  
12.
7 p, 370.3 KB Co-production of GroELS discriminates between intrinsic and thermally-induced recombinant protein aggregation during substrate quality control / Platas, Gemma (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rodríguez-Carmona, Escarlata (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; García Fruitós, Elena (CIBER de Bioingeniería, Biomateriales y Nanomedicina) ; Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia
The effects and effectiveness of the chaperone pair GroELS on the yield and quality of recombinant polypeptides produced in Escherichia coli are matter of controversy, as the reported activities of this complex are not always consistent and eventually indicate undesired side effects. [...]
2011 - 10.1186/1475-2859-10-79
Microbial cell factories, Vol. 10 (October 2011) , art. 79  
13.
6 p, 314.6 KB Post-production protein stability : trouble beyond the cell factory / Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Being protein function a conformation-dependent issue, avoiding aggregation during production is a major challenge in biotechnological processes, what is often successfully addressed by convenient upstream, midstream or downstream approaches. [...]
2011 - 10.1186/1475-2859-10-60
Microbial cell factories, Vol. 10 (2011) , art. 60  
14.
4 p, 264.4 KB Engineering building blocks for self-assembling protein nanoparticles / Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Like natural viruses, manmade protein cages for drug delivery are to be ideally formed by repetitive subunits with self-assembling properties, mimicking viral functions and molecular organization. Naturally formed nanostructures (such as viruses, flagella or simpler protein oligomers) can be engineered to acquire specific traits of interest in biomedicine, for instance through the addition of cell targeting agents for desired biodistribution and specific delivery of associated drugs. [...]
2010 - 10.1186/1475-2859-9-101
Microbial Cell Factories, Vol. 9, Issue 101 (Dec. 2010)  
15.
6 p, 410.5 KB Side effects of chaperone gene co-expression in recombinant protein production / Martínez Alonso, Mónica (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; García Fruitós, Elena (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Rinas, Ursula (Leibniz Universität Hannover) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Insufficient availability of molecular chaperones is observed as a major bottleneck for proper protein folding in recombinant protein production. Therefore, co-production of selected sets of cell chaperones along with foreign polypeptides is a common approach to increase the yield of properly folded, recombinant proteins in bacterial cell factories. [...]
2010 - 10.1186/1475-2859-9-64
Microbial Cell Factories, Vol. 9, Issue 64 (September 2010)  
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5 p, 230.8 KB Learning about protein solubility from bacterial inclusion bodies / Martínez Alonso, Mónica (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González Montalbán, Nuria (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; García Fruitós, Elena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
The progressive solving of the conformation of aggregated proteins and the conceptual understanding of the biology of inclusion bodies in recombinant bacteria is providing exciting insights on protein folding and quality. [...]
2009 - 10.1186/1475-2859-8-4
Microbial Cell Factories, Vol. 8, Issue 4 (January 2009)  
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6 p, 267.7 KB The scientific impact of microbial cell factories / De Felice, Maurilio (Università degli Studi di Napoli Federico II. Department of Structural and Functional Biology) ; Mattanovich, Diethard (Universität für Bodenkultur Wien. Department of Biotechnology) ; Papagianni, Maria (Aristotle University of Thessaloniki. School of Veterinary Medicine) ; Wegrzyn, Grzegorz (Uniwersytet Gdański. Department of Molecular Biology) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Institut de Biotecnologia i Biomedicina "Vicent Villar Palasí"
2008 - 10.1186/1475-2859-7-33
Microbial Cell Factories, Vol. 7, Issue 33 (Desember 2008)  
18.
15 p, 3.4 MB Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins / Mamat, Uwe (Forschungszentrum Borstel) ; Wilke, Kathleen (Forschungszentrum Borstel) ; Bramhill, David (Research Corporation Technologies (Tucson)) ; Schromm, Andra Beate (Forschungszentrum Borstel) ; Lindner, Buko (Forschungszentrum Borstel) ; Kohl, Thomas Andreas (Forschungszentrum Borstel) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Schaffer, Lana (Scripps Research Institute) ; Head, Steven Robert (Scripps Research Institute) ; Souvignier, Chad (Research Corporation Technologies (Tucson)) ; Meredith, Timothy Charles (Pennsylvania State University. Department of Biochemistry and Molecular Biology) ; Woodard, Ronald Wesley (Bramhill Biological Consulting)
Background: lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a potent agonist for Toll-like receptor 4/myeloid differentiation factor 2-mediated pro-inflammatory activity in mammals and, thus, represents the endotoxic principle of LPS. [...]
2015 - 10.1186/s12934-015-0241-5
Microbial cell factories, Vol. 14, Issue 57 (2015)  
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7 p, 774.5 KB Expanding the recombinant protein quality in Lactococcus lactis / Cano Garrido, Olivia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Rueda, Fabián L. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Sànchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ruiz-Ávila, Luis (Spherium Biomed S.L.) ; Bosser, Ramon (Spherium Biomed S.L.) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Background: Escherichia coli has been a main host for the production of recombinant proteins of biomedical interest, but conformational stress responses impose severe bottlenecks that impair the production of soluble, proteolytically stable versions of many protein species. [...]
2014 - 10.1186/s12934-014-0167-3
Microbial cell factories, Vol. 13 (2014) , p. 167  
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16 p, 1.0 MB Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system : application on Pichia pastoris producing Rhizopus oryzae lipase / Hemmerich, Johannes (m2p-labs GmbH) ; Adelantado Vallvé, Núria (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química) ; Barrigón de San Marcos, José (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química) ; Ponte, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química) ; Hörmann, Astrid (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Kensy, Frank (m2p-labs GmbH) ; Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
Background: In Pichia pastoris bioprocess engineering, classic approaches for clone selection and bioprocess optimization at small/micro scale using the promoter of the alcohol oxidase 1 gene (PAOX1), induced by methanol, present low reproducibility leading to high time and resource consumption. [...]
2014 - 10.1186/1475-2859-13-36
Microbial cell factories, Vol. 13, No. 36 (March 2014) , p. 1-16  

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