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1.
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10 p, 2.3 MB |
Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquin (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona) ;
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona) ;
Tur, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: The combination of anatomical MRI and deep learning-based methods such as convolutional neural networks (CNNs) is a promising strategy to build predictive models of multiple sclerosis (MS) prognosis. [...]
2023 -  10.1002/jmri.29046
Journal of Magnetic Resonance Imaging
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2.
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231 p, 7.7 MB |
Clinical monitoring of multiple sclerosis patients using digital technology
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Midaglia Fernández, Luciana ;
Montalbán Gairín, Xavier, dir. ;
Sastre Garriga, Jaume, dir. ;
Fonollosa Pla, Vicent, dir.
La tesi es basa en lús de la tecnologia digital, en aquest cas una aplicació, per al seguiment clínic de pacients amb esclerosi múltiple. La intenció final d'aquesta aplicació és alertar el clínic sobre l'aparició de símptomes subclínics i, per tant, la progressió de la malaltia.
La tesis se basa en el uso de la tecnología digital, en este caso una aplicación, para el seguimiento clínico de pacientes con esclerosis múltiple. La intención final de esta aplicación es alertar al clínico sobre la aparición de síntomas subclínicos y, por tanto, sobre la progresión de la enfermedad.
The thesis is based on the use of digital technology, in this case an application, for the clinical monitoring of patients with multiple sclerosis. The final intention of this application is to alert the clinician about the appearance of subclinical symptoms and, therefore, about the progression of the disease.
2023
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3.
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7 p, 817.8 KB |
Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis : results from the HEBEM study
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Marzo Escartin, Blanca (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Robles-Sanchez, Miguel-Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina)
INTRODUCTION: Prospective data on the risk of hepatitis B reactivation (HBVr) among patients with resolved HBV infection undergoing anti-CD20 antibodies monotherapy is scarce. We aimed to assess the risk of HBVr in patients with resolved HBV infection treated with rituximab or ocrelizumab in monotherapy for multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) without antiviral prophylaxis. [...]
D. Steinkopff-Verlag, 2023 - 10.1007/s00415-023-11973-y
Journal of Neurology, Vol. 271 (2024) p. 134-140
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4.
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12 p, 2.6 MB |
Traffic Lights Intervention Reduces Therapeutic Inertia : A Randomized Controlled Trial in Multiple Sclerosis Care
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Saposnik, Gustavo (St. Michael's Hospital, Toronto) ;
Mamdani, Muhammad (Li Ka Shing Centre for Healthcare Analytics Research and Training (LKS-CHART)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Terzaghi, Maria (St. Michael's Hospital, Toronto) ;
Silva, Berenice (Institute of Neuroscience Buenos Aires (INEBA)) ;
Saladino, Maria Laura (Institute of Neuroscience Buenos Aires (INEBA)) ;
Tobler, Philippe N. (University of Zurich) ;
Caceres, Fernando (Institute of Neuroscience Buenos Aires (INEBA)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Therapeutic inertia (TI) is a common phenomenon among physicians who care for patients with chronic conditions. We evaluated the efficacy of the traffic light system (TLS) educational intervention to reduce TI among neurologists with MS expertise. [...]
2019 - 10.1177/2381468319855642
MDM Policy and Practice, Vol. 4 Núm. 1 (2019) , p. 1-12
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5.
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5 p, 336.0 KB |
Does attendance at the ECTRIMS congress impact on therapeutic decisions in multiple sclerosis care?
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Saposnik, Gustavo (University of Zurich) ;
Maurino, Jorge (University of Buenos Aires) ;
Sempere, Angel P. (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Terzaghi, Maria A. (St. Michael's Hospital, Toronto) ;
Amato, Maria Pia (University of Florence) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Conferences traditionally play an important role in the ongoing medical education of healthcare professionals. We assessed the influence of attending the ECTRIMS congress on therapeutic decision-making in multiple sclerosis (MS) care. [...]
2019 - 10.1177/2055217319835226
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 1 (1-3 2019) , p. 205521731983522
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6.
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10 p, 1.1 MB |
The Multiple Sclerosis Care Unit
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Sørensen, Per S (Copenhagen University Hospital) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Thalheim, Christoph (European Multiple Sclerosis Platform, Brussels) ;
Zaratin, Paola (Multiple Sclerosis International Federation (MSIF)) ;
Comi, Giancarlo (San Raffaele Hospital, Milan) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Treatment of multiple sclerosis (MS) has become increasingly multifaceted and comprises not only a variety of disease-modifying drugs with different mechanism of action but also a wide range of symptomatic therapies. [...]
2019 - 10.1177/1352458518807082
Multiple sclerosis, Vol. 25 Núm. 5 (april 2019) , p. 627-636
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7.
