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1.
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13 p, 7.4 MB |
Zn(II) and Cd(II) complexes with 3-furoic acid. Exploring the role of C-H···O interactions
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Sanchez Ferez, Francisco (Universitat Autònoma de Barcelona. Departament de Química) ;
Ejarque, Daniel (Universitat Autònoma de Barcelona. Departament de Química) ;
Calvet, Teresa (Universitat de Barcelona. Departament de Mineralogia, Petrologia i Geologia Aplicada) ;
Font-Bardia, Mercè (Universitat de Barcelona. Unitat de Difracció de Raig-X) ;
Pons Picart, Josefina (Universitat Autònoma de Barcelona. Departament de Química)
Hydrogen bond interactions implying Csingle bondH groups and O atoms either from carboxylate, carbonyl, or ether functionalities have been demonstrated to play a pivotal role in the packing of crystal structures. [...]
2024 -  10.1016/j.molstruc.2024.138206
Journal of molecular structure, Vol. 1309 (August 2024) , art. 138206
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2.
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16 p, 5.9 MB |
Adipokines as New Biomarkers of Immune Recovery : Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy
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Yeregui, Elena (Instituto de Salud Carlos III) ;
Masip, J. (Instituto de Salud Carlos III) ;
Viladés, C. (Instituto de Salud Carlos III) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Y.M. (Universidad de Sevilla) ;
Blanco, J. (Universitat de Vic - Universitat Central de Catalunya) ;
Mallolas Masferrer, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alba, Verónica (Instituto de Salud Carlos III) ;
Vargas, M. (Instituto de Salud Carlos III) ;
García-Pardo, G. (Instituto de Salud Carlos III) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Olona, M. (Instituto de Salud Carlos III) ;
Vidal-González, J. (Universitat de Barcelona) ;
Peraire, M. (Universitat Rovira i Virgili) ;
Martí, A. (Instituto de Salud Carlos III) ;
Reverté, L. (Instituto de Salud Carlos III) ;
Gómez-Bertomeu, F. (Instituto de Salud Carlos III) ;
Leal, M. (Hospital Viamed Santa Ángela de la Cruz) ;
Vidal, F. (Instituto de Salud Carlos III) ;
Peraire, J. (Instituto de Salud Carlos III) ;
Rull, A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. [...]
2022 - 10.3390/ijms23042202
International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202
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3.
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17 p, 3.9 MB |
Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed : The Impact of Diet and Statin Treatment in a Preclinical Animal Model
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Schoch, Leonie (Institut d'Investigació Biomèdica Sant Pau) ;
Sutelman, P. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Suades, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Casani, L. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
High-density lipoproteins (HDL) undergo adverse remodeling and loss of function in the presence of comorbidities. We assessed the potential of lipid-lowering approaches (diet and rosuvastatin) to rescue hypercholesterolemia-induced HDL dysfunction. [...]
2022 - 10.3390/ijms23158596
International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8596
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4.
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5.
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18 p, 1.8 MB |
Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection
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Gallardo-Gómez, María (Universidade de Vigo) ;
Costas-Ríos, Lara (Universidade de Vigo) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Rodríguez, Lara (Universidade de Vigo) ;
Bujanda, Luis (Universidad del País Vasco (UPV/EHU)) ;
Barrero, Maialen (Hospital Universitario Donostia) ;
Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ;
González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ;
Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ;
De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 - 10.1002/1878-0261.13573
Molecular Oncology, 2023
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6.
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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - 10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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7.
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14 p, 7.4 MB |
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
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Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ;
Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ;
Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ;
Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ;
Matsuba, Chikako (University of Southern California, Los Angeles, USA) ;
Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ;
Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ;
Unzueta, Fernando (Universitat de Barcelona) ;
Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ;
Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ;
Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ;
Cortés, Javier (Universidad Europea de Madrid) ;
DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lupien, Mathieu (University of Toronto) ;
Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - 10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)
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8.
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16 p, 3.5 MB |
Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas
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Matas-Nadal, Clara (Hospital de Santa Caterina (Salt, Girona)) ;
Bech-Serra, Joan-Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gatius, Sònia (Hospital Universitari Arnau de Vilanova) ;
Gomez, Xavier (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Ribes-Santolaria, Marina (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Guasch-Vallés, Marta (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Pedraza, Neus (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Casanova, Josep M. (Hospital Universitari Arnau de Vilanova) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gari, Eloi (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Aguayo-Ortiz, Rafael S. (Hospital Universitari Arnau de Vilanova)
Basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (SCCs) are the most frequent types of cancer, and both originate from the keratinocyte transformation, giving rise to the group of tumors called keratinocyte carcinomas (KCs). [...]
2023 - 10.1016/j.mcpro.2023.100547
Molecular and Cellular Proteomics, Vol. 22 Núm. 6 (june 2023) , p. 100547
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9.
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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 - 10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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10.
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12 p, 1.7 MB |
Roles of lncRNAs in brain development and pathogenesis : Emerging therapeutic opportunities
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Srinivas, Tara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mathias, Carolina (Federal University of Parana, Curitiba, Brazil) ;
Oliveira-Mateos, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The human genome is pervasively transcribed, producing a majority of short and long noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of transcriptional and post-transcriptional regulatory mechanisms. [...]
2023 - 10.1016/j.ymthe.2023.02.008
Molecular Therapy, Vol. 31 Núm. 6 (july 2023) , p. 1550-1561
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