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11.
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9 p, 1.7 MB |
Switching From a Protease Inhibitor-based Regimen to a Dolutegravir-based Regimen : A Randomized Clinical Trial to Determine the Effect on Peripheral Blood and Ileum Biopsies From Antiretroviral Therapy-suppressed Human Immunodeficiency Virus-infected Individuals
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Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez, Montse (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rutsaert, Sofie (Universitair Ziekenhuis Gent) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron) ;
De Clercq, Laura (Universitair Ziekenhuis Gent) ;
Ribas, Bibiana Planas (Hospital Universitari Vall d'Hebron) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vandekerckhove, Linos (Universitair Ziekenhuis Gent) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Crespo Casal, Manuel (Instituto de Investigación Sanitaria Galicia Sur) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted protease inhibitor (PI/r)-based therapy to dolutegravir (DTG)-based therapy. [...]
2018 -  10.1093/cid/ciy1095
Clinical Infectious Diseases, Vol. 69 (december 2018) , p. 1320-1328
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12.
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25 p, 2.8 MB |
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages
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Bejarano, David Alejandro (Department of Infectious Diseases, Virology. University of Heidelberg. Heidelberg, Germany) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Börner, Kathleen (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Müller, Barbara (Department of Infectious Diseases, Virology, University of Heidelberg. Heidelberg, Germany) ;
Kräusslich, Hans-Georg (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany)
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. [...]
2018 - 10.3390/v10110620
Viruses, Vol. 10 (november 2018)
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13.
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10 p, 2.1 MB |
Sensitive quantification of the HIV-1 reservoir in gut-associated lymphoid tissue
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Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Carrasco-Rozas, Ana (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Esteve, Maria (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Manyè, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Background. The implementation of successful strategies to achieve an HIV cure has become a priority in HIV research. However, the current location and size of HIV reservoirs is still unknown since there are limited tools to evaluate HIV latency in viral sanctuaries such as gut-associated lymphoid tissue (GALT). [...]
2017 - 10.1371/journal.pone.0175899
PloS one, Vol. 12 Núm. 4 (2017) , p. 1-10
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14.
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11 p, 1018.7 KB |
Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects
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Hancock, Gemma ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kopycinski, Jakub ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giannoulatou, Eleni (University of New South Wales) ;
Rose, Annie ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hayton, Emma-Jo ;
Crook, Alison ;
Morgan, Catharine ;
Angus, Brian ;
Chen, Fabian ;
Yang, Hongbing ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš ;
Dorrell, Lucy ;
Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)
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15.
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15 p, 4.1 MB |
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART
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Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ;
Pou, Christian (Karolinska Institutet (Estocolm, Suècia). Department of Cell and Molecular Biology) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ;
Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ;
Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)
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16.
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10 p, 473.8 KB |
Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy
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Martínez-Bonet, Marta (Hospital General Universitario Gregorio Marañón) ;
Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fortuny Guasch, Claudia (Hospital Sant Joan de Déu (Manresa)) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mellado, Maria José (Hospital Universitario infantil La Paz (Madrid)) ;
Rojo, Pablo (Hospital Universitario 12 de Octubre (Madrid)) ;
Noguera-Julian, Antoni (Hospital Sant Joan de Déu (Manresa)) ;
Muñoz-Fernández, Ma Angeles (Hospital General Universitario Gregorio Marañón) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Initiation of combined antiretroviral therapy within the first 12 weeks of life in vertically human immunodeficiency virus type 1-infected children favors the establishment of low-level proviral reservoirs. [...]
2015 - 10.1093/cid/civ456
Clinical Infectious Diseases, Vol. 61 (june 2015) , p. 1169-1178
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17.
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16 p, 1.9 MB |
The infectious synapse formed between mature dendritic cells and CD4 + T cells is independent of the presence of the HIV-1 envelope glycoprotein
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Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puigdomènech, Isabel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Since cell-mediated infection of human immunodeficiency virus type 1 (HIV-1) is more efficient than cell-free infection, cell-to-cell propagation plays a crucial role in the pathogenesis of HIV-1 infection. [...]
2013 - 10.1186/1742-4690-10-42
Retrovirology, Vol. 10 (april 2013) , p. 42
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18.
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11 p, 527.4 KB |
Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART
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Buzón, Maria José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codoñer, Francisco M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Frost, Simon D. W. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Stevenson, Mario (University of Miami Miller School of Medicine, Miami, Florida, United States of America) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
In order to design strategies for eradication of HIV-1 from infected individuals, detailed insight into the HIV-1 reservoirs that persist in patients on suppressive antiretroviral therapy (ART) is required. [...]
2011 - 10.1371/journal.ppat.1002314
PLOS pathogens, Vol. 7 (october 2011)
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19.
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17 p, 1.3 MB |
Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy
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Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ;
Garriga, César (Centro Nacional de Epidemiología (Espanya)) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Anta, Lourdes (Hospital Carlos III (Madrid)) ;
Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ;
Pérez Elías, M. Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Mendoza, Carmen de (Hospital Carlos III (Madrid)) ;
Martínez, Miguel A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Menéndez-Arias, Luis (Centro de Biología Molecular Severo Ochoa) ;
Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - 10.1186/1742-4690-9-68
Retrovirology, Vol. 9, N. 68 (13 August 2012) , p. 1-17
2 documents
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20.
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9 p, 5.6 MB |
HIV and mature dendritic cells : Trojan exosomes riding the Trojan horse?
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Naranjo-Gómez, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. [...]
2010 - 10.1371/journal.ppat.1000740
PLOS pathogens, Vol. 6, Issue 3 (March 2010) , p. e1000740
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