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11 p, 1.0 MB |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study
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Balk, Lisanne J. (Vrije Universiteit Amsterdam) ;
Coric, Danko (Vrije Universiteit Amsterdam) ;
Knier, Benjamin (Technische Universität München) ;
Zimmermann, Hanna G. (Charité - Universitätsmedizin Berlin) ;
Behbehani, Raed (Ibn Sina Hospital, Kuwait) ;
Alroughani, Raed (Amiri Hospital, Kuwait) ;
Martinez-Lapiscina, Elena H. (Hospital Clínic i Provincial de Barcelona) ;
Brandt, Alexander U. (Charité - Universitätsmedizin Berlin) ;
Sánchez-Dalmau, Bernardo (Hospital Clínic i Provincial de Barcelona) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Albrecht, Philipp (Heinrich Heine University) ;
Koska, Valeria (Heinrich Heine University) ;
Havla, Joachim (Ludwig-Maximilians Universitaet Muenchen) ;
Pisa, Marco (Vita-Salute San Raffaele University) ;
Nolan, Rachel C. (New York University School of Medicine) ;
Leocani, Letizia (Vita-Salute San Raffaele University) ;
Paul, Friedemann (Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin) ;
Aktas, Orhan (Heinrich Heine University) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Balcer, Laura J. (New York University School of Medicine) ;
Villoslada, Pablo (Hospital Clínic i Provincial de Barcelona) ;
Outteryck, Olivier (Université Lille) ;
Korn, Thomas (Munich Cluster for Systems Neurology (SyNergy)) ;
Petzold, Axel (Moorfields Eye Hospital & The National Hospital for Neurology and Neurosurgery) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. [...]
2019 - 10.1177/2055217319871582
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 3 (2019)
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8.
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9 p, 570.9 KB |
Pregnancy Outcomes During the Clinical Development Program of Cladribine in Multiple Sclerosis : An Integrated Analysis of Safety
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Giovannoni, Gavin (Queen Mary University of London) ;
Galazka, Andrew (Merck. Aubonne. Switzerland. a division of Merck KGaA) ;
Schick, Regina (Merck KGaA) ;
Leist, Thomas (Jefferson University) ;
Comi, Giancarlo (Università Vita-Salute San Raffaele. Ospedale San Raffaele) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Damian, Doris (EMD Serono Research and Development Institute. Inc) ;
Dangond, Fernando (EMD Serono Research and Development Institute. Inc) ;
Cook, Stuart (The State University of New Jersey) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: Although use of contraception was pre-specified during cladribine clinical trials for multiple sclerosis, some pregnancies did occur. Objective: This analysis reports on pregnancy outcomes in the cladribine clinical development program. [...]
2020 - 10.1007/s40264-020-00948-x
Drug Safety, Vol. 43 Núm. 7 (july 2020) , p. 635-643
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9.
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14 p, 1.0 MB |
Long-term safety and efficacy of daclizumab beta in relapsing-remitting multiple sclerosis : 6-year results from the SELECTED open-label extension study
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Gold, Ralf (Ruhr-University Bochum) ;
Radue, Ernst-Wilhem (University Hospital Basel (Basilea, Suïssa)) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Selmaj, Krzysztof. (University of Warmia and Mazury) ;
Havrdova, Eva Kubala (Charles University) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Stefoski, Dusan (Rush University Medical Center) ;
Sprenger, Till (DKD Helios Klinik Wiesbaden) ;
Robinson, Randy R. (AbbVie Inc.) ;
Fam, Sami (Biogen) ;
Smith, Jonathan (Biogen) ;
Chalkias, Spyros (Biogen) ;
Giannattasio, Giorgio (Biogen) ;
Lima, Gabriel (Biogen) ;
Castro-Borrero, Wanda (Biogen) ;
Universitat Autònoma de Barcelona
Objective: SELECTED, an open-label extension study, evaluated daclizumab beta treatment for up to 6 years in participants with relapsing multiple sclerosis who completed the randomized SELECT/SELECTION studies. [...]
2020 - 10.1007/s00415-020-09835-y
Journal of Neurology, Vol. 267 Núm. 10 (january 2020) , p. 2851-2864
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10.
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11 p, 473.7 KB |
Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting : PROTEC
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Berger, Thomas (Universitätsklinik für Neurologie) ;
Brochet, B. (Groupe Hospitalier Pellegrin Hôpital Pellegrin) ;
Brambilla, L. (IRCCS Foundation Neurological Institute Carlo Besta) ;
Giacomini, P.S. (Montreal Neurological Institute Hospital) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Vasco Salgado, A (Hospital Professor Doutor Fernando Fonseca) ;
Su, R (Biogen, USA) ;
Bretagne, A (Biogen International GmbH) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease. Objective: The aim is to evaluate the effectiveness of delayed-release dimethyl fumarate (DMF) on disease activity and PROs in patients with RRMS in the clinic. [...]
2019 - 10.1177/2055217319887191
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 4 (2019)
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