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12 p, 557.9 KB Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores / Funicello, Marcella (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Novelli, Michela (University of Pisa. Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology) ; Ragni, Maurizio (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Vottari, Teresa (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Cocuzza, Cesare (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; López Soriano, Joaquin (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Chiellini, Chiara (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Boschi, Federico (University of Verona (Verona, Itàlia). Department of Morphological-Biomedical Sciences) ; Marzola, Pasquina (University of Verona (Verona, Itàlia). Department of Morphological-Biomedical Sciences) ; Masiello, Pellegrino (University of Pisa. Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology) ; Saftig, Paul (Christian-Albrechts University (Kiel, Alemanya). Biochemical Institute) ; Santini, Ferruccio (Christian-Albrechts University (Kiel, Alemanya). Biochemical Institute) ; St-Jacques, René (Merck Frosst Centre for Therapeutic Research (Kirkland, Canadà)) ; Desmarais, Sylvie (Merck Frosst Centre for Therapeutic Research (Kirkland, Canadà)) ; Morin, Nicolas (Merck Frosst Centre for Therapeutic Research (Kirkland, Canadà)) ; Mancini, Joseph (Merck Frosst Centre for Therapeutic Research (Kirkland, Canadà)) ; Percival, M. David (Merck Frosst Centre for Therapeutic Research (Kirkland, Canadà)) ; Pinchera, Aldo (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism) ; Maffei, Margherita (University Hospital of Pisa (Pisa, Itàlia). Department of Endocrinology and Metabolism)
Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white adipose tissue (WAT) of obese individuals. [...]
2007 - 10.1371/journal.pone.0000683
PLoS one, Vol. 2, Issue 8 (August 2007) , p. e683  

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2 Novelli, Mario
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